DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and robo3

DIOPT Version :9

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:XP_002937567.3 Gene:robo3 / 100493553 XenbaseID:XB-GENE-1032334 Length:1424 Species:Xenopus tropicalis


Alignment Length:1493 Identity:448/1493 - (30%)
Similarity:680/1493 - (45%) Gaps:298/1493 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 PRIIEHPTDLVVKKNEPATLNCKVEGKPEPTIEWFKDGEPVST--NEKKSHRVQFKDGALFFYRT 118
            |||:|||:|.:|.|.||||||||.||:|.|.|||:||||.|.|  ::.:|||:....|:|||.|.
 Frog    65 PRIVEHPSDHIVSKGEPATLNCKAEGRPTPIIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 129

  Fly   119 MQGKKEQ-DGGEYWCVAKNRVGQAVSRHASLQIAVLRDDFRVEPKDTRVAKGETALLECGPPKGI 182
            :.|::.: |.|.|.|||:|.:|::|||:|||::|:||||||..|.|..||.||.|::||.||:|.
 Frog   130 VHGRRSKPDEGVYICVARNYLGESVSRNASLEVAILRDDFRQAPNDVVVAAGEPAVMECIPPRGH 194

  Fly   183 PEPTLIWIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSYA 247
            ||||:.|.||.:.:.|       ...|:.| .||.|:|||....|.|.|.|:|.|:||.|:|..|
 Frog   195 PEPTISWKKDNMRISD-------KDERITI-RGGKLMISNTRKSDAGMYICVATNMVGERDSEPA 251

  Fly   248 KLIVQVKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARILHDEKSLEIS 312
            :|:|..:|.|::.|.:||:|......|:|.|.|||.|...|:||||.:|..|..||:| .:|.||
 Frog   252 QLVVFERPTFIRRPINQVVLADDMVDFNCEVQGDPVPTARWRKEEGELPRGRYEILND-NTLRIS 315

  Fly   313 NITPTDEGTYVCEAHNNVGQISARASLIVHA----PPNFTKRPSNKKVGLNGVVQLPCMASGNPP 373
            .::..|||||.|...|:||:..|..||.||.    ||....||.::.|.....|...|...||||
 Frog   316 RVSAEDEGTYTCITENSVGKSEASGSLGVHVGPFFPPQLVTRPRDQIVVQGRTVTFQCETKGNPP 380

  Fly   374 PSVFWTKEGVSTLMFPN---SSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQ 435
            |:|||.|||...|:||:   .:.||..|:..|.|.|.||:..|.|||:|.|.||..|...:..|:
 Frog   381 PAVFWQKEGSQILLFPSQPPQTVGRFSVSPSGELTIIDVQTGDSGYYMCQAISVAGSILAKALLE 445

  Fly   436 V-SSLDERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHDGHAVQAGN-RYSIIQGSS 498
            | .:..:|.||||:.|||||||...|...:.|:.:|||.|.|.|..||..:...: |..::...:
 Frog   446 VEDATSDRIPPIIRRGPANQTLAVDSTVQMHCQVSGNPLPSIHWLKDGQRIVGSDPRIGVLDSGN 510

  Fly   499 LRVDDLQLSDSGTYTCTASGERGETSWAATLTVEKPGSTSLHRAADPSTYPAPPGTPKVLNVSRT 563
            |::..||::|||.|||.|:...|||:|:..:.|::.||....:.::||..|..|..|.|.:|::.
 Frog   511 LQITHLQVTDSGVYTCVATSSTGETTWSGFVEVQEKGSPIHVQLSEPSLVPGSPSKPLVTDVTKN 575

  Fly   564 SISLRWAKSQEKPGAVGPIIGYTVEYFSPDLQTGWIVAAQRVGDTQVTISGLTPGTSYVFLVRAE 628
            |::|.|..:.:....  .:..|.:|.||....:.|...|..|...:.|:.||.|.|.|:|::||.
 Frog   576 SVTLTWQPNLQAGNT--QVNSYIIEAFSQSAGSTWQTVADNVKVEKHTVVGLNPNTIYLFIIRAV 638

  Fly   629 NTQGISVPSGLSNTIKTIEADFDAASANDLSAARTLLTGK-SVELIDASAINASAVRLEWMLHVS 692
            |:.|:|.||.:|..::|.:........:.....|.|  |: .|:|.....:.:|.|::.|.  |.
 Frog   639 NSYGLSDPSPISEPVRTQDVSPTRQGVDHRQVQRQL--GEVVVQLQQPIILTSSTVQVTWT--VD 699

  Fly   693 ADEKYVEGLRIHYK-DASVPSAQYHSITVMDASAESFVVGNLKKYTKYEFFLTPFFETIEGQPSN 756
            ...::::|.|:.|: .:||...|    .|...|..:.::.:|||.|:||..:.|:|:..:|..|:
 Frog   700 RQAQFIQGYRVMYRPKSSVWLVQ----DVKSPSERNTILVDLKKGTEYEIKIRPYFDEFQGMDSD 760

