DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and AMN1

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_009716.1	Gene:	AMN1 / 852455	SGDID:	S000000362	Length:	549	Species:	Saccharomyces cerevisiae

Alignment Length:	517	Identity:	104/517 - (20%)
Similarity:	187/517 - (36%)	Gaps:	149/517 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LYQQTELPGLTRTG------ATTTHHHLLRFTPYALHHRPPHHQLQTLPPALYLQHAAAAAAAAA 115
            |:|.:..||.::..      :..|....|:.:.....::...::..:.|.|..|::.|...|.|.
Yeast    58 LHQSSYNPGSSKVELVRPDLSLKTDQSFLQSSVQTTPNKKSCNEYLSTPEATPLKNTATENAWAT 122

  Fly   116 AAAAHAQHHHHHHHHLPHRPASPESPPPVEGTHISNL--------------------------FP 154
            :                 |..|..|...|..|.|.|:                          .|
Yeast   123 S-----------------RVVSASSLSIVTPTEIKNILVDEFSELKLGQPLTAQHQRSHAVFEIP 170

  Fly   155 ELLEQIFE--------HLPVRD--LGRAAQ----VCTAWRDAAYAKSVWKGVEAKL------HLK 199
            |::|.|.:        ::|...  |.|..|    ....::|...||..|...:...      |.:
Yeast   171 EIVENIIKMIVSLESANIPKERPCLRRNPQSYEHSLLMYKDEERAKKAWSAAQQLRDPPLVGHKE 235

  Fly   200 RSSPSLFNCLVKRGI----------KKVQILSLRRSLKDLVLGVPALTSLNLSGCF------NVA 248
            :...:||:|::...:          |.:...|: .:.|:.:......|.:.....|      .|.
Yeast   236 KKQGALFSCMMVNRLWLNVTRPFLFKSLHFKSV-HNFKEFLRTSQETTQVMRPSHFILHKLHQVT 299

  Fly   249 DMNLGHAFSVDLPNLKTLDLSLCKQIT------DTSLGRIAQHLRNLETLELGGCCNITNTGLLL 307
            ..::.....::..|||.|:..:|.:||      |        :|..||.|.:.|..||.:..||.
Yeast   300 QPDIERLSRMECQNLKWLEFYVCPRITPPLSWFD--------NLHKLEKLIIPGNKNIDDNFLLR 356

  Fly   308 IAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQG-- 370
            ::..:..||||.||:|.::||.|:..:|                  .:|.:|....:|...:|
Yeast   357 LSQSIPNLKHLVLRACDNVSDSGVVCIA------------------LNCPKLKTFNIGRHRRGNL 403

  Fly   371 -----------LTSLKSINLSFCVSVTDSGLKHLARM--PKLEQLNLRSCDNISDIGMAYLTEGG 422
                       .|.::::..:.| .|.|:|:...||:  ..:|:|:|.||..::|..:..|
Yeast   404 ITSVSLVALGKYTQVETVGFAGC-DVDDAGIWEFARLNGKNVERLSLNSCRLLTDYSLPIL---- 463

  Fly   423 SGINS------LDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQITDHGMLKIAKALHELEN 478
            ..:||      |::...|||:|  :.|..:  |.|...||: ..|......:|.|.:.:.||
Yeast   464 FALNSFPNLAVLEIRNLDKITD--VRHFVK--YNLWKKSLD-APILIEACERITKLIDQEEN 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	13/80 (16%)
		AMN1	<226..>334	CDD:187754	31/119 (26%)
		leucine-rich repeat	236..256	CDD:275381	3/25 (12%)
		leucine-rich repeat	263..288	CDD:275381	8/30 (27%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	11/31 (35%)
		AMN1	347..524	CDD:187754	35/153 (23%)
		leucine-rich repeat	348..373	CDD:275381	4/37 (11%)
		leucine-rich repeat	374..398	CDD:275381	6/25 (24%)
		leucine-rich repeat	399..424	CDD:275381	7/24 (29%)
		leucine-rich repeat	425..450	CDD:275381	8/30 (27%)
		leucine-rich repeat	451..475	CDD:275381	6/23 (26%)
		leucine-rich repeat	476..501	CDD:275381	2/3 (67%)
AMN1	NP_009716.1	AMN1	285..509	CDD:187754	61/259 (24%)
		leucine-rich repeat	314..337	CDD:275381	8/30 (27%)
		leucine-rich repeat	338..363	CDD:275381	8/24 (33%)
		leucine-rich repeat	364..389	CDD:275381	12/42 (29%)
		leucine-rich repeat	390..417	CDD:275381	3/26 (12%)
		leucine-rich repeat	418..443	CDD:275381	6/25 (24%)
		leucine-rich repeat	444..471	CDD:275381	9/30 (30%)
		leucine-rich repeat	472..493	CDD:275381	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810