DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo1 and Dcc

DIOPT Version :9

Sequence 1:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster
Sequence 2:	NP_031857.2	Gene:	Dcc / 13176	MGIID:	94869	Length:	1447	Species:	Mus musculus

Alignment Length:	1203	Identity:	279/1203 - (23%)
Similarity:	432/1203 - (35%)	Gaps:	310/1203 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LLLVLVASNGLPA---VRG----QYQSPRIIEHPTDLVVKKNEPATLNCKVEG-KPEPTIEWFKD 92
            |..||..::.|.|   |.|    .:.|...:..|:|.|..:.....|||..|. :..|.|:|.||
Mouse    13 LAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCSAESDRGVPVIKWKKD 77

  Fly    93 G--EPVSTNEKKSHRVQFKDGALFFYRTMQGKKEQ-DGGEYWCVAK-NRVGQAVSRHASLQIA-V 152
            |  ..:..:::|.   |..:|:|.....:..:..: |.|.|.|.|. ...|..:||.|.:.:| .
Mouse    78 GLILALGMDDRKQ---QLPNGSLLIQNILHSRHHKPDEGLYQCEASLADSGSIISRTAKVTVAGP 139

  Fly   153 LRDDFRVEPKDTRVAKGETALLECGPPKGIPEPTLIWIKDGVPLDDLKAMSFGASSRVRIVDGGN 217
            ||  |..:.:......|:|.||:| ...|.|.||:.|.|:...|:.|.     ..|||.::..|.
Mouse   140 LR--FLSQTESITAFMGDTVLLKC-EVIGEPMPTIHWQKNQQDLNPLP-----GDSRVVVLPSGA 196

  Fly   218 LLISNVEPIDEGNYKCIAQNLVGTRESSYAKLIVQVKP------YFMKEPKDQVMLYGQTATFHC 276
            |.||.::|.|.|.|:|.|:|....|..:.|::.:...|      ||::.|.:.:.:.|:.|...|
Mouse   197 LQISRLQPGDSGVYRCSARNPASIRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLEC 261

  Fly   277 SVGGDPPPKVLWKKEEGNIPV-SRARILHDEKSLEISNITPTDEGTYVCEAHNNVGQISARASLI 340
            .|.|.|||...|.:.|..|.: |:...|....:|.|||:|..|.|||.|........|||.|.|.
Mouse   262 CVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAELT 326

  Fly   341 VHAPPNFTKRPSNKKVGLNGVVQLPCMASGNPPPSVFWTKEGVSTLMFPNSSHGRQHVAADGTLQ 405
            |..||.|...|||                       .:..|.:
Mouse   327 VLVPPWFLNHPSN-----------------------LYAYESM---------------------- 346

  Fly   406 ITDVRQEDEGYYVCSAFSVVDSSTVRVFLQVSSLDERPPPIIQIGPANQTLPKGSVATLPCRATG 470
              |:..|                                                     |..:|
Mouse   347 --DIEFE-----------------------------------------------------CAVSG 356

  Fly   471 NPSPRIKWFHDGHAVQAGNRYSIIQGSSLRVDDLQLSDSGTYTCTASGERGETSWAATLTVEKPG 535
            .|.|.:.|..:|..|...:.:.|:.||:||:..:..||.|.|.|.|..|.|....:|.|.|.||.
Mouse   357 KPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQLIVPKPA 421

  Fly   536 STSLHRAADPSTYPAPPGTPKVLNVSRTSISLRWAKSQEKPGAVGPIIGYTVEYFSPD------- 593
            ..|      .|..|:.|.....:.||...:.|.|....|   |.|.|..:|| :||.:
Mouse   422 IPS------SSILPSAPRDVLPVLVSSRFVRLSWRPPAE---AKGNIQTFTV-FFSREGDNRERA 476

  Fly   594 LQTGWIVAAQRVGDTQVTISGLTPGTSYVFLVRAENTQGISVPSGLSNTIKTIEADFDAASANDL 658
            |.|      .:.|..|:|:..|.|...|.|.|.|.|..|   |...|..||             :
Mouse   477 LNT------TQPGSLQLTVGNLKPEAMYTFRVVAYNEWG---PGESSQPIK-------------V 519

  Fly   659 SAARTLLTGKSVELIDASAINASAVRLEWMLHVSADEKYVEGLRIHYKDASVPSAQYHSITVMDA 723
            :....|.....||.:.|.:.:.:::.:.|.....|:.. |:|.|:...:.|....|.     ::.
Mouse   520 ATQPELQVPGPVENLHAVSTSPTSILITWEPPAYANGP-VQGYRLFCTEVSTGKEQN-----IEV 578

