DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and Chl1

DIOPT Version :10

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:XP_006505530.1 Gene:Chl1 / 12661 MGIID:1098266 Length:1225 Species:Mus musculus


Alignment Length:1248 Identity:275/1248 - (22%)
Similarity:448/1248 - (35%) Gaps:338/1248 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 WLLLVLVASNGLPAVRGQYQSPRIIEHP-TDLVVKKNEPATLNCKVEGKPEPTIEWFKDGEPVST 98
            :|||.|.|:....:|:   |.|.|::.. ..:....:|...:.|:.:|.|||...|.||.:|...
Mouse    17 FLLLKLSAAEIPLSVQ---QVPTIVKQSYVQVAFPFDEYFQIECEAKGNPEPIFSWTKDDKPFDL 78

  Fly    99 NEKKSHRVQFKDGALFFYRTMQGKKEQDGGEYWCVAKNRVGQAVSRHASLQIAVLRDDF---RVE 160
            ::.   |:...:.:..|....:|......|:|.|.|.||:|.|||......:..: ..|   ::|
Mouse    79 SDP---RIIAANNSGTFKIPNEGHISHFQGKYRCFASNRLGTAVSEEIEFIVPGV-PKFPKEKIE 139

  Fly   161 PKDTRVAKGETALLECGPPKGIPEPTLIWIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISNVEP 225
            |.|  |.:|::.:|.|.||||:|...:.|:  .:.|:.::     ...||.:...|:|..:|||.
Mouse   140 PID--VEEGDSIVLPCNPPKGLPPLHIYWM--NIELEHIE-----QDERVYMSQRGDLYFANVEE 195

  Fly   226 IDEGN-YKCIA-----QNLV--------------------GTRESSYAKLIVQVKPYFMKEPKD- 263
            .|..| |.|.|     :.:|                    .|...|.|..|.|.||..:..|.. 
Mouse   196 NDSRNDYCCFAAFPKLRTIVQKMPMKLTVNSLKHASDSSSSTEICSQANSIKQRKPKLLLPPAQM 260

  Fly   264 -----QVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARILHDEKSLEISNITPTDEGTYV 323
                 :.:|.|.|....|...|.|.|.:.|.|....:|..||.|...||:|:|.||:..|.|.|.
Mouse   261 GSLSAKTVLKGDTLLLECFAEGLPTPHIQWSKPGSELPEGRATIEVHEKTLKIENISYQDRGNYR 325

  Fly   324 CEAHNNVGQISARASLIVHAPPNFTKRPSNK--KVGLNGVVQLPCMASGNPPPSVFWTKEGV--- 383
            |.|:|.:|:.|....:.|..||.:.|:|.:.  ..|.:|:  |.|.|.|.|.|::.|...|:   
Mouse   326 CTANNLLGKASHDFHVTVEEPPRWKKKPQSAVYSTGSSGI--LLCEAEGEPQPTIKWRLNGLPIE 388

  Fly   384 -----STLMFP--------------------NSSHG----------------------------- 394
                 ...|||                    ::.||                             
Mouse   389 KHPFPGDFMFPREISFTNLLPNHTGVYQCEASNIHGTILANANIDVIDVIPLIKTKNEENYATVV 453

  Fly   395 --------------------------------RQHVAADGTLQITDVRQEDEGYYVCSAFSVVDS 427
                                            |.|...:|||:|....:||.|.|.|...:.:..
Mouse   454 GYSAFLHCEYFASPKATVVWEVADETHPLEGDRYHTHENGTLEIYRTTEEDAGSYSCWVDNAMGK 518

  Fly   428 STVRVFLQVSSLDERPPPIIQIGPANQTLPKGSVATLPCRATGNP----SPRIKWFHDGHAVQAG 488
            :.:     .::||.|....:::.|.|..:||..|..|.|.:..:.    |.::.|..||.|.:..
Mouse   519 AVI-----TANLDIRNATKLRVSPKNPRIPKSHVLELYCESQCDSHLKHSLKLSWSKDGEAFEMN 578

  Fly   489 NRYS---IIQGSSLRVDDLQLSDSGTYTCTASGERGETSWAATLTVEKPGSTSLHRAADPSTYPA 550
            ....   :|.|:.|.:.::...|.|.|:|:|......||....:||              ...|.
Mouse   579 GTEDGRIVIDGAYLTISNITAEDQGVYSCSAQTSLDSTSEKTQVTV--------------LGVPD 629

  Fly   551 PPGTPKVLNVSRTSISLRWAKSQEKPGAVGPIIGYTVEYFSPDLQTG-WIVAAQRVGDTQVTISG 614
            |||...:......|:.|.|....:....:..   |.||:.....:.| |....:..|:....:..
Mouse   630 PPGNLHLSERQNRSVRLSWEAGDDHNSKISE---YIVEFEGNREEPGKWEELTRVQGEETDVVLS 691

