DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and Robo4

DIOPT Version :10

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:NP_001292144.1 Gene:Robo4 / 100911068 RGDID:6494870 Length:1021 Species:Rattus norvegicus


Alignment Length:1442 Identity:275/1442 - (19%)
Similarity:434/1442 - (30%) Gaps:600/1442 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 LLLVLVASNGLPAVRGQYQSPRIIEHPTDLVVKKNEPATLNCKVEGKPEPTIEWFKDGEPVSTNE 100
            |||.::....|.:      .|:|:.||.|.:::.:.||.::|:..|:|.|||.|..:|:|:|...
  Rat    28 LLLFIMGGKALDS------PPQILVHPQDQLLQGSGPAKMSCRASGQPLPTIRWLLNGQPLSMAT 86

  Fly   101 KKSHRVQFKDGALFFYRTMQGKKEQDG--------GEYWCVAKNRVGQAVSRHASLQIAVLRDDF 157
            ...|.:| .||.|..:|.....:.||.        |.|.|.|.||:|.||||.|.|.:|||::||
  Rat    87 PDLHYLQ-SDGTLLLHRPPTHGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDF 150

  Fly   158 RVEPKDTRVAKGETALLECGPPKGIPEPTLIWIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISN 222
            |::|:||....||:.:||||||.|.|:|::.|.|||.||    .:..|.    |.|.|.:|:::.
  Rat   151 RIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPL----VLQPGK----RTVSGDSLMVAR 207

  Fly   223 VEPIDEGNYKCIAQNLVGTRESSYAKLIVQVKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVL 287
            .|..|.|.|.|:|.|..|.|||..|::.:|..|    :.|:.:.|..                  
  Rat   208 AEKNDTGTYMCMATNNAGQRESRAARVSIQESP----DHKEHLELLA------------------ 250

  Fly   288 WKKEEGNIPVSRARILHDEKSLEISNITPTDEGTYVCEAHNNVGQISARASLIVHAPPNFTKRPS 352
                        .||       ::.|:|..:                          |...|.| 
  Rat   251 ------------VRI-------QLENVTLLN--------------------------PEPVKGP- 269

  Fly   353 NKKVGLNGVVQLPCMASGNPPPSVFWTKEGVSTLMFPNSSHGRQHVAADGTLQITDVRQEDEGYY 417
                              .|.|:| |....||                                 
  Rat   270 ------------------KPGPAV-WLSWKVS--------------------------------- 282

  Fly   418 VCSAFSVVDSSTVRVFLQVSSLDERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHDG 482
                                            |||                              
  Rat   283 --------------------------------GPA------------------------------ 285

  Fly   483 HAVQAGNRYSIIQGSSLRVDDLQLSDSGTYTCTASGERGETSWAATLTVEKPGSTSLHRAADPST 547
                                    :.:.:||.....:|.                          
  Rat   286 ------------------------APAQSYTALFRAQRD-------------------------- 300

  Fly   548 YPAPPGTPKVLNVSRTSISLRWAKSQEKPGAVGPIIGYTVEYFSPDLQTGWIVAAQRVGDTQVTI 612
             |...|:|                                          |         |:|.:
  Rat   301 -PRDQGSP------------------------------------------W---------TEVLL 313

  Fly   613 SGLTPGTSYVFLVRAENTQGISVPSGLSNTIKTIEADFDAASANDLSAARTLLTGKSVELIDASA 677
            .||                                                              
  Rat   314 DGL-------------------------------------------------------------- 316

  Fly   678 INASAVRLEWMLHVSADEKYVEGLRIHYKDASVPSAQYHSITVMDASAESFVVGNLKKYTKYEFF 742
            :||.                                                :|.|:....|||.
  Rat   317 LNAK------------------------------------------------LGGLRWGQDYEFK 333

  Fly   743 LTPFFETIEGQPSNSKTALTYEDVPSAPPDNIQIGMYNQTAGWVRWTPPPSQHHNGNLYGYKIEV 807
            :.|......|..||.......|.||||||..:.:...|.:. :|.|.|||:::|||.:.||:: .
  Rat   334 VRPSSGRARGPDSNVLLLRLPEQVPSAPPQEVTLRPGNGSV-FVSWAPPPAENHNGFIRGYQV-W 396

