DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and Cadm2

DIOPT Version :9

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:XP_038944379.1 Gene:Cadm2 / 360687 RGDID:1305678 Length:444 Species:Rattus norvegicus


Alignment Length:460 Identity:107/460 - (23%)
Similarity:167/460 - (36%) Gaps:98/460 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 GQTATFHCSVGGDPPPKVLW------------KKEEGNIPVSRARILHDEKSLEISNITPTDEGT 321
            |.||...|.|..:....:.|            ||...:..:...|....|.|:.:|:::.:|||.
  Rat    46 GGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQ 110

  Fly   322 YVCEAHNNVGQISARASLIVHAPPNFTKRPS----NKKVGLNGVVQLPCMASGNPPPS-VFW--- 378
            |.|.......:.| :|.|.|...|   ::|.    :..|....::||.|..||:.|.: :.|   
  Rat   111 YTCSLFTMPVKTS-KAYLTVLGVP---EKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKN 171

  Fly   379 TKEGVSTLMFPNSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQVSSLDERP 443
            .||.............|:......||.....|.:|....:|.......::|.:|.:||  |:...
  Rat   172 DKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQV--LEIHY 234

  Fly   444 PPIIQIGPANQTLPKGSVATLPCRATGNPSPR-IKWFHDGHAVQAGNRYSIIQGSSLRVDDLQLS 507
            .|.::|.|:.....:|...||.|.:.|.|.|. :.|..||..:...:| .::.|..|.:..|..:
  Rat   235 TPSVKIIPSTPFPQEGQALTLTCESKGKPLPEPVLWTKDGAELPDPDR-MVVSGRELNILFLNKT 298

  Fly   508 DSGTYTCTASGERGETSWAATLTVEKPGSTSLHRAADPSTYPAPPGTPKVLNVS-RTSISLRWAK 571
            |:|||.|.|:...|::|....|.|....:|.|.....||...||..|...:..| .||.|   :.
  Rat   299 DNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTAPVTTTVAITTSPSTSAS---SS 360

  Fly   572 SQEKPGAVGPIIGYTVEYFSPDLQTGWIVAAQRVGDTQVTISGLTPGTSYV----------FLVR 626
            |:..|.::                      |.:.|.....|.|:.....:|          :|.|
  Rat   361 SRRDPNSL----------------------AGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLAR 403

  Fly   627 AENTQGISVPSGLSNTIKTIEADFDAASANDLSAARTLLTGKSVELIDASAINASAVRLEWMLHV 691
            .:.|.       |:|..|..|   ||..|                  |.:.|||...:      |
  Rat   404 HKGTY-------LTNEAKGAE---DAPDA------------------DTAIINAEGSQ------V 434

  Fly   692 SADEK 696
            :|:||
  Rat   435 NAEEK 439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:299845
I-set 56..150 CDD:254352
I-set 157..251 CDD:254352
Ig2_Robo 159..251 CDD:143201
I-set 255..341 CDD:254352 20/83 (24%)
Ig3_Robo 272..341 CDD:143202 18/80 (23%)
IG_like 351..436 CDD:214653 19/92 (21%)
Ig 362..444 CDD:299845 20/85 (24%)
I-set 445..531 CDD:254352 26/86 (30%)
IGc2 459..521 CDD:197706 20/62 (32%)
FN3 549..637 CDD:238020 17/98 (17%)
FN3 673..762 CDD:238020 8/24 (33%)
fn3 770..855 CDD:278470
Cadm2XP_038944379.1 IgV_1_Necl-3 35..130 CDD:409498 20/84 (24%)
Ig strand B 49..53 CDD:409498 1/3 (33%)
Ig strand C 62..66 CDD:409498 0/3 (0%)
Ig strand E 96..100 CDD:409498 1/3 (33%)
Ig strand F 110..115 CDD:409498 2/4 (50%)
Ig strand G 122..125 CDD:409498 1/3 (33%)
IgI_2_Necl-3 129..232 CDD:409467 24/107 (22%)
Ig strand B 151..155 CDD:409467 2/3 (67%)
Ig strand C 165..169 CDD:409467 0/3 (0%)
Ig strand E 195..199 CDD:409467 2/3 (67%)
Ig strand F 209..214 CDD:409467 1/4 (25%)
Ig strand G 225..228 CDD:409467 1/2 (50%)
IGc2 249..312 CDD:197706 20/63 (32%)
Ig strand B 251..260 CDD:409353 3/8 (38%)
Ig strand C 266..272 CDD:409353 1/5 (20%)
Ig strand C' 275..278 CDD:409353 0/2 (0%)
Ig strand D 281..286 CDD:409353 1/5 (20%)
Ig strand E 287..294 CDD:409353 2/6 (33%)
Ig strand F 301..309 CDD:409353 5/7 (71%)
Ig strand G 312..322 CDD:409353 3/9 (33%)
4.1m 397..415 CDD:128590 5/24 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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