  Fly   615 LTPGTSYVFLVRAENTQG---ISVPS--------------------------------------- 637
            |.|...|.|.|.|.|..|   .|:||                                       
Mouse   692 LAPYVRYQFRVTAVNEVGRSHASLPSDHHETPPAAPDKNPQNIRVQASQPKEMIIKWEPLKSMEQ 756

  Fly   638 ---GL---------------------SNTIK----TIEADFD--AASANDLSAAR-----TLLTG 667
               ||                     ::|::    |:.|.:|  ..:.|.|.::.     ||.:|
Mouse   757 NGPGLEYKVSWKPQGAPEEWEEEIVTNHTLRVMTPTVYAPYDVKVQAINQLGSSPDPQPVTLYSG 821

  Fly   668 KS-------VELIDASAINASAVRLEWMLHVSADEKYVEGLRIHY-----KDASVPSAQYH--SI 718
            :.       ::.:|  .:|::.|::.|.   |..::.|.||...|     |..|:...:.|  .:
Mouse   822 EDYPSTAPVIQRVD--VMNSTLVKVTWS---SIPKETVHGLLRGYQINWWKTKSLLDGRTHPKEV 881

  Fly   719 TVMDASAE--SFVVGNLKKYTKYEFFLTPFFETIEGQPSNSKTAL--TYEDVPSAPPDNIQIGMY 779
            .::..|.:  |.:|.:|..::  ||.||......:|....|:..:  |.|.||. .|..:::...
Mouse   882 NILRFSGQRNSGMVPSLDPFS--EFHLTVLAYNSKGAGPESEPYIFQTPEGVPE-QPSFLKVIKV 943

  Fly   780 NQTAGWVRWTPPPSQHHNGNLYGYKIEVSAGNTMKVLANMT-LNATT---TSVLLNNLTTGAVYS 840
            ::....:.|..|  :..||||.||.::....|....|..:. :|.||   :|..|:||.:...|.
Mouse   944 DKDTATLSWGLP--KKLNGNLTGYLLQYQIINDTYELGELNEINVTTPSKSSWHLSNLNSTTKYK 1006

  Fly   841 VRLNSFTKAGDGPYSKPIS-----------------LFMDPTHHVHPPRAHPSGTHDGRHEGQDL 888
            ..|.:.|..|.|   ||||                 ..::.|..:||......|.....|    |
Mouse  1007 FYLRACTSRGCG---KPISEEGATLGEGSKGIRKITEGVNVTQKIHPVEVLVPGAEHIVH----L 1064

  Fly   889 TYHNNGNIPP--GDINPTTHKKTT----DYLSGPWLMVLVC-IVLLVLVISAAISMVYFKRKHQM 946
            ...|.|:...  .|:..|..::..    |..:..|.:.|:| |.||.|::   :::.:.||    
Mouse  1065 MTKNWGDNDSIFQDVIETRGREYAGLYDDISTQGWFIGLMCAIALLTLIL---LTICFVKR---- 1122

  Fly   947 TKELGHLSVVSDNEITALNINSKESLWIDHHRGWRTADTDKDSGLSESK----LLSHVNSSQSNY 1007
                        |.....::..||.|..|........:|..:...|:.|    .|..:|.:....
Mouse  1123 ------------NRGGKYSVKEKEDLHPDPEVQSAKDETFGEYSDSDEKPLKGSLRSLNRNMQPT 1175

