back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo1 and Ptprs

DIOPT Version :9

Sequence 1:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster
Sequence 2:	XP_038938979.1	Gene:	Ptprs / 25529	RGDID:	3452	Length:	1926	Species:	Rattus norvegicus

Alignment Length:	1250	Identity:	277/1250 - (22%)
Similarity:	414/1250 - (33%)	Gaps:	374/1250 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 IVQVKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARIL-HDEKSLEISN 313
            :.:..|.|::|||||:.:.|..|:|.|...|||.|:|.|.|:...:...|...: .||.|..:..
  Rat    28 LAEEPPRFIREPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIDFDESSGAVLR 92

  Fly   314 I----TPTDEGTYVCEAHNNVGQISARASLIV----HAPPNFTK---RPSNKKVGLNGVVQLPCM 367
            |    ||.||..|.|.|.|:||:|:..|.|.|    ..||.|..   .|..|.|.......:.|.
  Rat    93 IQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPPGFPNIDMGPQLKVVERTRTATMLCA 157

  Fly   368 ASGNPPPSVFWTKEGVSTLMFPNSSHGR------QHVAADGTLQITDVRQEDEGYYVCSAFSVVD 426
            |||||.|.:.|.|:.:.  :.|::|:||      :.....|.|||....:.|:|.|.|.|   .:
  Rat   158 ASGNPDPEITWFKDFLP--VDPSASNGRIKQLRSESTPIRGALQIESSEETDQGKYECVA---TN 217

  Fly   427 SSTVR----VFLQVSSLDE--RPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHDGHAV 485
            |:.||    ..|.|..|.|  |..|...|.|.:..:..|....:.|.|.|:|.|.:||
  Rat   218 SAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW------- 275

  Fly   486 QAGNRYSIIQGS-SLRVDD--------LQLS---DSGTYTCTASGERGETSWAATLTVEKPGSTS 538
                    :||: .|..:|        |:|:   ||..|||.|....|.....|.:||:
  Rat   276 --------MQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVK------ 326

  Fly   539 LHRAADPSTYPAPPGTPKVLNVSRTSISLRWAKSQEKPGAVGPIIGYTVEYFSPDLQTGWIVAAQ 603
                    :.|..||||.|...:.|||::.|     ..|...|:..|.:||.|.. |.|.....:
  Rat   327 --------SLPKAPGTPVVTENTATSITVTW-----DSGNPDPVSYYVIEYKSKS-QDGPYQIKE 377

  Fly   604 RVGDTQVTISGLTPGTSYVFLVRAENTQGISVPSGLSNTIKTIEADFDAASANDLSAARTLLTGK 668
            .:..|:.:|.||:|.:.|...|.|.|:.|...|   |.::.|...:...|||
  Rat   378 DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPP---SESVVTRTGEQAPASA------------- 426

  Fly   669 SVELIDASAINASAVRLEWMLHVSADEKYVEGLRIHY---KDASVPSAQYHSI------------ 718
             ...:.|..::|:.:.::|...|..: ..:.|.|::|   .:..|.:.|.|::
  Rat   427 -PRNVQARMLSATTMIVQWEEPVEPN-GLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLL 489

  Fly   719 -----TV-----------------------------MDASAE----------------------- 726
                 ||                             |:..||
  Rat   490 EDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAKSETSIGLSWSAPRQESVIKYE 554

  Fly   727 --------------------SFVVGNLKKYTKYEFFL---TPFFETIEGQPSNSKTAL----TYE 764
                                :|||.:||..|:|.|.|   :|       |...:.||:    |.:
  Rat   555 LLFREGDRGREVGRTFDPTTAFVVEDLKPNTEYAFRLAARSP-------QGLGAFTAVVRQRTLQ 612

  Fly   765 DVPSAPPDNIQIGMYNQTAGWVRWTPPPSQHHNGNLYGYKIEV----SAGNTMKVLANMTLNATT 825
            ..|||||.:::......||..|.|.|||.:.|||.|.||.:..    |.....|.:.|  :..||
  Rat   613 AKPSAPPQDVKCTSLRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPDPKEVNN--IPPTT 675

  Fly   826 TSVLLNNLTTGAVYSVRLNSFTKAGDGPYSKPISLFMDPTHHVHPPRAHPSGTHDGRHEGQDLTY 890
            |.:||..|.....|.|...::|:.|.||.|.|:.:..|......|||
  Rat   676 TQILLEALEKWTEYRVTAVAYTEVGPGPESSPVVVRTDEDVPSAPPR------------------ 722

  Fly   891 HNNGNIPPGDINPTTHKKTTDYLSGPWLMVLVCIVLLVLVISAAISMVYFKRKHQMTKELGHLSV 955

  Rat   723 ----------------------------------------------------------------- 722

  Fly   956 VSDNEITALNINSKESLWIDHHRGWRTADTDKDSGLSESKLLSHVNSSQSNYNNSDGGTDYAEVD 1020
              ..|..|||..:...|       ||:....:..|        .:...|.:|...:|........
  Rat   723 --KVEAEALNATAIRVL-------WRSPTPGRQHG--------QIRGYQVHYVRMEGAEARGPPR 770

  Fly  1021 TRNLTTFYNCRKSPDNPTPYATTMIIGTSSSETC-TKTTSISADKDSGTHSPYSDAFAGQVPAVP 1084
            .::: ...:.:...|:...|  .|:|.....||. :.|.:....|..|..|.         |.|.
  Rat   771 IKDI-MLADAQWEMDDTAEY--EMVITNLQPETAYSITVAAYTMKGDGARSK---------PKVV 823

  Fly  1085 VVKSNYLQYPVEPI----------NWSEFLPPPPEHPPPSSTYGYAQGSPESSRKSSKSAGSGIS 1139
            |.|...|..|...:          .|.     ||.........||..   :..|:.:..|...::
  Rat   824 VTKGAVLGRPTLSVQQTPEGSLLARWE-----PPADAAEDPVLGYRL---QFGREDAAPATLELA 880

  Fly  1140 TNQSILNASIHSS-------SSGGFSAWGVSPQYAVACPPENVYSNPLSAVAGGTQNRYQITPTN 1197
            ..:....|..|..       ::.|.:..|.....|::.|.:.....|  .:.|...|....:...
  Rat   881 AWERRFAAPAHKGATYVFRLAARGRAGLGEEASAALSIPEDAPRGFP--QILGAAGNVSAGSVIL 943

  Fly  1198 QHPPQLPA--------YFATTGPGGAVPPNHLPFATQRHAASEYQAGLNAARCAQSRACNSCDAL 1254
            :..|.:||        |..:....||..|     ||:...|:..|.|...|...|.....:...|
  Rat   944 RWLPPVPAERNGAIIKYTVSVREAGAPGP-----ATETELAAAAQPGAETALTLQGLRPETAYEL 1003

  Fly  1255 AT-------PSPMQPPPPVPVPEGWYQPVHPNSHPMHPTSSNHQIYQCSSECSDHSRSSQSHKRQ 1312
            ..       |.|..||....:..   .||.|.:..:........:  .|.|..|:..|...:|.|
  Rat  1004 RVRAHTRRGPGPFSPPLRYRLAR---DPVSPKNFKVKMIMKTSVL--LSWEFPDNYNSPTPYKIQ 1063

  Fly  1313 ---LQLEEHGSSAKQ 1324
               |.|:..|.:.|:
  Rat  1064 YNGLTLDVDGRTTKK 1078

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.