DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and Iglon5

DIOPT Version :9

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:NP_001157990.1 Gene:Iglon5 / 210094 MGIID:2686277 Length:336 Species:Mus musculus


Alignment Length:329 Identity:85/329 - (25%)
Similarity:134/329 - (40%) Gaps:72/329 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 GQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARILH-------------------DEKSLEISNI 314
            |..||..|.: .:...:|.|        ::|:.||:                   :|.|:.|:.:
Mouse    47 GDNATLSCFI-DEHVTRVAW--------LNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITQV 102

  Fly   315 TPTDEGTYVCEAHNNVGQISARASLIVHAPPNFTKRPSNKKVGLNGVVQLPCMASGNPPPSVFW- 378
            ...|||.|.|.........:.:..||||.|.......|...|...|.|.|.|:|.|.|.|:|.| 
Mouse   103 GLGDEGLYTCSFQTRHQPYTTQVYLIV
HVPARIVNISSPVAVNEGGNVNLLCLAVGRPEPTVTWR 167

  Fly   379 -TKEGVSTLMFPNSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSS--TVRVFLQVSSLD 440
             .::|.       :|.|.       .|:|:|:::...|.|.|...:.|:|:  :.||.:.|:   
Mouse   168 QLRDGF-------TSEGE-------ILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVN--- 215

  Fly   441 ERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHDGHAVQAGNRYSI-IQ----GSSLR 500
             .||.|..:..|...|  |..|.|.|.|...|....:|:.|...:.:|:...: :|    .|.|.
Mouse   216 -YPPTITDVTSARTAL--GRAALLRCEAMAVPPADFQWYKDDRLLSSGSAEGLKVQTERTRSMLL 277

  Fly   501 VDDLQLSDSGTYTCTASGERGETSWAATLTVEKPGSTSLHRAADPSTYPAPPGTPKVLNVSRTSI 565
            ..::.....|.|||.|:...|.:|  |::.:.:||  ||..:|     |.|||...:|:      
Mouse   278 FANVSARHYGNYTCRAANRLGASS--ASMRLLRPG--SLENSA-----PRPPGPLTLLS------ 327

  Fly   566 SLRW 569
            :|.|
Mouse   328 ALSW 331

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:299845
I-set 56..150 CDD:254352
I-set 157..251 CDD:254352
Ig2_Robo 159..251 CDD:143201
I-set 255..341 CDD:254352 18/90 (20%)
Ig3_Robo 272..341 CDD:143202 17/87 (20%)
IG_like 351..436 CDD:214653 25/88 (28%)
Ig 362..444 CDD:299845 23/85 (27%)
I-set 445..531 CDD:254352 23/90 (26%)
IGc2 459..521 CDD:197706 17/66 (26%)
FN3 549..637 CDD:238020 7/21 (33%)
FN3 673..762 CDD:238020
fn3 770..855 CDD:278470
Iglon5NP_001157990.1 Ig 41..129 CDD:416386 18/90 (20%)
Ig strand A' 41..46 CDD:409353
Ig strand B 48..56 CDD:409353 3/7 (43%)
CDR1 56..60 CDD:409353 0/4 (0%)
FR2 61..68 CDD:409353 2/14 (14%)
Ig strand C 61..67 CDD:409353 2/13 (15%)
CDR2 69..79 CDD:409353 2/9 (22%)
Ig strand C' 71..74 CDD:409353 2/2 (100%)
Ig strand C' 76..79 CDD:409353 0/2 (0%)
FR3 80..115 CDD:409353 8/34 (24%)
Ig strand D 84..91 CDD:409353 0/6 (0%)
Ig strand E 94..100 CDD:409353 2/5 (40%)
Ig strand F 107..115 CDD:409353 4/7 (57%)
CDR3 116..120 CDD:409353 0/3 (0%)
Ig strand G 120..129 CDD:409353 1/8 (13%)
FR4 122..129 CDD:409353 1/6 (17%)
Ig strand A 132..137 CDD:409353 1/4 (25%)
Ig_3 134..199 CDD:404760 21/78 (27%)
Ig strand A' 140..145 CDD:409353 1/4 (25%)
Ig strand B 148..157 CDD:409353 4/8 (50%)
Ig strand C 163..167 CDD:409353 1/3 (33%)
Ig strand D 174..177 CDD:409353 1/2 (50%)
Ig strand E 178..183 CDD:409353 1/11 (9%)
Ig strand F 191..199 CDD:409353 3/7 (43%)
Ig_3 217..295 CDD:404760 22/79 (28%)
putative Ig strand A 218..224 CDD:409353 2/5 (40%)
Ig strand B 234..238 CDD:409353 2/3 (67%)
Ig strand C 247..251 CDD:409353 0/3 (0%)
Ig strand E 274..278 CDD:409353 2/3 (67%)
Ig strand F 288..293 CDD:409353 3/4 (75%)
Ig strand G 301..304 CDD:409353 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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