DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and robo4

DIOPT Version :9

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:XP_002937566.3 Gene:robo4 / 100493397 XenbaseID:XB-GENE-955396 Length:1166 Species:Xenopus tropicalis


Alignment Length:1514 Identity:328/1514 - (21%)
Similarity:481/1514 - (31%) Gaps:605/1514 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 PMHPENHAIARSTSTTNNPSRSRSSRMWLLPAWLLLVLVASNGLPAVRGQYQSPRIIEHPTDLVV 67
            |:..:.|.:..:...|.:....||:|...:..            ...|.:...|||||||:||.|
 Frog    29 PVINKEHGLEATRRQTRHVQHHRSTRRHRIRG------------SKTRSEDFPPRIIEHPSDLFV 81

  Fly    68 KKNEPATLNCKVEGKPEPTIEWFKDGEPVSTN-EKKSHR--VQFKDGALFFYRTMQGKKEQDGGE 129
            ||::||||.|:.||.|:|||||:::||.|.|: :.|:.|  ||..:|.|||:...|.|.:.|.|.
 Frog    82 KKDKPATLYCRAEGNPQPTIEWYRNGEHVETSTDDKTQRSYVQLPEGPLFFFSLNQRKGKSDEGI 146

  Fly   130 YWCVAKNRVGQAVSRHASLQIAVLRDDFRVEPKDTRVAKGETALLECGPPKGIPEPTLIWIKDGV 194
            |.|||:|.:|.|.||:|||.:|.||||||:.|.|..||.|:...:||.||||.|||.:.|.|||:
 Frog   147 YTCVARNHLGTAFSRNASLYVAALRDDFRLNPSDAVVAVGKQLEIECLPPKGHPEPNVTWKKDGI 211

  Fly   195 PLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSYAKLIVQVKPYFMK 259
            |::.       .:||..| ..|.|.|......|.|.|.|:|.|.||.|||..||::|..||.|..
 Frog   212 PINH-------NNSRYTI-SAGKLFIGKALKTDSGLYSCLASNQVGERESRAAKIVVLEKPMFTY 268

  Fly   260 EPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARILHDEKSLEISNITPTDEGTYVC 324
            :|.|....:|.|..|.|...|||.|...|.||.|:                              
 Frog   269 KPSDVTAKFGSTVQFGCGAQGDPKPTFHWSKENGD------------------------------ 303

  Fly   325 EAHNNVGQISARASLIVHAPPNFTKRPSNKKVGLNGVVQLPCMASGNPPPSVFWTKEGVSTLMFP 389
                                                                             
 Frog   304 ----------------------------------------------------------------- 303

  Fly   390 NSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQVSSLDERPPPIIQIGPANQ 454
                                                                             
 Frog   304 ----------------------------------------------------------------- 303

  Fly   455 TLPKGSVATLPCRATGNPSPRIKWFHDGHAVQAGNRYSIIQGSSLRVDDLQLSDSGTYTCTASGE 519
             ||:|                              ||.|...::||:..:.|.|||.|.|||..:
 Frog   304 -LPQG------------------------------RYEITNENTLRIRSVTLYDSGKYICTAGNQ 337

  Fly   520 RGETSWAATLTVEKPGSTSLHRAADPSTYPAPPGTPKVLNVSRTSISLRWAKSQEKPGAVGPIIG 584
            ....|..|.|||:.|                                                  
 Frog   338 LETVSAKALLTVQDP-------------------------------------------------- 352

  Fly   585 YTVEYFSPDLQTGWIVAAQRVGDTQVTISGLTPGTSYVFLVRAENTQGISVPSGLSNTIKTIEAD 649
                     |.||.|...:::                                            
 Frog   353 ---------LDTGQIEKERQI-------------------------------------------- 364

  Fly   650 FDAASANDLSAARTLLTGKSVELIDASAINASAVRLEWMLHVSADEKYVEGLRIHYKDASVPSAQ 714
                       .|.|: |..|.|.:.:|:.:::|.:.|  .|..:..:.||..:.|:..|...::
 Frog   365 -----------YRELM-GVRVHLDNITALPSASVYVHW--QVLTESPFTEGYSVFYRTLSSTESE 415

