DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and robo2

DIOPT Version :9

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:XP_031752453.1 Gene:robo2 / 100493913 XenbaseID:XB-GENE-980527 Length:1620 Species:Xenopus tropicalis


Alignment Length:1404 Identity:442/1404 - (31%)
Similarity:657/1404 - (46%) Gaps:258/1404 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 MWLL----------PAWLLLVLVASNG-----LPAVRGQYQS-----------PRIIEHPTDLVV 67
            :|::          |.:||::::..:|     :...:|::..           |||:|||:|::|
 Frog     3 IWIMLSSLRQRAASPEFLLILMLFVSGVTQSKISRTKGKHWKGGSRLRQEDFPPRIVEHPSDVIV 67

  Fly    68 KKNEPATLNCKVEGKPEPTIEWFKDGEPVST--NEKKSHRVQFKDGALFFYRTMQGKK-EQDGGE 129
            .|.||.|||||.||:|.|||||:||.|.|.|  ::.:|||:....|:|||.|.:.|:| :.|.|.
 Frog    68 SKGEPTTLNCKAEGRPTPTIEWYKDLERVETDKDDPRSHRMLLPSGSLFFLRIIHGRKFKPDEGS 132

  Fly   130 YWCVAKNRVGQAVSRHASLQIAVLRDDFRVEPKDTRVAKGETALLECGPPKGIPEPTLIWIKDGV 194
            |.|||:|.:|:|:||:|||::|:||||||:.|.|..||.||.|:|||.||:|.||||:.|.||.|
 Frog   133 YVCVARNYLGEAMSRNASLEVALLRDDFRLNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKV 197

  Fly   195 PLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSYAKLIVQVKPYFMK 259
            .:||       ...|:.| .||.|::||....|.|.|.|:..|:||.|:|..|:|.|..:|.|::
 Frog   198 RIDD-------KDERISI-RGGKLMLSNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLR 254

  Fly   260 EPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARILHDEKSLEISNITPTDEGTYVC 324
            .|.:||:|..:...|.|.|.|||.|.|.|||::.::|..|..| .|:.:|.|...:.:||||:.|
 Frog   255 RPINQVVLEDEAVEFRCQVQGDPQPTVRWKKDDVDLPRGRYDI-KDDYTLRIKKASSSDEGTFAC 318

  Fly   325 EAHNNVGQISARASLIVH----APPNFTKRPSNKKVGLNGVVQLPCMASGNPPPSVFWTKEGVST 385
            .:.|.||:|.|.|:|.|.    |||.|..||.::.|.....|...|.|.|||.|:|||.|||...
 Frog   319 ISENRVGKIEASATLTVRVRPVAPPQFVIRPRDQIVAQGRTVTFGCEAKGNPQPAVFWQKEGSQN 383

  Fly   386 LMFPN---SSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQVSS-LDERPPPI 446
            |:|||   ..:.|..|:..|.|.||.:::.|.|||:|.|.:|..|...:..|:|:. |.:|||||
 Frog   384 LLFPNQPLQPNSRYSVSPTGDLTITSIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPI 448

  Fly   447 IQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHDGHAVQAGN--RYSIIQGSSLRVDDLQLSDS 509
            |..|||||||.....|.|.|:.||:|.|.|.|..:|.....|.  |.||:...:|::..|:::||
 Frog   449 ILQGPANQTLAVDGTAVLKCKTTGDPMPVISWLKEGFKGFIGRDARLSILDQGTLQIKGLKVTDS 513

  Fly   510 GTYTCTASGERGETSWAATLTVEKPGSTSLHRAADPSTYPAPPGTPKVLNVSRTSISLRWAKSQE 574
            |||||.|:...|||:|:|.|.|.:.|...:.:..|.:..|..|..|:|.:||:.|::|.|     
 Frog   514 GTYTCVATSSSGETTWSAVLEVTESGGAIISKNYDLNDLPGSPSKPQVTDVSKNSVTLSW----- 573

  Fly   575 KPGAVG--PIIGYTVEYFSPDLQTGWIVAAQRVGDTQVTISGLTPGTSYVFLVRAENTQGISVPS 637
            :||:.|  |:..|.:|.||..:...|...|..|..|..|:.||.|.|.|:|:|||.||:|:|.||
 Frog   574 QPGSPGILPVTSYIIEAFSQSVSNSWQTVANHVKTTLYTVKGLRPNTIYLFMVRAINTEGLSDPS 638