  Fly   724 SAESFVVGNLKKYTKYEFFLTPFFETIEGQPSNSKTALTYEDVPSAPPDNIQIGMYNQTAGWVRW 788
            ...|:.:..|||:|:|......:.....|..::..|.:|..|||||||.||.:.:.|..:..|.|
Mouse   579 DGLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSW 643

  Fly   789 TPPPSQHHNGNLYGYKI---EVSAGNTMKVLANMTLNATTTSVLLNNLTTGAVYSVRLNSFTKAG 850
            .||||...||.:.||||   :.:....|:     ||.......|...|..|:.||.::::.|..|
Mouse   644 LPPPSGTQNGFITGYKIRHRKTTRRGEME-----TLEPNNLWYLFTGLEKGSQYSFQVSAMTVNG 703

  Fly   851 DGPYSKPISLFMDPTHHVHPPRAHPSGTHDGRHEGQDLTYHNNGNIP--PGD--INPTTHKKTTD 911
            .||                     ||..:.......||   :...:|  |..  :.|.|:
Mouse   704 TGP---------------------PSNWYTAETPENDL---DESQVPDQPSSLHVRPQTN----- 739

  Fly   912 YLSGPWLMVLVCIVLLVLVISAAISMVYFKRKHQMTKELGHLSVVSDNEITALNINS--KESLWI 974
                       ||::                  ..|..| :.::|....|....:.|  .|::.:
Mouse   740 -----------CIIM------------------SWTPPL-NPNIVVRGYIIGYGVGSPYAETVRV 774

  Fly   975 DHHRGWRTADTDKDSGLSESKLLSHVNSSQSNYNNSDGGTD-YAEVDTRNLTTFYNCRKSPDNPT 1038
            |..:.:.:.:..:.|        ||...|...:||:..|.. |....||::|       .|.:|.
Mouse   775 DSKQRYYSIERLESS--------SHYVISLKAFNNAGEGVPLYESATTRSIT-------DPTDPV 824

  Fly  1039 PYATTMIIGTSSSETCTKTTSISADKDSGTHSPYSDAFAGQVPAVPVVKSNYLQYPVEPINWSEF 1103
            .|...:                   .|..|..|  |.....:|.|. |::..|.:....::|::.
Mouse   825 DYYPLL-------------------DDFPTSGP--DVSTPMLPPVG-VQAVALTHEAVRVSWADN 867

  Fly  1104 LPPPPEHPPPSSTYGYAQGSPESSRKSSKSAGSGISTNQSILNASIHSSSSGGFSAWGVSP---- 1164
            ..|..:.......|.....:..|:....||                ..::|..::|.|:.|
Mouse   868 SVPKNQKTSDVRLYTVRWRTSFSASAKYKS----------------EDTTSLSYTATGLKPNTMY 916

  Fly  1165 QYAVACPPENVYSNPLSAVAGGTQNRYQITPTN 1197
            :::|.. .:|..|:..|..|..|  .|:..||:
Mouse   917 EFSVMV-TKNRRSSTWSMTAHAT--TYEAAPTS 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo1	NP_476899.1	Ig	56..151	CDD:299845	26/99 (26%)
		I-set	56..150	CDD:254352	26/98 (27%)
		I-set	157..251	CDD:254352	30/93 (32%)
		Ig2_Robo	159..251	CDD:143201	29/91 (32%)
		I-set	255..341	CDD:254352	32/92 (35%)
		Ig3_Robo	272..341	CDD:143202	27/69 (39%)
		IG_like	351..436	CDD:214653	6/84 (7%)
		Ig	362..444	CDD:299845	3/81 (4%)
		I-set	445..531	CDD:254352	22/85 (26%)
		IGc2	459..521	CDD:197706	19/61 (31%)
		FN3	549..637	CDD:238020	27/94 (29%)
		FN3	673..762	CDD:238020	16/88 (18%)
		fn3	770..855	CDD:278470	29/87 (33%)
Dcc	NP_031857.2	Ig1_Neogenin	42..136	CDD:143199	26/96 (27%)
		IG_like	46..136	CDD:214653	26/92 (28%)
		IG_like	147..224	CDD:214653	28/82 (34%)
		IGc2	153..219	CDD:197706	27/71 (38%)
		I-set	241..327	CDD:254352	31/85 (36%)
		Ig	244..327	CDD:299845	29/82 (35%)
		I-set	331..417	CDD:254352	30/185 (16%)
		Ig	347..417	CDD:299845	24/122 (20%)
		FN3	429..521	CDD:238020	31/117 (26%)
		FN3	528..617	CDD:238020	18/94 (19%)
		FN3	625..715	CDD:238020	31/115 (27%)
		FN3	726..805	CDD:214495	19/121 (16%)
		FN3	846..939	CDD:238020	20/112 (18%)
		FN3	946..1041	CDD:238020	0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1153
		Neogenin_C	1148..1445	CDD:284094
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1166..1220
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1291..1329
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1394..1419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910