  Fly  1008 NNSDGGTDYAEVD 1020
            .::|...:|.|.|
Mouse  1176 ESADSLVEYGEGD 1188

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:472250 25/95 (26%)
Ig strand B 73..77 CDD:409353 0/3 (0%)
Ig strand C 86..90 CDD:409353 0/3 (0%)
Ig strand E 111..115 CDD:409353 0/3 (0%)
Ig strand F 129..134 CDD:409353 2/4 (50%)
Ig strand G 143..146 CDD:409353 1/2 (50%)
IgI_2_Robo 158..251 CDD:409389 30/118 (25%)
Ig strand A 158..161 CDD:409389 0/2 (0%)
Ig strand A' 163..167 CDD:409389 1/3 (33%)
Ig strand B 171..178 CDD:409389 2/6 (33%)
Ig strand C 186..191 CDD:409389 1/4 (25%)
Ig strand C' 193..196 CDD:409389 0/2 (0%)
Ig strand D 209..213 CDD:409389 2/3 (67%)
Ig strand E 216..222 CDD:409389 2/5 (40%)
Ig strand F 229..237 CDD:409389 4/13 (31%)
Ig strand G 240..251 CDD:409389 3/10 (30%)
IgI_3_Robo 258..341 CDD:409390 28/88 (32%)
Ig strand A 258..261 CDD:409390 0/2 (0%)
Ig strand A' 263..267 CDD:409390 0/9 (0%)
Ig strand B 270..279 CDD:409390 2/8 (25%)
Ig strand C 285..290 CDD:409390 1/4 (25%)
Ig strand C' 293..296 CDD:409390 0/2 (0%)
Ig strand D 299..304 CDD:409390 3/4 (75%)
Ig strand E 305..313 CDD:409390 4/7 (57%)
Ig strand F 320..328 CDD:409390 4/7 (57%)
Ig strand G 331..341 CDD:409390 2/9 (22%)
Ig 346..437 CDD:472250 28/181 (15%)
Ig strand B 362..366 CDD:409353 1/3 (33%)
Ig strand C 375..379 CDD:409353 0/3 (0%)
Ig strand E 402..406 CDD:409353 3/3 (100%)
Ig strand F 416..421 CDD:409353 2/4 (50%)
Ig strand G 429..432 CDD:409353 0/2 (0%)
Ig 446..531 CDD:472250 22/91 (24%)
Ig strand B 462..466 CDD:409544 1/3 (33%)
Ig strand C 475..479 CDD:409544 0/3 (0%)
Ig strand E 497..501 CDD:409544 1/3 (33%)
FN3 507..>916 CDD:442628 108/531 (20%)
Ig strand F 511..516 CDD:409544 2/4 (50%)
Ig strand G 524..527 CDD:409544 1/2 (50%)
FN3 549..637 CDD:238020 22/91 (24%)
fn3 770..855 CDD:394996 23/88 (26%)
Chl1XP_006505530.1 Ig 35..126 CDD:472250 25/93 (27%)
Ig strand B 53..57 CDD:409396 0/3 (0%)
Ig strand C 66..70 CDD:409396 0/3 (0%)
Ig strand E 90..94 CDD:409396 1/3 (33%)
Ig strand F 106..111 CDD:409396 2/4 (50%)
Ig strand G 120..123 CDD:409396 1/2 (50%)
IgI_2_L1-CAM_like 135..225 CDD:409432 27/98 (28%)
Ig strand A 135..138 CDD:409432 0/2 (0%)
Ig strand A' 140..144 CDD:409432 2/5 (40%)
Ig strand B 147..155 CDD:409432 2/7 (29%)
Ig strand C 162..168 CDD:409432 1/7 (14%)
Ig strand C' 171..174 CDD:409432 1/2 (50%)
Ig strand D 180..184 CDD:409432 1/3 (33%)
Ig strand E 186..190 CDD:409432 2/3 (67%)
Ig strand F 201..209 CDD:409432 3/7 (43%)
Ig strand G 212..225 CDD:409432 1/12 (8%)
Ig 262..344 CDD:472250 27/81 (33%)
Ig strand B 274..278 CDD:409394 0/3 (0%)
Ig strand C 287..291 CDD:409394 0/3 (0%)
Ig strand E 309..313 CDD:409394 2/3 (67%)
Ig strand F 323..328 CDD:409394 2/4 (50%)
Ig strand G 336..339 CDD:409394 1/2 (50%)
Ig4_L1-NrCAM_like 348..435 CDD:409367 17/88 (19%)
Ig strand B 364..368 CDD:409367 2/5 (40%)
Ig strand C 377..381 CDD:409367 0/3 (0%)
Ig strand E 400..404 CDD:409367 0/3 (0%)
Ig strand F 414..419 CDD:409367 0/4 (0%)
Ig strand G 427..430 CDD:409367 0/2 (0%)
Ig 448..525 CDD:472250 11/81 (14%)
Ig strand B 457..461 CDD:409390 0/3 (0%)
Ig strand C 470..474 CDD:409390 0/3 (0%)
Ig strand E 493..497 CDD:409390 3/3 (100%)
Ig strand F 507..512 CDD:409390 2/4 (50%)
Ig strand G 520..523 CDD:409390 0/7 (0%)
IG_like 548..624 CDD:214653 17/75 (23%)
Ig strand B 548..552 CDD:409440 1/3 (33%)
Ig strand C 565..569 CDD:409440 0/3 (0%)
Ig strand E 588..594 CDD:409440 2/5 (40%)
FN3 <591..>868 CDD:442628 54/298 (18%)
Ig strand F 604..609 CDD:409440 2/4 (50%)
Ig strand G 617..620 CDD:409440 1/2 (50%)
FN3 628..717 CDD:238020 22/91 (24%)
FN3 833..927 CDD:238020 22/100 (22%)
FN3 932..1027 CDD:238020 28/100 (28%)
Bravo_FIGEY 1121..1206 CDD:464016 16/84 (19%)

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