DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and GPA33

DIOPT Version :9

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:NP_005805.1 Gene:GPA33 / 10223 HGNCID:4445 Length:319 Species:Homo sapiens


Alignment Length:249 Identity:58/249 - (23%)
Similarity:92/249 - (36%) Gaps:66/249 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   323 VCEAHNNVGQISARASLIVHAPPNFTKRPSNKKVGLNGVVQLPC---MASGNPPPSVFWTK---- 380
            :|.....|..||      |..|.:..:....|.      |.|||   .::.:....:.|.|    
Human    12 LCAVRVTVDAIS------VETPQDVLRASQGKS------VTLPCTYHTSTSSREGLIQWDKLLLT 64

  Fly   381 --EGVSTLMFPNSS--HG---RQHVA-------ADGTLQITDVRQEDEGYYVCSAFSVVD----- 426
              |.|....|.|.:  ||   :..|:       :|.::.|..:...|.|.|.||...:.|     
Human    65 HTERVVIWPFSNKNYIHGELYKNRVSISNNAEQSDASITIDQLTMADNGTYECSVSLMSDLEGNT 129

  Fly   427 SSTVRVFLQVSSLDERPPPIIQIGPANQTLPKGSVATLPCRA-TGNPSPRIKWFHDGHAVQAGNR 490
            .|.||:.:.|      ||...:.|...:|: .|:...|.|:: .|:|:|:..|          .|
Human   130 KSRVRLLVLV------PPSKPECGIEGETI-IGNNIQLTCQSKEGSPTPQYSW----------KR 177

  Fly   491 YSII----------QGSSLRVDDLQLSDSGTYTCTASGERGETSWAATLTVEKP 534
            |:|:          .|..:.:.::....||.|.||:|.|.|......|:.|..|
Human   178 YNILNQEQPLAQPASGQPVSLKNISTDTSGYYICTSSNEEGTQFCNITVAVRSP 231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:299845
I-set 56..150 CDD:254352
I-set 157..251 CDD:254352
Ig2_Robo 159..251 CDD:143201
I-set 255..341 CDD:254352 4/17 (24%)
Ig3_Robo 272..341 CDD:143202 4/17 (24%)
IG_like 351..436 CDD:214653 25/110 (23%)
Ig 362..444 CDD:299845 25/107 (23%)
I-set 445..531 CDD:254352 22/96 (23%)
IGc2 459..521 CDD:197706 18/72 (25%)
FN3 549..637 CDD:238020
FN3 673..762 CDD:238020
fn3 770..855 CDD:278470
GPA33NP_005805.1 V-set 26..138 CDD:311561 26/117 (22%)
IGc2 154..218 CDD:197706 18/73 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 267..319
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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