  Fly   638 GLSNTIKTIEADFDAASANDLSAARTLLTGKSVELIDASAINASAVRLEWMLHVSADEKYVEGLR 702
            .:|:.::|.:.. ......|....:..|....|.|.:...:..:.:::.||  |....::::|.|
 Frog   639 PISDPVRTQDIS-PPVQGVDHRQVQKELGDVIVRLHNPVVLTPTTIQVTWM--VDRQSQFIQGYR 700

  Fly   703 IHYKDAS---VPSAQYHSITVMDASAESFVVGNLKKYTKYEFFLTPFFETIEGQPSNSKTALTYE 764
            :.|:..|   .||| :.|:.|...:..|.|:.||||...||..:.|:|...:|..|.||:|.|.|
 Frog   701 VMYRQTSGLQTPSA-WQSLEVKVPAERSAVLTNLKKGITYEIKVRPYFNEFQGMDSESKSARTTE 764

  Fly   765 DVPSAPPDNI---QIGMYNQTAGWVRWTPPPSQHHNGNLYGYKIEVSAGNTMKVLANMTLNATTT 826
            :.|||||.::   .:|..|.|:..:.|.||||.|.||.:..|:| ...||..:...|.|::|...
 Frog   765 EAPSAPPQSVTVMTVGNNNSTSISISWDPPPSDHQNGIIQDYRI-WCLGNETRFHINKTVDAAIR 828

  Fly   827 SVLLNNLTTGAVYSVRLNSFTKAGDGPYSKPISLFMDPTHHVHPPRAHPSGTHDGRHEGQDLTYH 891
            ||::..|..|..|.|.:.:.|.||.|..|.|                            |.:...
 Frog   829 SVVIGGLFPGIQYRVEVAASTSAGTGVKSAP----------------------------QHIQIG 865

  Fly   892 NNGNIPPGDINPTTHKKTTDYLSGPWLMVLVCIVLLVLVISAAISMVYFKRKHQMTKELGHLSVV 956
            |...:...:.|.:..::.||.:..|..:..:.....|:::..:| .:|::||.:  |.|.:.:|.
 Frog   866 NRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSI-WLYWRRKKR--KGLSNYAVQ 927

  Fly   957 S------DNEITALN----INSKESLW---IDHHRGWRTADTDKDSGL-SESKLLSHVNSSQSNY 1007
            |      |:..|.::    :.:|:..|   :...||        |.|| |.......:|::..:|
 Frog   928 SFTFTPADSPDTTMHHKVALGTKKGSWHKTVTFQRG--------DGGLMSNGSRPGLLNANDPSY 984

  Fly  1008 --------------NNSDGGTD------------------------------YAEVDTRNLTTFY 1028
                          |||:.|.:                              |:.:|....:: |
 Frog   985 PWLADSWPASSMPVNNSNNGPNDLVNFSCGDVLPTVPGQGEKTATMLSDGAIYSSIDFTTKSS-Y 1048

  Fly  1029 NCRKSPDNPTPYATTMIIGTSSSETCTK-------TTSISADKD-SGTHSPYSDAFAGQVPAVPV 1085
            ||.......||||||.|:.::|......       .:||....| :|.....:|...|       
 Frog  1049 NCPGQIAQTTPYATTQILHSNSIHELAVDLPDPQWKSSIQQKSDLTGLGYCLTDQGKG------- 1106

  Fly  1086 VKSNYLQYPVE-----------PINWSEFLPPPPEHPPPSSTYGYAQGSPESSRKSSKSAGSGIS 1139
              ||.|.|..:           |.|.|:.......| ..|...|...|..:..||.:|       
 Frog  1107 --SNALLYIPDYRMAEGLSNRIPHNQSQDFSTTSSH-NSSERSGSLSGGKDGKRKKNK------- 1161

  Fly  1140 TNQSILNASIHSSSSGGFSAWGVSPQYAVACPPENVYSNPLSAVAGGTQNRYQITPTNQHPPQLP 1204
                  |:|..|.::|  |:|...|     .||.     |:..:.|.....|.:    :|  |..
 Frog  1162 ------NSSKISKNNG--SSWANVP-----LPPP-----PIQPLPGTEIEHYGL----EH--QET 1202

