DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and VFB1

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_175151.1	Gene:	VFB1 / 841121	AraportID:	AT1G47056	Length:	518	Species:	Arabidopsis thaliana

Alignment Length:	443	Identity:	106/443 - (23%)
Similarity:	176/443 - (39%)	Gaps:	93/443 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 PVEG--------THISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLK 199
            |:|.        .:.|:|..|.|..:|:.|...:..|.|.||..|............:.|:..|.
plant    26 PIESIESEISQPDYTSSLPDECLALVFQFLNSGNRKRCALVCRRWMIVEGQNRYRLSLHARSDLI 90

  Fly   200 RSSPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLK 264
            .|.||||:     ....|..|||:...:.:.:|..||..::|. |                .|||
plant    91 TSIPSLFS-----RFDSVTKLSLKCDRRSVSIGDEALVKISLR-C----------------RNLK 133

  Fly   265 TLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQ 329
            .|.|..|:::||..:...|::.::|:....|.|           .:|.|.:|.: |..|.::.:.
plant   134 RLKLRACRELTDVGMAAFAENCKDLKIFSCGSC-----------DFGAKGVKAV-LDHCSNLEEL 186

  Fly   330 GIGHLAGFSRETAE------GNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFC------ 382
            .|..|.||:....|      ....|:.:.|::.  .:.:..|.:..|..:|||:.|..|
plant   187 SIKRLRGFTDIAPEMIGPGVAASSLKSICLKEL--YNGQCFGPVIVGAKNLKSLKLFRCSGDWDL 249

  Fly   383 ----VSVTDSGLK--HLARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQAL 441
                :|..|.|:.  ||.||            .:||:.::.::. .|.:.||.:....:.::..|
plant   250 LLQEMSGKDHGVVEIHLERM------------QVSDVALSAISY-CSSLESLHLVKTPECTNFGL 301

  Fly   442 THIAQGLYRLRSLSLNQCQ---ITDHGMLKIAKALHELENL-NIGQCSRITDKGLQTLAEDLTNL 502
            ..||:...|||.|.::..:   |.|.|::.:||...:|:.| .||  ...|...|..||....||
plant   302 AAIAEKCKRLRKLHIDGWKANLIGDEGLVAVAKFCSQLQELVLIG--VNPTTLSLGMLAAKCLNL 364

  Fly   503 KTIDLYGCTQLSSKGID-IIMKLPKLQKLNLGLWLVRXC------VHHDCNAC 548
            :.:.|.||.......:. |..|.|.|:||     .::.|      :.:..|.|
plant   365 ERLALCGCDTFGDPELSCIAAKCPALRKL-----CIKNCPISDVGIENLANGC 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	11/40 (28%)
		AMN1	<226..>334	CDD:187754	23/107 (21%)
		leucine-rich repeat	236..256	CDD:275381	3/19 (16%)
		leucine-rich repeat	263..288	CDD:275381	8/24 (33%)
		leucine-rich repeat	289..314	CDD:275381	4/24 (17%)
		leucine-rich repeat	315..347	CDD:275381	8/37 (22%)
		AMN1	347..524	CDD:187754	47/193 (24%)
		leucine-rich repeat	348..373	CDD:275381	4/24 (17%)
		leucine-rich repeat	374..398	CDD:275381	12/35 (34%)
		leucine-rich repeat	399..424	CDD:275381	2/24 (8%)
		leucine-rich repeat	425..450	CDD:275381	5/24 (21%)
		leucine-rich repeat	451..475	CDD:275381	8/26 (31%)
		leucine-rich repeat	476..501	CDD:275381	8/25 (32%)
VFB1	NP_175151.1	F-box-like	41..>70	CDD:403981	10/28 (36%)
		AMN1	87..>202	CDD:187754	37/148 (25%)
		leucine-rich repeat	103..125	CDD:275381	7/21 (33%)
		leucine-rich repeat	132..157	CDD:275381	8/24 (33%)
		leucine-rich repeat	158..182	CDD:275381	8/35 (23%)
		leucine-rich repeat	183..224	CDD:275381	7/42 (17%)
		leucine-rich repeat	235..260	CDD:275381	7/24 (29%)
		leucine-rich repeat	261..284	CDD:275381	6/35 (17%)
		AMN1	271..>412	CDD:187754	38/148 (26%)
		leucine-rich repeat	285..310	CDD:275381	5/24 (21%)
		leucine-rich repeat	311..338	CDD:275381	8/26 (31%)
		leucine-rich repeat	339..363	CDD:275381	8/25 (32%)
		leucine-rich repeat	364..389	CDD:275381	6/24 (25%)
		leucine-rich repeat	390..414	CDD:275381	6/28 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810