  Fly   808 SAGNTMKVLANMTLNATTTSVLLNNLTTGAVYSVRLNSFTKAGDGPYSKPISLFM---------D 863
            |.||.....||.|:....|.:.:.....|: |.|::.:.|.||.|..|.|:.|.:         |
  Rat   397 SLGNASLPAANWTVVGEQTQLEIAARMPGS-YCVQVAAVTGAGAGEPSIPVCLLLEQAMEQSARD 460

  Fly   864 PTHHVHPPRAHPSGTHDGRHEGQDLTYHNNGNIPPGDINPTTHKKTTDYLSGPWLMVLVCIVLLV 928
            |:.||                                  ..|.::....|..|.::....::|.:
  Rat   461 PSKHV----------------------------------SWTLEQLRATLKRPEVIASGAVLLWL 491

  Fly   929 LVISAAISMVYFKRKHQMTKELGHLSVVSDNEITALNINSKESLWIDHHRGWRTADTDKDSGLSE 993
            |::..|: .:|.:||..:....|.....|::.|....::..:|.|:..  .||:....:|  ||.
  Rat   492 LLLGIAV-CIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLAD--TWRSTSGSRD--LSS 551

  Fly   994 SKLLSHVNSSQSNYNNSDGGTDYAE-VDTRNLTTFYNCRKS-----PDNPTPYATTMIIGTSSSE 1052
            |..||           |..|.|..: :|.|.....::.|..     ||..|.|.:.:...|||..
  Rat   552 SSSLS-----------SRLGVDPRDPLDGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQTSSPP 605

  Fly  1053 TCTKTTSISA----DKDSGTHSPY--SDAFAG--------------------------QVPAVPV 1085
            ......:.:|    .|.:||.||:  ||:...                          |..:.|:
  Rat   606 VRPSPQTPAARRLPPKLTGTSSPWASSDSLCSRRGLCSPRMSLAPAEAWKAKKKQELHQANSSPL 670

  Fly  1086 VKSNYLQYPVEPINW------SEFL---PPPPEHPP---PSSTYGYAQGSPESSRKSSKSAGSGI 1138
            ::.:   :|:|...|      |:.|   |.|....|   |.:...:....|:..|.||:.|...:
  Rat   671 LRGS---HPMEIWAWELGSRASKNLSQSPGPNTCSPREAPGAVVAWRALGPQLHRNSSELAARPL 732

  Fly  1139 -STNQSILNASIHSSSSGGFSAWGVSPQYAVACPPENVYSNPLSAVAGGTQNRYQITPTNQHPPQ 1202
             .|..|:..|..|            .||.......:...|:||.|.        .::..|...|.
  Rat   733 PPTPLSLRGAPSH------------DPQSQCVEKLQAPSSDPLPAA--------PLSVLNSSRPS 777

  Fly  1203 LP--AYFATTGPGGAVPPNHLPFATQRHAASEYQAGL----NAARCAQSRACNSCDALATP-SPM 1260
            .|  ::.:...||.    ::|..::......|.|..:    ..|.|.:     ..|...|| :.:
  Rat   778 SPQASFLSVPSPGS----SNLSSSSLSSLEEEDQDSVLTPEEVALCLE-----LSDGEETPTNSV 833

  Fly  1261 QPPPPVPVPEGWYQPVHPNSHPMHPTSSNHQIYQCSSECSDHSRSSQSHKRQL------------ 1313
            .|.|..|.|...|      .:...||||.         .:|..|:......::            
  Rat   834 SPMPRAPSPPATY------GYISIPTSSG---------LADMGRAGGGVGSEVGNLLCPPRLCPT 883

  Fly  1314 QLEEHGSSAKQRGGHHRRRAPVVQPCMESENE-NMLAEYEQRQYTSDCCNSSREGDTCSCSEGSC 1377
            .....||.|...|.......|..:..:.|.:: :.||:....:..:...:|.  |.:....|..|
  Rat   884 PTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADAHFARALAVAVDSF--GFSLEPREADC 946