  Fly  1205 AYFATTGPGGAVPPNHLPFATQRHAASEYQAGLNAAR--------CAQSRACN---SCDALATPS 1258
            .|    ...|..||  ||..|..|..|:.:...:..|        .|.|.|.:   ...|..|||
 Frog  1203 GY----DTNGWCPP--LPVQTYLHQGSDDELEEDEERVPTPPVRGVASSPAISFGQQSTATLTPS 1261

  Fly  1259 P---MQPPPPVPVPE------------GWYQPVHPNSHP 1282
            |   |||.....:.|            .|:  :|.|:.|
 Frog  1262 PREEMQPMLQAHLDELTRAYQFDIAKQSWH--LHSNNQP 1298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:299845 53/97 (55%)
I-set 56..150 CDD:254352 53/96 (55%)
I-set 157..251 CDD:254352 43/93 (46%)
Ig2_Robo 159..251 CDD:143201 41/91 (45%)
I-set 255..341 CDD:254352 35/85 (41%)
Ig3_Robo 272..341 CDD:143202 29/68 (43%)
IG_like 351..436 CDD:214653 34/87 (39%)
Ig 362..444 CDD:299845 35/85 (41%)
I-set 445..531 CDD:254352 40/87 (46%)
IGc2 459..521 CDD:197706 24/63 (38%)
FN3 549..637 CDD:238020 35/89 (39%)
FN3 673..762 CDD:238020 27/91 (30%)
fn3 770..855 CDD:278470 30/87 (34%)
robo2XP_031752453.1 IgC_1_Robo 56..154 CDD:409490 53/97 (55%)
Ig strand B 73..77 CDD:409490 2/3 (67%)
Ig strand C 86..90 CDD:409490 3/3 (100%)
Ig strand E 113..117 CDD:409490 2/3 (67%)
Ig strand F 132..137 CDD:409490 2/4 (50%)
Ig strand G 146..149 CDD:409490 2/2 (100%)
Ig 161..246 CDD:416386 42/92 (46%)
Ig strand A 161..164 CDD:409353 1/2 (50%)
Ig strand A' 166..170 CDD:409353 1/3 (33%)
Ig strand B 174..181 CDD:409353 4/6 (67%)
Ig strand C 189..194 CDD:409353 2/4 (50%)
Ig strand C' 196..199 CDD:409353 1/2 (50%)
Ig strand D 205..209 CDD:409353 2/4 (50%)
Ig strand E 211..217 CDD:409353 2/5 (40%)
Ig strand F 224..232 CDD:409353 3/7 (43%)
Ig strand G 235..246 CDD:409353 5/10 (50%)
Ig 253..335 CDD:416386 33/82 (40%)
Ig strand A 253..256 CDD:409353 0/2 (0%)
Ig strand A' 258..262 CDD:409353 2/3 (67%)
Ig strand B 265..274 CDD:409353 2/8 (25%)
Ig strand C 280..285 CDD:409353 2/4 (50%)
Ig strand C' 288..291 CDD:409353 0/2 (0%)
Ig strand D 294..299 CDD:409353 2/5 (40%)
Ig strand E 300..307 CDD:409353 2/6 (33%)
Ig strand F 314..322 CDD:409353 3/7 (43%)
Ig strand G 325..335 CDD:409353 5/9 (56%)
IgI_4_Robo 344..441 CDD:409391 37/96 (39%)
Ig strand B 360..364 CDD:409391 1/3 (33%)
Ig strand C 373..377 CDD:409391 2/3 (67%)
Ig strand E 403..407 CDD:409391 2/3 (67%)
Ig strand F 417..422 CDD:409391 3/4 (75%)
Ig strand G 430..433 CDD:409391 0/2 (0%)
IgI_5_Robo 448..535 CDD:409544 39/86 (45%)
Ig strand B 464..468 CDD:409544 2/3 (67%)
Ig strand C 477..481 CDD:409544 1/3 (33%)
Ig strand E 501..505 CDD:409544 1/3 (33%)
Ig strand F 515..520 CDD:409544 4/4 (100%)
Ig strand G 528..531 CDD:409544 1/2 (50%)
FN3 553..646 CDD:238020 38/97 (39%)
FN3 677..762 CDD:238020 27/87 (31%)
FN3 771..863 CDD:238020 32/120 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 103 1.000 Domainoid score I6691
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H43188
Inparanoid 1 1.050 602 1.000 Inparanoid score I932
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 1 1.000 - - mtm9461
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X493
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
66.050

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