DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment robo1 and AgaP_AGAP011194

DIOPT Version :9

Sequence 1:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster
Sequence 2:	XP_309450.4	Gene:	AgaP_AGAP011194 / 1270731	VectorBaseID:	AGAP011194	Length:	470	Species:	Anopheles gambiae

Alignment Length:	430	Identity:	104/430 - (24%)
Similarity:	164/430 - (38%)	Gaps:	106/430 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 VKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARILHDEK-------SLE 310
            |:|.|....:....:.|.|.|..|.|.......:||::....:..:...|..|.:       ||:
Mosquito    30 VQPKFTSRSQSVRAVIGDTITLPCEVENLGRNILLWRRGSAVVTAANLIITRDTRFKLLEGYSLQ 94

  Fly   311 ISNITPTDEGTYVCEA--HNNVGQISARASLIVHAPPNFTKRPSNKKVGL--NGVVQLPCMASGN 371
            |.|:.|.|.|.|.|:.  |:|...:.....|:   ||:....|....|.:  .|...|.|.||||
Mosquito    95 IKNVRPQDAGDYNCQIGDHDNRDLVHTVEILV---PPSVRSNPETGHVTVRKGGTATLECKASGN 156

  Fly   372 PPPSVFWTKEGVSTLMFPNSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQV 436
            |.||:.||::        :|.||..|::...||.:.:|.::|.|.|.|.|.:.: ...|.|.:|:
Mosquito   157 PVPSISWTRK--------DSIHGSPHLSEGPTLTLENVNRQDSGTYRCYADNGI-REPVFVDMQL 212

  Fly   437 SSLDERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHDGHAVQAGNRYSI-IQGSS-- 498
            ..|.   ||.|.:..:.....:|..|.|.|...|:.:|.:.|:.|...:...:|.:: .:|..
Mosquito   213 IVLS---PPEITVEKSWVHAGEGYEAQLVCTVHGDANPEVMWYQDSFLLHPNDRRTMDTRGEKHY 274

  Fly   499 LRVDDLQLSDSGTYTCTASGERGETSWAATLTVE---KPGSTSLHRAADP--STYPAPPGTPKVL 558
            |.|.:::.||.|.|:|.|....|.    |...:|   :||....|   .|  |.|
Mosquito   275 LTVRNVRASDFGNYSCVAENSLGR----AKKYIEVSGRPGPAQFH---SPMYSRY---------- 322

  Fly   559 NVSRTSISLRWA--------------------KSQEKPGAVGPII-----------GYTVEYFSP 592
               |...:|.|:                    ::.:.||....||           .:.:.|
Mosquito   323 ---REMYNLTWSIESFPLIEEIRLLYRKLMMNETFQHPGRWHDIILNPPSTRSESFRHIMTY--- 381

  Fly   593 DLQTGWIVAAQRVGDTQVTISGLTPGTSYVFLVRAENTQG 632
                              ||.||.|.:.|..:|:|:|..|
Mosquito   382 ------------------TIKGLDPNSVYETIVQAKNRYG 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo1	NP_476899.1	Ig	56..151	CDD:299845
		I-set	56..150	CDD:254352
		I-set	157..251	CDD:254352
		Ig2_Robo	159..251	CDD:143201
		I-set	255..341	CDD:254352	23/94 (24%)
		Ig3_Robo	272..341	CDD:143202	19/77 (25%)
		IG_like	351..436	CDD:214653	28/86 (33%)
		Ig	362..444	CDD:299845	27/81 (33%)
		I-set	445..531	CDD:254352	22/88 (25%)
		IGc2	459..521	CDD:197706	18/64 (28%)
		FN3	549..637	CDD:238020	18/115 (16%)
		FN3	673..762	CDD:238020
		fn3	770..855	CDD:278470
AgaP_AGAP011194	XP_309450.4	IG_like	38..126	CDD:214653	20/87 (23%)
		Ig	49..110	CDD:143165	16/60 (27%)
		IG_like	137..214	CDD:214653	28/85 (33%)
		IGc2	144..200	CDD:197706	24/63 (38%)
		I-set	218..305	CDD:254352	22/90 (24%)
		Ig	235..304	CDD:143165	19/72 (26%)
		FN3	<357..415	CDD:238020	15/68 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910