DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and igsf10

DIOPT Version :10

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:XP_012819117.2 Gene:igsf10 / 100494018 XenbaseID:XB-GENE-6072998 Length:2884 Species:Xenopus tropicalis


Alignment Length:813 Identity:182/813 - (22%)
Similarity:314/813 - (38%) Gaps:182/813 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 HPENHA-----------------IARSTSTTNNPSRSRSSRMWLLPAWLLLVLVASNGLPAVRGQ 52
            |.||:|                 :..:|:|.:....:::||                        
 Frog  1862 HSENNAPSLAPQQHGKKTGLEKPVTMTTTTVSTSFSTQNSR------------------------ 1902

  Fly    53 YQSPRII-EHPTDLVVKKNEPATLNCKVEGKPEPTIEWFK--DGEPVSTNEKKSHRVQFKDGALF 114
             ..|||| .......|..|..|.:.|:..|.|.|||.|.|  .|..||...:.:....|.:|.| 
 Frog  1903 -SKPRIIGGKAASFTVLANSDAFIPCEASGNPSPTILWTKVSSGTFVSKTRRVNKMEVFMNGTL- 1965

  Fly   115 FYRTMQGKKEQDGGEYWCVAKNRVGQAVSRHASLQIAVLRDDFRV---EPKDTRVAKGETALLEC 176
               ::.....||||:|.|||.|::|   |....:.::|:....|:   ..::..|..|.:..:.|
 Frog  1966 ---SIPSVGIQDGGQYLCVANNQLG---SDRLLVTLSVITYPPRILQGRSREITVHSGNSVNVNC 2024

  Fly   177 GPPKGIPEPTLIW-IKDGVPLDDLKAMSFGASS---RVRIVDGGNLLISNVEPIDEGNYKCIAQN 237
             ..:|.|.||:.| :|:       :.:.||.|:   ::.:...|.|:|.:|...|.|.|:|:|.|
 Frog  2025 -QAEGSPFPTITWTLKN-------ETIPFGTSTSNRKIFVQPDGTLIIKDVTVYDRGIYRCLATN 2081

  Fly   238 LVGTRESSYAKLIVQVKPYFMKEPKDQVML-YGQTATFHCSVGGDPPPKVLWKKEEGN----IPV 297
            |.|....:....::...|..::|.:..|:. .|:.....|:..|:|.|.|.|...:|.    :..
 Frog  2082 LAGEDTFTVRIQVIAAPPVIVEEKRQTVLAGPGENLKIPCTAKGNPQPTVHWVAFDGTKIKPLQY 2146

  Fly   298 SRARI-LHDEKSLEISNITPTDEGTYVCEAHNNVGQISARASLIVHAPPNFTK----RPSNKKVG 357
            ..|:: |....:|.|.|:..||.|.|.|.|.::.|......:|||.....|.|    .|...::.
 Frog  2147 VNAKLFLFSNGTLYIRNVASTDRGNYECIATSSTGSERRVVNLIVEQSDTFPKITDASPKATEMN 2211

  Fly   358 LNGVVQLPCMASGNPPPSVFW---TKEGVSTL--------MFPNSSHGRQHVAADGTLQITDVRQ 411
            ....:.|.|.|:|.|.|.:.|   :|..|..|        :|||           |||.:..|..
 Frog  2212 FGDKLMLNCTATGEPKPRIIWRLPSKAVVDQLHRMGSRIQVFPN-----------GTLFVDSVND 2265

  Fly   412 EDEGYYVCSAFSVVDSSTVRVFLQVSSLDERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRI 476
            :|.|.|:|.|.:.:...   |.|...|:..:|..|||..|..:.:|.|....:.|:|:|:|.|.|
 Frog  2266 KDAGDYLCVARNKMGDD---VILMKVSVTMKPAKIIQKQPLAKQVPYGKDFKVDCKASGSPLPDI 2327

  Fly   477 KW-FHDG----HAVQAGN------RYSIIQGSSLRVDDLQLSDSGTYTCTASGERGETSWAATLT 530
            .| ..||    :.:||.:      ||.:....:|.::.:.:::.|.|||.|..:.|.......:|
 Frog  2328 SWSLPDGTMINNILQADDSGRRKRRYILFDNGTLYLNKVGIAEEGDYTCYAENQLGRDEMKVHIT 2392

  Fly   531 VEKPGSTSLHRAADPSTYPAPPGTPKVLNVSRTSISLRWAKSQEKPGAVGPIIGYTVEYFSPDLQ 595
            |..  :..|.:....:.|.|..|...:|:..        |..:.||                  :
 Frog  2393 VVT--AAPLIKLNMKTRYAAMAGESVILDCE--------ANGEPKP------------------K 2429

  Fly   596 TGWIVAAQRV-------------GDTQVTISGLTPGTSYVFLVRAENTQGISVPSGLSNTIKTIE 647
            ..|::.:..:             |...|:...|.....|:.:.|.        |:|....:..:|
 Frog  2430 IFWLLPSSDMIAISHDRYLLHENGSLTVSQVKLLDAGEYMCVARN--------PAGDDTKLLRLE 2486

  Fly   648 ADFDAASANDLSAARTLLTGKSV----ELIDASAINASAVRLEWMLHVSADEKYVEGLRIHYKDA 708
            ........|.|.:.::::...::    :|||..|..|:.:::.|::   .|..|:          
 Frog  2487 VHPKPPIINGLYSNKSIIKDTAIKHSRKLIDCKAEGAAPLQVMWIM---PDNIYL---------- 2538