  Fly   757 SKTALTYEDVPSAPPDNIQI---GMYNQTAGWVRWTPPPSQHHNGNLYGYKIEVSAGNTMKVLAN 818
            .....|.|:||||||..:.:   |..|.|...:.|.||..:|.||.:..|:|.| .||..:...|
 Frog   761 VLLIRTPEEVPSAPPQAVSVVTLGTNNSTNISISWEPPIVEHQNGIIQDYRIWV-LGNETRYHIN 824

  Fly   819 MTLNATTTSVLLNNLTTGAVYSVRLNSFTKAGDGPYSKPISLFMDPTHHVHPPRAHPSGTHDGRH 883
            .|::.|..|.::..|:.|.:|.|.:.:.|.||.|..|:||::.:.|:....|             
 Frog   825 RTVDGTVHSTVIRGLSPGVLYHVEVAAATSAGFGVKSQPITIQIKPSSDQVP------------- 876

  Fly   884 EGQDLTYHNNGNIPPGDINPTTHKKTTDYLSGP----------WLMVLVCIVLLVLVISAAISMV 938
                        :..|: |.:..::.||.:..|          | ::|:|..:          .:
 Frog   877 ------------VASGE-NVSLTEQITDVVKQPAFIAGIGGACW-VILMCFSV----------WI 917

  Fly   939 YFKRKHQMTKELGHLSV-----------VSDNEITA----LNINSKESLWIDHHRGWRTADTDKD 988
            |.:||.:  |||.|.:.           .|...|||    |..::....|:..  .|...:..::
 Frog   918 YCRRKKR--KELSHYTASFAYTPAVSFPESSGHITARPGMLATSASNYPWLAD--SWPATNLLRN 978

  Fly   989 SGLSE---SKLLSHVNSSQSNYNN-----------------SDGGTDYAEVD--TRNLTTFYNCR 1031
            ....|   :....:.|.|:..||:                 |||.. |:.:|  |.::.||... 
 Frog   979 GKPKEPAGNCCPGNHNPSERYYNDAGISNYIAQTEKFGTGVSDGPI-YSTIDPTTDDMRTFNGA- 1041

  Fly  1032 KSPDNPTPYATTMII-----GTSSSETCTKTTSISA----------DKDSGTHSPYSDAFAGQVP 1081
             ...:.||||||.::     ...|.|......::.|          |:....:.|.|.       
 Frog  1042 -FSQHTTPYATTPVVPYGGQNMHSPELEENQWNVQAGTSGVLYAQPDRTKAENGPKSG------- 1098

  Fly  1082 AVPVVKSNYLQYPVE--PINWSEFLPPPPEHPPPSSTYGYAQGSPESSRKSSKSAGSGISTNQSI 1144
                 |...:..||:  .:||:|.||||   ||.:....|.:...:....|...........::.
 Frog  1099 -----KQKAIGKPVKTPSLNWTEILPPP---PPANELSQYQEEDTDVEMSSDTEEWCPPLPERTY 1155

  Fly  1145 LNASIHSSSSGGFSAWGVSPQYAVAC---PPENVYSNPLSAVAGGTQNRYQITPTNQ-------- 1198
            |..:|..                 .|   ||....|:|  |.:.|.|:...:||:.|        
 Frog  1156 LMENIQE-----------------GCPLPPPRGEASSP--AHSYGQQSTATLTPSPQDEMHAAED 1201

  Fly  1199 -----------HPPQLPAYFATTGPGGAVP----PNHLPFATQR----HAASEYQAGLNAARCAQ 1244
                       ||.:||:        |:||    |:  |..||.    |.|:|   |..|.|...
 Frog  1202 IPRLHQFEIPPHPRRLPS--------GSVPIPRAPS--PPLTQSNPSLHTATE---GAEAQRQGH 1253

  Fly  1245 SRACNS-------------------CDALATPSPMQ----------------------PPPPVPV 1268
            .|..:.                   .:.::|| |.|                      ||||.|.
 Frog  1254 RRNLSQNPNLSAENVNLPNSGKSQLGENISTP-PGQKSRAKKKSKSGHYRREAKQGDLPPPPEPP 1317

  Fly  1269 PEGWYQPVHPNSHPMHPTSSNHQIYQCSSECSDHSRSSQS-HKRQLQLEEHGSSAKQRGGHHRR- 1331
            |.. .:|..|:::.:.        .:||:...:...|:.| .:|...|::.|::..|   .|:| 
 Frog  1318 PAD-EEPCSPHTNGLR--------MECSASSLERDTSTSSVERRNGVLQQRGAAGPQ---FHQRD 1370

