Protein Alignment Ppa and AMN1

DIOPT Version :10

• Sequence 1: NP_001261138.1
• Gene: Ppa / 37602
• FlyBaseID: FBgn0020257
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_009716.1
• Gene: AMN1 / 852455
• SGDID: S000000362
• Length: 549
• Species: Saccharomyces cerevisiae
• Alignment Length: 517
• Identity: 104/517 - (20%)
• Similarity: 187/517 - (36%)
• Gaps: 149/517 - (28%)

  Fly    57 LYQQTELPGLTRTG------ATTTHHHLLRFTPYALHHRPPHHQLQTLPPALYLQHAAAAAAAAA 115
            |:|.:..||.::..      :..|....|:.:.....::...::..:.|.|..|::.|...|.|.
Yeast    58 LHQSSYNPGSSKVELVRPDLSLKTDQSFLQSSVQTTPNKKSCNEYLSTPEATPLKNTATENAWAT 122

  Fly   116 AAAAHAQHHHHHHHHLPHRPASPESPPPVEGTHISNL--------------------------FP 154
            :                 |..|..|...|..|.|.|:                          .|
Yeast   123 S-----------------RVVSASSLSIVTPTEIKNILVDEFSELKLGQPLTAQHQRSHAVFEIP 170

  Fly   155 ELLEQIFE--------HLPVRD--LGRAAQ----VCTAWRDAAYAKSVWKGVEAKL------HLK 199
            |::|.|.:        ::|...  |.|..|    ....::|...||..|...:...      |.:
Yeast   171 EIVENIIKMIVSLESANIPKERPCLRRNPQSYEHSLLMYKDEERAKKAWSAAQQLRDPPLVGHKE 235

  Fly   200 RSSPSLFNCLVKRGI----------KKVQILSLRRSLKDLVLGVPALTSLNLSGCF------NVA 248
            :...:||:|::...:          |.:...|: .:.|:.:......|.:.....|      .|.
Yeast   236 KKQGALFSCMMVNRLWLNVTRPFLFKSLHFKSV-HNFKEFLRTSQETTQVMRPSHFILHKLHQVT 299

  Fly   249 DMNLGHAFSVDLPNLKTLDLSLCKQIT------DTSLGRIAQHLRNLETLELGGCCNITNTGLLL 307
            ..::.....::..|||.|:..:|.:||      |        :|..||.|.:.|..||.:..||.
Yeast   300 QPDIERLSRMECQNLKWLEFYVCPRITPPLSWFD--------NLHKLEKLIIPGNKNIDDNFLLR 356

  Fly   308 IAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQG-- 370
            ::..:..||||.||:|.::||.|:..:|                  .:|.:|....:|...:|
Yeast   357 LSQSIPNLKHLVLRACDNVSDSGVVCIA------------------LNCPKLKTFNIGRHRRGNL 403

  Fly   371 -----------LTSLKSINLSFCVSVTDSGLKHLARM--PKLEQLNLRSCDNISDIGMAYLTEGG 422
                       .|.::::..:.| .|.|:|:...||:  ..:|:|:|.||..::|..:..|
Yeast   404 ITSVSLVALGKYTQVETVGFAGC-DVDDAGIWEFARLNGKNVERLSLNSCRLLTDYSLPIL---- 463

  Fly   423 SGINS------LDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQITDHGMLKIAKALHELEN 478
            ..:||      |::...|||:|  :.|..:  |.|...||: ..|......:|.|.:.:.||
Yeast   464 FALNSFPNLAVLEIRNLDKITD--VRHFVK--YNLWKKSLD-APILIEACERITKLIDQEEN 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box_FBXL14	150..190	CDD:438897	12/79 (15%)
		AMN1	<226..>334	CDD:187754	31/119 (26%)
		leucine-rich repeat	236..256	CDD:275381	3/25 (12%)
		leucine-rich repeat	263..288	CDD:275381	8/30 (27%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	11/31 (35%)
		AMN1	347..524	CDD:187754	35/153 (23%)
		leucine-rich repeat	348..373	CDD:275381	4/37 (11%)
		leucine-rich repeat	374..398	CDD:275381	6/25 (24%)
		leucine-rich repeat	399..424	CDD:275381	7/24 (29%)
		leucine-rich repeat	425..450	CDD:275381	8/30 (27%)
		leucine-rich repeat	451..475	CDD:275381	6/23 (26%)
		leucine-rich repeat	476..501	CDD:275381	2/3 (67%)
AMN1	NP_009716.1	AMN1	285..509	CDD:187754	61/259 (24%)
		leucine-rich repeat	314..337	CDD:275381	8/30 (27%)
		leucine-rich repeat	338..363	CDD:275381	8/24 (33%)
		leucine-rich repeat	364..389	CDD:275381	12/42 (29%)
		leucine-rich repeat	390..417	CDD:275381	3/26 (12%)
		leucine-rich repeat	418..443	CDD:275381	6/25 (24%)
		leucine-rich repeat	444..471	CDD:275381	9/30 (30%)
		leucine-rich repeat	472..493	CDD:275381	6/24 (25%)