  Fly  1378 LYAEAGE-PAPR 1388
            ::.:|.. |:||
  Rat   947 VFTDASSPPSPR 958

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:472250 38/102 (37%)
Ig strand B 73..77 CDD:409353 1/3 (33%)
Ig strand C 86..90 CDD:409353 2/3 (67%)
Ig strand E 111..115 CDD:409353 2/3 (67%)
Ig strand F 129..134 CDD:409353 2/4 (50%)
Ig strand G 143..146 CDD:409353 2/2 (100%)
IgI_2_Robo 158..251 CDD:409389 38/92 (41%)
Ig strand A 158..161 CDD:409389 1/2 (50%)
Ig strand A' 163..167 CDD:409389 2/3 (67%)
Ig strand B 171..178 CDD:409389 3/6 (50%)
Ig strand C 186..191 CDD:409389 1/4 (25%)
Ig strand C' 193..196 CDD:409389 1/2 (50%)
Ig strand D 209..213 CDD:409389 1/3 (33%)
Ig strand E 216..222 CDD:409389 1/5 (20%)
Ig strand F 229..237 CDD:409389 4/7 (57%)
Ig strand G 240..251 CDD:409389 5/10 (50%)
IgI_3_Robo 258..341 CDD:409390 6/82 (7%)
Ig strand A 258..261 CDD:409390 0/2 (0%)
Ig strand A' 263..267 CDD:409390 0/3 (0%)
Ig strand B 270..279 CDD:409390 0/8 (0%)
Ig strand C 285..290 CDD:409390 0/4 (0%)
Ig strand C' 293..296 CDD:409390 0/2 (0%)
Ig strand D 299..304 CDD:409390 2/4 (50%)
Ig strand E 305..313 CDD:409390 0/7 (0%)
Ig strand F 320..328 CDD:409390 0/7 (0%)
Ig strand G 331..341 CDD:409390 0/9 (0%)
Ig 346..437 CDD:472250 8/90 (9%)
Ig strand B 362..366 CDD:409353 0/3 (0%)
Ig strand C 375..379 CDD:409353 1/3 (33%)
Ig strand E 402..406 CDD:409353 0/3 (0%)
Ig strand F 416..421 CDD:409353 0/4 (0%)
Ig strand G 429..432 CDD:409353 0/2 (0%)
Ig 446..531 CDD:472250 6/84 (7%)
Ig strand B 462..466 CDD:409544 0/3 (0%)
Ig strand C 475..479 CDD:409544 0/3 (0%)
Ig strand E 497..501 CDD:409544 0/3 (0%)
FN3 507..>916 CDD:442628 63/417 (15%)
Ig strand F 511..516 CDD:409544 2/4 (50%)
Ig strand G 524..527 CDD:409544 0/2 (0%)
FN3 549..637 CDD:238020 8/87 (9%)
fn3 770..855 CDD:394996 27/84 (32%)
Robo4NP_001292144.1 Ig 42..144 CDD:472250 38/102 (37%)
Ig strand B 59..63 CDD:409490 1/3 (33%)
Ig strand C 72..76 CDD:409490 2/3 (67%)
Ig strand E 96..100 CDD:409490 2/3 (67%)
Ig strand F 122..127 CDD:409490 2/4 (50%)
Ig strand G 136..139 CDD:409490 2/2 (100%)
Ig 151..236 CDD:472250 38/92 (41%)
Ig strand B 165..169 CDD:409389 1/3 (33%)
Ig strand C 179..183 CDD:409389 0/3 (0%)
Ig strand E 201..205 CDD:409389 1/3 (33%)
Ig strand F 215..220 CDD:409389 2/4 (50%)
Ig strand G 229..232 CDD:409389 1/2 (50%)
fn3 361..443 CDD:394996 27/84 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 544..563 8/31 (26%)
PHA03247 <578..861 CDD:223021 65/329 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..634 10/33 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 726..810 19/107 (18%)

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