  Fly   709 SVPSAQYHSITVMDASAESFVVGNLKKYTKYEF 741
               :|.||...::.....:..:.|::.....||
 Frog  2539 ---TAPYHGSRILVHQNGTLEIRNIRPSDTAEF 2568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:472250 32/97 (33%)
Ig strand B 73..77 CDD:409353 1/3 (33%)
Ig strand C 86..90 CDD:409353 2/3 (67%)
Ig strand E 111..115 CDD:409353 2/3 (67%)
Ig strand F 129..134 CDD:409353 2/4 (50%)
Ig strand G 143..146 CDD:409353 1/2 (50%)
IgI_2_Robo 158..251 CDD:409389 25/99 (25%)
Ig strand A 158..161 CDD:409389 1/5 (20%)
Ig strand A' 163..167 CDD:409389 0/3 (0%)
Ig strand B 171..178 CDD:409389 1/6 (17%)
Ig strand C 186..191 CDD:409389 2/5 (40%)
Ig strand C' 193..196 CDD:409389 0/2 (0%)
Ig strand D 209..213 CDD:409389 0/3 (0%)
Ig strand E 216..222 CDD:409389 3/5 (60%)
Ig strand F 229..237 CDD:409389 4/7 (57%)
Ig strand G 240..251 CDD:409389 1/10 (10%)
IgI_3_Robo 258..341 CDD:409390 23/88 (26%)
Ig strand A 258..261 CDD:409390 0/2 (0%)
Ig strand A' 263..267 CDD:409390 1/3 (33%)
Ig strand B 270..279 CDD:409390 1/8 (13%)
Ig strand C 285..290 CDD:409390 2/4 (50%)
Ig strand C' 293..296 CDD:409390 1/6 (17%)
Ig strand D 299..304 CDD:409390 1/5 (20%)
Ig strand E 305..313 CDD:409390 2/7 (29%)
Ig strand F 320..328 CDD:409390 4/7 (57%)
Ig strand G 331..341 CDD:409390 2/9 (22%)
Ig 346..437 CDD:472250 27/105 (26%)
Ig strand B 362..366 CDD:409353 1/3 (33%)
Ig strand C 375..379 CDD:409353 1/6 (17%)
Ig strand E 402..406 CDD:409353 3/3 (100%)
Ig strand F 416..421 CDD:409353 2/4 (50%)
Ig strand G 429..432 CDD:409353 0/2 (0%)
Ig 446..531 CDD:472250 26/95 (27%)
Ig strand B 462..466 CDD:409544 0/3 (0%)
Ig strand C 475..479 CDD:409544 2/4 (50%)
Ig strand E 497..501 CDD:409544 1/3 (33%)
FN3 507..>916 CDD:442628 41/252 (16%)
Ig strand F 511..516 CDD:409544 3/4 (75%)
Ig strand G 524..527 CDD:409544 0/2 (0%)
FN3 549..637 CDD:238020 12/100 (12%)
fn3 770..855 CDD:394996
igsf10XP_012819117.2 leucine-rich repeat 40..59 CDD:275380
LRR <59..>220 CDD:443914
leucine-rich repeat 60..83 CDD:275380
leucine-rich repeat 84..107 CDD:275380
leucine-rich repeat 108..131 CDD:275380
leucine-rich repeat 132..155 CDD:275380
leucine-rich repeat 156..187 CDD:275380
leucine-rich repeat 188..211 CDD:275380
PCC 193..>277 CDD:188093
Ig 477..552 CDD:472250
Ig strand B 490..494 CDD:409353
Ig strand C 503..508 CDD:409353
Ig strand E 531..535 CDD:409353
Ig strand F 545..550 CDD:409353
Ig <590..649 CDD:472250
Ig strand C 601..605 CDD:409353
Ig strand E 625..629 CDD:409353
Ig strand F 639..644 CDD:409353
Herpes_BLLF1 <885..1272 CDD:282904
Ig_3 1904..1984 CDD:464046 29/83 (35%)
Ig 2004..2094 CDD:472250 24/97 (25%)
Ig strand B 2020..2024 CDD:409353 0/3 (0%)
Ig strand C 2033..2037 CDD:409353 1/3 (33%)
Ig strand E 2060..2064 CDD:409353 2/3 (67%)
Ig strand F 2074..2079 CDD:409353 2/4 (50%)
Ig strand G 2087..2090 CDD:409353 0/2 (0%)
Ig_3 2098..2177 CDD:464046 21/78 (27%)
Ig_3 2198..2277 CDD:464046 24/89 (27%)
Ig 2300..2383 CDD:472250 22/82 (27%)
Ig strand C 2326..2330 CDD:409353 1/3 (33%)
Ig strand E 2359..2363 CDD:409353 1/3 (33%)
Ig strand F 2373..2378 CDD:409353 3/4 (75%)
IG_like 2410..2487 CDD:214653 14/110 (13%)
Ig strand B 2416..2420 CDD:409353 1/3 (33%)
Ig strand C 2429..2433 CDD:409353 0/3 (0%)
Ig strand E 2453..2457 CDD:409353 1/3 (33%)
Ig strand F 2467..2472 CDD:409353 1/4 (25%)
Ig strand B 2515..2518 CDD:409353 2/2 (100%)
IG_like 2516..2587 CDD:214653 13/69 (19%)
Ig strand C 2527..2531 CDD:409353 0/3 (0%)
Ig strand E 2553..2557 CDD:409353 0/3 (0%)
Ig strand F 2567..2572 CDD:409353 2/2 (100%)
Ig strand G 2580..2583 CDD:409353
Ig_3 2605..2672 CDD:464046
Ig_3 2688..2767 CDD:464046
Ig_3 2784..2866 CDD:464046
Blue background indicates that the domain is not in the aligned region.

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