DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and cdon

DIOPT Version :10

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:NP_001075097.1 Gene:cdon / 280652 ZFINID:ZDB-GENE-021115-4 Length:1125 Species:Danio rerio


Alignment Length:1136 Identity:239/1136 - (21%)
Similarity:406/1136 - (35%) Gaps:290/1136 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 PTDLVVKKNEPATLNCKVEGKPEPTIEWFKDGEPVSTNEKKSHR--VQFKDGALFFYRTMQGKKE 124
            |...::|:.....|:|... .....|.|...|:|:.    .||.  |:....:|    ::...:.
Zfish    35 PLSAILKQGSSVHLHCTTH-PATARISWLFQGQPLD----PSHHSGVELSQDSL----SLSNLQP 90

  Fly   125 QDGGEYWCVAKNRVGQAVSRHASLQIAVLRDDFRVEPKDTRVAKGETALLECGPPKGIPEPTL-- 187
            ...|.|.|.|::..|..:||||.:.||.:.:......:...|.||:||::||..|:..| |.|  
Zfish    91 ALTGSYQCSARSETGSIISRHARVTIADIEEFAETHRRSFTVNKGDTAVIECPLPRSNP-PALPR 154

  Fly   188 -----IWIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSY- 246
                 .|::.             ::....|:..|||.|.:|....:|.|||.|.|.: |||:.. 
Zfish   155 FRIRGKWLEQ-------------STDEYLILPSGNLQIVSVSSEHQGMYKCGAYNPL-TRETRVE 205

  Fly   247 ---AKLIVQ-------VKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSRAR 301
               .||:|:       |:..:...|:...:....:.|..|.|.|....||.|.|....:.:|..|
Zfish   206 AHGTKLLVKDSESSSPVRIVYPITPRSLTVDQSGSLTLECVVSGSLSSKVKWMKNGAELSLSSKR 270

  Fly   302 ILHDEKSLEISNITPTDEGTYVCEAHNNVGQ-ISARASLIVHAPPNFTKRPSNKKVGLNGVVQLP 365
            :| ...:|.:::|.|.|.|.|.|....:.|. :|...::.|.|..:..:..|::.......|:..
Zfish   271 ML-SHSNLVLNDIQPGDGGHYSCSVPTDRGAVVSVNYTVNVLAHVSILRGLSDQAAVAGSSVRFT 334

  Fly   366 CMASGNPPPSVFWTKEGVSTLMFPNSSHGRQHVAADGT-LQITDVRQEDEGYYVCSAFSVVDS-- 427
            |.|||||.|::.|.....     |.||..|..::  || |.|:....:|:|.|.|...:.:.|  
Zfish   335 CAASGNPTPNITWLLNAA-----PLSSSPRLKIS--GTSLLISSTTLQDQGIYQCMFDNGISSAQ 392

  Fly   428 STVRVFLQ-------VSSLDERPPPIIQ----------------------IGPANQTL-----PK 458
            ||.|:.:|       :|::..:..|.:.                      :||..:.:     |:
Zfish   393 STGRLSIQSEPQSSSISAVPVKTQPSVHPIQSDEGDELFLSMGEAALGETVGPPTERIGDRPTPE 457

  Fly   459 GSVATLPCRATGNPSP-RIKWFHDGHAVQAGNRYSI--------------------------IQG 496
            ..:...|.: |..|:. .::|       :||..:.|                          :.|
Zfish   458 APIIISPPQ-THKPNMYDLEW-------RAGRDWGIAIIAYFVKYRKVDDMGNVVGSWHTVRVPG 514

  Fly   497 SSLRVDDLQLSDSGTYTC-----TASGERGETSWAATLTVEKPGSTSLHRAADP----------- 545
            |...:...:|..|..|..     :|:|| |:.:.....|.::..|.:.:.:..|           
Zfish   515 SEKSLPLSELEPSSLYEVLMVARSAAGE-GQPAMLTFRTGKERASPNKNPSKAPIVSLPEKTPED 578

