DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and OPCML

DIOPT Version :9

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:NP_001306032.1 Gene:OPCML / 4978 HGNCID:8143 Length:354 Species:Homo sapiens


Alignment Length:308 Identity:81/308 - (26%)
Similarity:125/308 - (40%) Gaps:55/308 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   257 FMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARILH----------------- 304
            |.|...:..:..|::||..|:: .|...:|.|        ::|:.||:                 
Human    38 FPKAMDNVTVRQGESATLRCTI-DDRVTRVAW--------LNRSTILYAGNDKWSIDPRVIILVN 93

  Fly   305 --DEKSLEISNITPTDEGTYVCEAHNNVGQISARASLIVHAPPNFTKRPSNKKVGLNGVVQLPCM 367
              .:.|:.|.|:...|||.|.|....:....::|..|||..||......|:..|.....|.|.|:
Human    94 TPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCL 158

  Fly   368 ASGNPPPSVFWTKEGVSTLMFPNSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRV 432
            |.|.|.|:|.|....|        ..|:..|:.|..|:|:|::::..|.|.|||.:.|.:..|| 
Human   159 AIGRPEPTVTWRHLSV--------KEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVR- 214

  Fly   433 FLQVSSLDERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFH---------DGHAVQAG 488
              :|......||.|.:  ..|..:..|....|.|.|:..|....:||.         ||..::..
Human   215 --KVKITVNYPPYISK--AKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENK 275

  Fly   489 NRYSIIQGSSLRVDDLQLSDSGTYTCTASGERGETSWAATLTVEKPGS 536
            .|.     |:|...::...|.|.|||.|:.:.|.|:.:.||....|.|
Human   276 GRM-----STLTFFNVSEKDYGNYTCVATNKLGNTNASITLYEISPSS 318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:299845
I-set 56..150 CDD:254352
I-set 157..251 CDD:254352
Ig2_Robo 159..251 CDD:143201
I-set 255..341 CDD:254352 22/102 (22%)
Ig3_Robo 272..341 CDD:143202 19/87 (22%)
IG_like 351..436 CDD:214653 26/84 (31%)
Ig 362..444 CDD:299845 25/81 (31%)
I-set 445..531 CDD:254352 24/94 (26%)
IGc2 459..521 CDD:197706 18/70 (26%)
FN3 549..637 CDD:238020
FN3 673..762 CDD:238020
fn3 770..855 CDD:278470
OPCMLNP_001306032.1 Ig 44..132 CDD:416386 20/96 (21%)
Ig strand A' 44..49 CDD:409353 0/4 (0%)
Ig strand B 51..59 CDD:409353 3/7 (43%)
CDR1 59..63 CDD:409353 1/4 (25%)
FR2 64..70 CDD:409353 2/13 (15%)
Ig strand C 64..70 CDD:409353 2/13 (15%)
CDR2 71..83 CDD:409353 3/11 (27%)
Ig strand C' 72..76 CDD:409353 1/3 (33%)
Ig strand C' 80..83 CDD:409353 0/2 (0%)
FR3 84..118 CDD:409353 8/33 (24%)
Ig strand D 87..94 CDD:409353 0/6 (0%)
Ig strand E 97..103 CDD:409353 1/5 (20%)
Ig strand F 110..118 CDD:409353 4/7 (57%)
CDR3 119..123 CDD:409353 0/3 (0%)
Ig strand G 123..132 CDD:409353 2/8 (25%)
FR4 125..132 CDD:409353 2/6 (33%)
Ig_3 135..206 CDD:404760 25/78 (32%)
Ig strand A 135..138 CDD:409353 2/2 (100%)
Ig strand A' 144..148 CDD:409353 0/3 (0%)
Ig strand B 151..160 CDD:409353 3/8 (38%)
Ig strand C 165..170 CDD:409353 2/4 (50%)
Ig strand C' 171..174 CDD:409353 0/2 (0%)
Ig strand F 198..206 CDD:409353 5/7 (71%)
Ig 224..312 CDD:416386 24/94 (26%)
putative Ig strand A 224..230 CDD:409353 2/7 (29%)
Ig strand B 240..244 CDD:409353 1/3 (33%)
Ig strand C 253..257 CDD:409353 0/3 (0%)
Ig strand E 279..283 CDD:409353 2/3 (67%)
Ig strand F 293..298 CDD:409353 3/4 (75%)
Ig strand G 306..309 CDD:409353 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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