  Fly   715 YHSITVMDASAESFVVGNLKKYTKYEFFLTPFFETIEGQPSNSKTALTYEDVPSAPPDNIQIGMY 779
            :...|....:..|.|:.:|.:..||||.:.||.....|..||.|.....|:||:..|.||.:...
 Frog   416 WTEWTKSRINEYSTVIPSLWRGQKYEFKIRPFAGKNYGPDSNIKHLRIPEEVPNIAPQNINVTAV 480

  Fly   780 NQTAGW--VRWTPPPSQHHNGNLYGYKIEVSAGNTMKVLANMTLNATTTSVLLNNLTTGAVYSVR 842
            ....|.  |.|.|||...|:.|:.|||:......| ...|:..::..|.|:.:..|.:|..|.|:
 Frog   481 EGGNGTIVVSWEPPPKNIHSSNIKGYKVWCFENET-HPKADWIVDEETKSLEIPMLASGIKYQVQ 544

  Fly   843 LNSFTKAGDGPYSKPISLFMDPTHHVHPPRAHPSGTHDGRHEGQDLTYHNNGNIPPGDINPTTHK 907
            :.:...||.|..|.|..:.:|..                  |.:::...|           ...:
 Frog   545 VAAINDAGIGMPSIPKYIMIDSP------------------EVKEVKDEN-----------IYFE 580

  Fly   908 KTTDYLSGPWLMVLVCIVLLVLVISAAISMVYFKRKHQMTKE---LGH--LSVVSDNEITALNIN 967
            .....:..|..:..|..|..:|::.||:.:.....|...||:   ||:  ....|::.|....::
 Frog   581 LILQVVRHPAFIGTVGTVAWILLMVAAVYVCQRHSKRYSTKQHSILGNSLYRFASEDTIIKHRMD 645

  Fly   968 SKESLWIDHHRGWRTA----------------------DT----------DKDSGLSESKLLSHV 1000
            ..:|.|:.|  .|::|                      ||          ::.|..|.|:::..|
 Frog   646 ISDSPWLSH--TWKSASCSRNYSSTISMNSQLLWSETKDTADFHKSTMSFERKSEGSRSQIIPLV 708

  Fly  1001 NSSQSNYNNSDGGTDYAEVDTRNLTTFYNCR-----------KSPD-------NPTPY------- 1040
            ..|.|.|     ||.|.::..:::|||....           |:||       .|.|.       
 Frog   709 PDSNSLY-----GTMYVDLPGKDMTTFQRLPSDKSQGMGRHFKTPDPLGLLHHRPLPSYLNDFSG 768

  Fly  1041 ATTMIIGTSS--------------------SETCTKTTSISADKDSGTHSPYSDA--FAGQVPAV 1083
            :..|..||.|                    |:.|.|...   ..:|...|||..|  ....||::
 Frog   769 SNDMNGGTRSKLPWQPNINNNPDISFKDSWSKNCKKELQ---HANSAPLSPYCQAPKQGDSVPSI 830

  Fly  1084 ------PVVKSNY------------LQYP-----VEPINWSEFLPPPPEHPPPSSTYGYAQGSPE 1125
                  .|.|.:|            |.|.     ::.:.::..|||||. |||..       :|.
 Frog   831 QHLNIKKVGKGDYAKVMKTFSSPKILHYTTSLQVMDLLPYTPSLPPPPV-PPPDE-------NPI 887

  Fly  1126 SSRKSSKSAGSGIST----NQSILNASIHSSSSGGFSAWGVSPQYAVACPPENVYSNPLSAVAGG 1186
            .:.| .|.:|..:|:    ||......|:|....               ||:.:...|.|     
 Frog   888 HNDK-DKISGCSVSSYSVRNQEKQGHKINSKKKS---------------PPDTLNIKPAS----- 931

  Fly  1187 TQNRYQITPTNQH------PPQLPAYFATTGPGGAVPPNHLPFATQRHAASEYQAGLNAARCAQS 1245
                 :..|.|..      |..:..|...:..|          ...|| .|||.|.|        
 Frog   932 -----ECFPINDDGDNVLTPEDVAQYLELSDQG----------QNTRH-KSEYDASL-------- 972