  Fly   546 ---STY---------PAPPGTPKVLNVSRTSISLRWAKSQEKPGAVG--PIIGYTVEYFSPDLQT 596
               :||         |..|..|.:...:.:|:.:.|.     |.|.|  ||..:.|||.......
Zfish   579 KTTNTYYGVVIHDRVPEAPDRPTISMATESSVYVTWI-----PRANGGSPITAFRVEYRKQGRNG 638

  Fly   597 GWIVAAQRVGDTQ--VTISGLTPGTSYVFLVRAENTQGISVPSGLSNTIKTIEADFDAASANDLS 659
            .||:||..:...:  |.:..|.||::|.|.|.|.|..|.|..|..|...:        .|.:...
Zfish   639 DWIIAADNISPLKLSVEVRNLEPGSTYRFRVIAMNNYGESPASATSRPYQ--------VSMSSSP 695

  Fly   660 AARTLLTGKSVELIDASAINASAVRLEWMLHVSADEKY-VEGLRIHYKDASVPSAQYHSITVMDA 723
            .:...:||..:...|  |::.:.:.|.|....|::... ::|..|:|:.....:...:...|::.
Zfish   696 VSNRPVTGPHISSTD--AVSDTQILLRWTYTPSSNNNTPIQGFYIYYRPTDSDNDSDYKKDVVEG 758

  Fly   724 SAESFVVGNLKKYTKYEFFLTPFFETIEGQPSNSKTALTYEDVPSAPPDNIQIGMYNQTAGWVRW 788
            .....::|.|:..|.|:..:..:.:..|.:.||.....|....|...|....|            
Zfish   759 FKFWHMIGELQPETSYDIKMQCYNDGGESEYSNVMICETKARQPPGVPSLRPI------------ 811

  Fly   789 TPP-------PSQHHNGNLYGYKIEVSAGNTMKVLANMTLNATTTSVLLNNLTTGAVY------- 839
            |||       ||| ..|.||     :..|..:.|:. :.|.......|..|....:::       
Zfish   812 TPPGFYPADTPSQ-PGGLLY-----LIVGCVLGVMV-LILLVFIVMCLWRNRQQNSMHKYDPPNY 869

  Fly   840 -------------------SVRLNSFTKAGDGPYSKPISLFMDPT-HHVHP-------------- 870
                               |..:|.....|.| ::.|:   |..| ||:|.              
Zfish   870 IYQSAEMNGHVLDYSALPGSSHVNGSVHTGCG-HTAPM---MPQTCHHLHHKLPNGLALLNGSGG 930

  Fly   871 --PRAHPSGTHDGRHEGQDLTY--------HNNGNI----PPGDI-----------NPTTHKKTT 910
              |..||. .||......::.|        ||.|.|    |..|.           |...:.||.
Zfish   931 LYPAGHPH-AHDTSLHQNNMEYEHPSPHHLHNGGGIYTALPQNDSSDCMSCQNFCNNNRCYTKTN 994

  Fly   911 DYLSGPWLMVLVCIV------LLVLVISAAISMVYFKRKHQMT----------KELGHLSVVSDN 959
            ...||..|.::..:.      |.::.::..:|..:.:...|:.          .|.|::..:|.|
Zfish   995 GTFSGGTLPLMHRVAARQPDGLEMMPLNPILSRCHGRDSPQLNGCQDRDSVQQAEEGNVPPLSHN 1059