  Fly  1332 ---RAPVVQPCMESENENMLAEYEQRQYTSDCCNSSREGDTCSCSEGSCLYAEAGEPAPRQMT 1391
               ..|..:|       |.|:   :.|.:|:|..:.     .|.|.||.  ...|:.:.|..|
 Frog  1371 DEELIPYSKP-------NFLS---RSQMSSNCSTTG-----SSSSRGSA--GSRGQASGRSKT 1416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:299845 53/97 (55%)
I-set 56..150 CDD:254352 53/96 (55%)
I-set 157..251 CDD:254352 42/93 (45%)
Ig2_Robo 159..251 CDD:143201 40/91 (44%)
I-set 255..341 CDD:254352 38/85 (45%)
Ig3_Robo 272..341 CDD:143202 32/68 (47%)
IG_like 351..436 CDD:214653 36/87 (41%)
Ig 362..444 CDD:299845 36/85 (42%)
I-set 445..531 CDD:254352 35/86 (41%)
IGc2 459..521 CDD:197706 21/62 (34%)
FN3 549..637 CDD:238020 27/87 (31%)
FN3 673..762 CDD:238020 22/89 (25%)
fn3 770..855 CDD:278470 28/87 (32%)
robo3XP_002937567.3 IgC_1_Robo 65..163 CDD:409490 53/97 (55%)
Ig strand B 82..86 CDD:409490 3/3 (100%)
Ig strand C 95..99 CDD:409490 2/3 (67%)
Ig strand E 122..126 CDD:409490 2/3 (67%)
Ig strand F 141..146 CDD:409490 2/4 (50%)
Ig strand G 155..158 CDD:409490 2/2 (100%)
Ig 170..255 CDD:416386 41/92 (45%)
Ig strand A 170..173 CDD:409353 1/2 (50%)
Ig strand A' 175..179 CDD:409353 1/3 (33%)
Ig strand B 183..190 CDD:409353 3/6 (50%)
Ig strand C 198..203 CDD:409353 2/4 (50%)
Ig strand C' 205..208 CDD:409353 0/2 (0%)
Ig strand D 214..218 CDD:409353 2/4 (50%)
Ig strand E 220..226 CDD:409353 3/5 (60%)
Ig strand F 233..241 CDD:409353 4/7 (57%)
Ig strand G 244..255 CDD:409353 5/10 (50%)
Ig 262..344 CDD:416386 36/82 (44%)
Ig strand A 262..265 CDD:409353 0/2 (0%)
Ig strand A' 267..271 CDD:409353 2/3 (67%)
Ig strand B 274..283 CDD:409353 2/8 (25%)
Ig strand C 289..294 CDD:409353 1/4 (25%)
Ig strand C' 297..300 CDD:409353 1/2 (50%)
Ig strand D 303..308 CDD:409353 2/4 (50%)
Ig strand E 309..316 CDD:409353 3/7 (43%)
Ig strand F 323..331 CDD:409353 4/7 (57%)
Ig strand G 334..344 CDD:409353 4/9 (44%)
Ig 353..449 CDD:416386 38/95 (40%)
Ig strand A 353..357 CDD:409353 0/3 (0%)
Ig strand A' 359..363 CDD:409353 0/3 (0%)
Ig strand B 369..377 CDD:409353 2/7 (29%)
Ig strand C 380..387 CDD:409353 5/6 (83%)
Ig strand C' 389..392 CDD:409353 1/2 (50%)
Ig strand D 405..410 CDD:409353 2/4 (50%)
Ig strand E 412..419 CDD:409353 3/6 (50%)
Ig strand F 425..434 CDD:409353 5/8 (63%)
Ig strand G 436..447 CDD:409353 2/10 (20%)
Ig 457..543 CDD:416386 34/85 (40%)
Ig strand A 457..460 CDD:409353 2/2 (100%)
Ig strand A' 464..467 CDD:409353 2/2 (100%)
Ig strand B 473..480 CDD:409353 1/6 (17%)
Ig strand C 486..491 CDD:409353 2/4 (50%)
Ig strand C' 493..495 CDD:409353 1/1 (100%)
Ig strand D 502..506 CDD:409353 1/3 (33%)
Ig strand E 509..514 CDD:409353 1/4 (25%)
Ig strand F 522..530 CDD:409353 5/7 (71%)
Ig strand G 533..543 CDD:409353 4/9 (44%)
FN3 561..655 CDD:238020 30/95 (32%)
FN3 687..766 CDD:238020 22/84 (26%)
fn3 774..861 CDD:394996 28/87 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 103 1.000 Domainoid score I6691
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 602 1.000 Inparanoid score I932
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D173520at2759
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 1 1.000 - - mtm9461
Panther 1 1.100 - - O PTHR12231
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X493
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

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