DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment robo1 and AgaP_AGAP003108

DIOPT Version :9

Sequence 1:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster
Sequence 2:	XP_562866.4	Gene:	AgaP_AGAP003108 / 1273778	VectorBaseID:	AGAP003108	Length:	941	Species:	Anopheles gambiae

Alignment Length:	464	Identity:	107/464 - (23%)
Similarity:	153/464 - (32%)	Gaps:	130/464 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GLPAVRGQYQSPRIIEHPTDLVVKKNEPATLNCKVEGKPEPTIEWFKDGEPVSTNEKKSHRVQFK 109
            |.|.:.|....|    :|:.:|....|...|.|...|:|.|.:.|.|||.....|..|| .:.||
Mosquito    82 GPPRILGTRDEP----YPSPVVRGVGEAYRLKCDAVGQPAPHVSWLKDGAEYRDNSYKS-TIVFK 141

  Fly   110 DGALFFYRTMQGKKEQDGGEYWCVAKNRVG-----------------------QAVSRHASLQIA 151
            .           ....|.|.|.|...|..|                       ..:..|:.||..
Mosquito   142 Q-----------LLPTDAGTYVCNVCNVYGCVNATTVLEVVESGEHEPAYIQHNTMESHSQLQGD 195

  Fly   152 VLRDDFRV-----------------------EPKDTRVAK-----GETALLECGPPKGIPEPTLI 188
            ....|.:|                       :|:|..:.:     ||....|.||..|
Mosquito   196 PATQDTQVMMRALGRYYPAGATEKRPQHHTYQPEDADMDEDEDEDGEEEEEEEGPTNG------- 253

  Fly   189 WIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSYAKLIVQV 253
               .||...|....|.||      |:|     |...|.|..
Mosquito   254 ---TGVHGSDTTEDSAGA------VNG-----SGTPPPDRA------------------------ 280

  Fly   254 KPYFMKEPKDQVMLY-----GQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARILHDEKSLEISN 313
             |.|.|  |||:...     |......|...|.|.|.:.|.|:...|..:..::.....::.:.:
Mosquito   281 -PIFTK--KDQMTKIVSKPSGNMVRLRCPADGYPKPNITWTKDGRKIERAMGQVKKVNWAIVLED 342

  Fly   314 ITPTDEGTYVCEAHNNVGQISARASLIVH----APPNFTKRPSNKKVGLNGVVQLPCMASGNPPP 374
            :.|.|.|:|.|...|.||.|:....|.|.    |.|:.|:||.|....:|..|...|....:..|
Mosquito   343 LVPQDSGSYTCAVCNQVGCINFTTKLEVKDRFPARPHITERPKNVTALVNTTVIFSCPILSDLEP 407

  Fly   375 SVFWTKEG---VSTLMFP-NSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQ 435
            .:.|.|.|   :..:..| |.:..::.......|.:.:|...|||:|.|.|.:.:.::....:||
Mosquito   408 HIEWVKLGLVDLENMSIPENVTKLKRDPDNPEVLTLENVTHADEGWYTCIAANSLGATNESAYLQ 472

  Fly   436 VSSLDERPP 444
            |  |||.||
Mosquito   473 V--LDELPP 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo1	NP_476899.1	Ig	56..151	CDD:299845	27/117 (23%)
		I-set	56..150	CDD:254352	26/116 (22%)
		I-set	157..251	CDD:254352	20/121 (17%)
		Ig2_Robo	159..251	CDD:143201	20/119 (17%)
		I-set	255..341	CDD:254352	24/90 (27%)
		Ig3_Robo	272..341	CDD:143202	17/68 (25%)
		IG_like	351..436	CDD:214653	20/88 (23%)
		Ig	362..444	CDD:299845	22/85 (26%)
		I-set	445..531	CDD:254352	107/464 (23%)
		IGc2	459..521	CDD:197706
		FN3	549..637	CDD:238020
		FN3	673..762	CDD:238020
		fn3	770..855	CDD:278470
AgaP_AGAP003108	XP_562866.4	I-set	95..170	CDD:254352	23/86 (27%)
		Ig	98..170	CDD:299845	22/83 (27%)
		Ig	291..370	CDD:299845	18/78 (23%)
		IG_like	293..370	CDD:214653	18/76 (24%)
		IG_like	384..473	CDD:214653	20/88 (23%)
		Ig	393..474	CDD:299845	19/82 (23%)
		PKc_like	590..880	CDD:304357
		STYKc	602..875	CDD:214568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910