  Fly   960 EITALNINSKESLWIDHHRGWRTADTDKDSG 990
            . ..|.:.:|.||  :..||.:....:...|
Zfish  1060 S-PCLPVETKSSL--EQQRGVQQVQHEDSEG 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:472250 21/90 (23%)
Ig strand B 73..77 CDD:409353 1/3 (33%)
Ig strand C 86..90 CDD:409353 1/3 (33%)
Ig strand E 111..115 CDD:409353 1/3 (33%)
Ig strand F 129..134 CDD:409353 2/4 (50%)
Ig strand G 143..146 CDD:409353 2/2 (100%)
IgI_2_Robo 158..251 CDD:409389 29/103 (28%)
Ig strand A 158..161 CDD:409389 0/2 (0%)
Ig strand A' 163..167 CDD:409389 0/3 (0%)
Ig strand B 171..178 CDD:409389 4/6 (67%)
Ig strand C 186..191 CDD:409389 2/11 (18%)
Ig strand C' 193..196 CDD:409389 0/2 (0%)
Ig strand D 209..213 CDD:409389 0/3 (0%)
Ig strand E 216..222 CDD:409389 4/5 (80%)
Ig strand F 229..237 CDD:409389 5/7 (71%)
Ig strand G 240..251 CDD:409389 5/14 (36%)
IgI_3_Robo 258..341 CDD:409390 21/83 (25%)
Ig strand A 258..261 CDD:409390 0/2 (0%)
Ig strand A' 263..267 CDD:409390 0/3 (0%)
Ig strand B 270..279 CDD:409390 2/8 (25%)
Ig strand C 285..290 CDD:409390 3/4 (75%)
Ig strand C' 293..296 CDD:409390 0/2 (0%)
Ig strand D 299..304 CDD:409390 1/4 (25%)
Ig strand E 305..313 CDD:409390 1/7 (14%)
Ig strand F 320..328 CDD:409390 3/7 (43%)
Ig strand G 331..341 CDD:409390 2/10 (20%)
Ig 346..437 CDD:472250 27/100 (27%)
Ig strand B 362..366 CDD:409353 1/3 (33%)
Ig strand C 375..379 CDD:409353 0/3 (0%)
Ig strand E 402..406 CDD:409353 3/4 (75%)
Ig strand F 416..421 CDD:409353 2/4 (50%)
Ig strand G 429..432 CDD:409353 1/2 (50%)
Ig 446..531 CDD:472250 19/143 (13%)
Ig strand B 462..466 CDD:409544 0/3 (0%)
Ig strand C 475..479 CDD:409544 0/3 (0%)
Ig strand E 497..501 CDD:409544 1/3 (33%)
FN3 507..>916 CDD:442628 104/514 (20%)
Ig strand F 511..516 CDD:409544 1/9 (11%)
Ig strand G 524..527 CDD:409544 0/2 (0%)
FN3 549..637 CDD:238020 28/91 (31%)
fn3 770..855 CDD:394996 20/117 (17%)
cdonNP_001075097.1 IG_like 131..213 CDD:214653 29/96 (30%)
Ig strand B 138..142 CDD:409353 1/3 (33%)
Ig strand C 152..156 CDD:409353 1/3 (33%)
Ig strand E 175..179 CDD:409353 3/3 (100%)
Ig strand F 189..194 CDD:409353 3/4 (75%)
IG_like 230..310 CDD:214653 21/80 (26%)
Ig strand B 241..245 CDD:409353 1/3 (33%)
Ig strand C 254..258 CDD:409353 2/3 (67%)
Ig strand E 276..279 CDD:409353 1/2 (50%)
Ig strand F 289..294 CDD:409353 2/4 (50%)
Ig strand G 302..306 CDD:409353 1/3 (33%)
I-set 315..399 CDD:400151 26/90 (29%)
Ig strand B 331..335 CDD:409353 1/3 (33%)
Ig strand C 344..348 CDD:409353 0/3 (0%)
Ig strand E 365..369 CDD:409353 2/3 (67%)
Ig strand F 379..384 CDD:409353 2/4 (50%)
Ig strand G 392..395 CDD:409353 1/2 (50%)
fn3 475..545 CDD:394996 13/77 (17%)
FN3 <584..>815 CDD:442628 56/257 (22%)
FN3 594..685 CDD:238020 29/95 (31%)
Ig 28..116 CDD:472250 21/89 (24%)
Ig strand B 46..50 CDD:409353 1/3 (33%)
Ig strand C 58..62 CDD:409353 1/3 (33%)
Ig strand E 81..85 CDD:409353 1/7 (14%)
Ig strand F 96..100 CDD:409353 2/3 (67%)
Ig strand G 109..112 CDD:409353 2/2 (100%)

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