  Fly  1246 RACNSCDALATPSPMQPPPPVPVPEGWYQPVHPNSHPMHPTSSNHQIYQCSSECSDHSRSSQSHK 1310
                       |.|..|                         |....|.||...|:.....:.. 
 Frog   973 -----------PRPFSP-------------------------SQTYGYICSPIPSEADVVDEDD- 1000

  Fly  1311 RQLQLEEHGSSAKQRGGHHRRRAPVVQPCMESENENMLA--------EYEQRQYTSDCCNSSREG 1367
             .|.||:.||....|.......:.:      ||.|:.:|        ...:..|||..|:     
 Frog  1001 -DLDLEDIGSLKSYRKYCETPTSSI------SEYESSMAGSLVNGWGSVSEDNYTSARCS----- 1053

  Fly  1368 DTCSCSEGSCL----YAEA 1382
             ..|.|:||.|    :|:|
 Frog  1054 -MVSSSDGSFLMDANFAKA 1071

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:299845 53/97 (55%)
I-set 56..150 CDD:254352 53/96 (55%)
I-set 157..251 CDD:254352 40/93 (43%)
Ig2_Robo 159..251 CDD:143201 38/91 (42%)
I-set 255..341 CDD:254352 16/85 (19%)
Ig3_Robo 272..341 CDD:143202 10/68 (15%)
IG_like 351..436 CDD:214653 0/84 (0%)
Ig 362..444 CDD:299845 0/81 (0%)
I-set 445..531 CDD:254352 19/85 (22%)
IGc2 459..521 CDD:197706 14/61 (23%)
FN3 549..637 CDD:238020 4/87 (5%)
FN3 673..762 CDD:238020 22/88 (25%)
fn3 770..855 CDD:278470 25/86 (29%)
robo4XP_002937566.3 Ig 70..168 CDD:416386 53/97 (55%)
Ig strand A 70..74 CDD:409353 3/3 (100%)
Ig strand A' 77..82 CDD:409353 2/4 (50%)
Ig strand B 86..94 CDD:409353 5/7 (71%)
Ig strand C 100..105 CDD:409353 4/4 (100%)
Ig strand C' 108..110 CDD:409353 1/1 (100%)
Ig strand D 121..125 CDD:409353 1/3 (33%)
Ig strand E 128..134 CDD:409353 4/5 (80%)
Ig strand F 145..153 CDD:409353 5/7 (71%)
Ig strand G 156..168 CDD:409353 7/11 (64%)
Ig 175..260 CDD:416386 39/92 (42%)
Ig strand A 175..178 CDD:409353 1/2 (50%)
Ig strand A' 180..184 CDD:409353 1/3 (33%)
Ig strand B 188..195 CDD:409353 2/6 (33%)
Ig strand C 203..208 CDD:409353 1/4 (25%)
Ig strand C' 210..213 CDD:409353 1/2 (50%)
Ig strand D 219..222 CDD:409353 1/2 (50%)
Ig strand E 225..231 CDD:409353 3/5 (60%)
Ig strand F 238..246 CDD:409353 4/7 (57%)
Ig strand G 249..260 CDD:409353 6/10 (60%)
Ig 269..349 CDD:416386 33/270 (12%)
Ig strand A' 272..276 CDD:409353 1/3 (33%)
Ig strand B 279..288 CDD:409353 3/8 (38%)
Ig strand C 294..299 CDD:409353 1/4 (25%)
Ig strand C' 302..305 CDD:409353 1/163 (1%)
Ig strand D 308..313 CDD:409353 3/4 (75%)
Ig strand E 314..321 CDD:409353 2/6 (33%)
Ig strand F 328..336 CDD:409353 5/7 (71%)
Ig strand G 339..349 CDD:409353 3/9 (33%)
FN3 377..462 CDD:238020 22/86 (26%)
fn3 471..557 CDD:394996 25/86 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 82 1.000 Domainoid score I8278
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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