DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment robo1 and Nectin2

DIOPT Version :9

Sequence 1:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster
Sequence 2:	NP_001012064.1	Gene:	Nectin2 / 308417	RGDID:	1309505	Length:	530	Species:	Rattus norvegicus

Alignment Length:	678	Identity:	151/678 - (22%)
Similarity:	210/678 - (30%)	Gaps:	247/678 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 PPKGIPEPTLIWIKDGVPLDDLKAMSFGASS-RVRIVD------GG------NLLISNVEPIDEG 229
            ||..: .|||..:    ||..|.....||.. |||::.      ||      :||....|.:.:.
  Rat     8 PPSRL-SPTLPLL----PLLLLLLQETGAQDVRVRVLPEVRGRLGGTVELPCHLLPPTTERVSQV 67

  Fly   230 NYKCIAQNLVGTRESSYAKLIVQVKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWK----- 289
            .:    |.|.||                            ..|.||.|.|.|.|.....|
  Rat    68 TW----QRLDGT----------------------------VVAAFHPSFGVDFPNSQFNKDRLSF 100

  Fly   290 ---KEEGNIPVSRARILHDEKSLEISNITPTDEGTYVCEAHNNVGQISARASLIVHAPPNFTKR- 350
               |:|.|..:..|       :|....:...|||.|.||.          |:.     ||.|:|
  Rat   101 VRAKQEANADLRDA-------TLAFRGLRVEDEGNYTCEF----------ATF-----PNGTRRG 143

  Fly   351 ---------PSNK------KVGLNGVVQLPCMASGNPPPS-VFWTKEGVSTLMFPNSSHGRQHVA 399
                     |.|.      .:|...|....|:::|..||: :.|    :|:|      .|.....
  Rat   144 VTWLRVIAQPENHAEAQEVTIGPQSVAVARCISTGGRPPARITW----ISSL------GGEARDI 198

  Fly   400 ADGTLQITDVRQEDEGYYVCSAFSVV-----DSSTVRVFLQVSSLDE----------RPPPIIQI 449
            .:..||...|.       |.|.:|:|     |...|...::..||:|          |.||.:.|
  Rat   199 QEPGLQAGTVT-------VISRYSMVPVGRADGVKVTCRVEHESLEEPELLPVILSVRYPPEVSI 256

  Fly   450 GPANQTLPKG-SVATLPCRATGNPSPR-IKWFHDGHAVQAGNRYSIIQGSSLRVDDLQLSDSGTY 512
            ...:.....| |.|||.|....||.|. ..|........|.   ::.|||.|.|..:....:.|:
  Rat   257 SGYDDNWYLGRSEATLTCEVRSNPEPTGYDWSTTSGVFPAS---AVAQGSQLLVHSVDRMVNTTF 318

  Fly   513 TCTASGERGETSWAATLTVEKPGSTSLHRAADPSTYPAPPGTPKVLNVSRTSISLRWAKSQEKPG 577
            .|||:...|.......:.|.:          .|||..|                          |
  Rat   319 ICTATNAVGTGRAEQVILVRE----------SPSTAGA--------------------------G 347

  Fly   578 AVGPIIGYTVEYF--SPDLQTGWIVAAQ-------RVGDTQVTISG---LTPGTSYVFLVRAENT 630
            |.|.|||..:...  :....||.::..|       :..|.:..:.|   ..|.|....|...|
  Rat   348 ATGGIIGGIIAAIIATAVAGTGILICRQQRKEQRLQAADEEEELEGPPSYKPPTPKAKLEEPE-- 410

  Fly   631 QGISVPSGL-------SNTIKTIEADFDA-ASANDLSAAR-----TLLTGKSVELIDASAINASA 682
                :||.|       .:.:||  ..||| .|..|....|     ||.......|:.|:.:..|
  Rat   411 ----MPSQLFTLGPSEHSPVKT--PYFDAGVSCADQEMPRYHELPTLEERSGPLLLGATGLGPS- 468

  Fly   683 VRLEWMLHVSADEKYVEGLRIHYKDASVPSAQYHSITVMDASAESFVVGNLKKYTKYEFFLTPFF 747
                  |.|......|||:.:..:|..           .|...|.|    |.|       :.|.:
  Rat   469 ------LLVPPGPNVVEGVSLGLEDEE-----------EDEEEEDF----LDK-------INPIY 505

  Fly   748 ETIEGQPSNSKTALTYEDVPSAPPDNIQ 775
            :           ||:|   || |.|:.|
  Rat   506 D-----------ALSY---PS-PSDSYQ 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo1	NP_476899.1	Ig	56..151	CDD:299845
		I-set	56..150	CDD:254352
		I-set	157..251	CDD:254352	22/85 (26%)
		Ig2_Robo	159..251	CDD:143201	22/85 (26%)
		I-set	255..341	CDD:254352	20/93 (22%)
		Ig3_Robo	272..341	CDD:143202	20/76 (26%)
		IG_like	351..436	CDD:214653	21/96 (22%)
		Ig	362..444	CDD:299845	21/97 (22%)
		I-set	445..531	CDD:254352	23/87 (26%)
		IGc2	459..521	CDD:197706	20/63 (32%)
		FN3	549..637	CDD:238020	16/99 (16%)
		FN3	673..762	CDD:238020	15/88 (17%)
		fn3	770..855	CDD:278470	3/6 (50%)
Nectin2	NP_001012064.1	IG_like	40..149	CDD:214653	33/162 (20%)
		Ig1_PVR_like	48..150	CDD:143195	32/155 (21%)
		Ig	153..248	CDD:299845	24/111 (22%)
		Ig	269..327	CDD:299845	18/60 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000