DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and SKP2A

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001321134.1	Gene:	SKP2A / 838740	AraportID:	AT1G21410	Length:	360	Species:	Arabidopsis thaliana

Alignment Length:	437	Identity:	107/437 - (24%)
Similarity:	166/437 - (37%)	Gaps:	143/437 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 ELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQI 219
            |||.:|...:..|::..|:.|||.||||                           :..|:.::::
plant    34 ELLMRILSLVDDRNVIVASGVCTGWRDA---------------------------ISFGLTRLRL 71

  Fly   220 LSLRRSLKDLVLG-VPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCK-QITDTSLGRI 282
            .....::..|||. ||...                        .|:||:|...| |:.|.::..|
plant    72 SWCNNNMNSLVLSLVPKFV------------------------KLQTLNLRQDKPQLEDNAVEAI 112

  Fly   283 AQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQ 347
            |.|...|:.|:|.....||:..|..:|.|...|..|||..|...||..|.:|..|.|:
plant   113 ANHCHELQELDLSKSLKITDRSLYALAHGCPDLTKLNLSGCTSFSDTAIAYLTRFCRK------- 170

  Fly   348 LEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCV-SVTDSGLKHLA-RMPKLEQLNLRSCDNI 410
                                      ||.:||..|| :|||:.|:.:. ...:::.|||..|:||
plant   171 --------------------------LKVLNLCGCVKAVTDNALEAIGNNCNQMQSLNLGWCENI 209

  Fly   411 SDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQ-ITDHGMLKIA---- 470
            ||.|:..|..|...:.:||:..|..|:|:::..:|.....||||.|..|: |||..|..:|
plant   210 SDDGVMSLAYGCPDLRTLDLCGCVLITDESVVALADWCVHLRSLGLYYCRNITDRAMYSLAQSGV 274

  Fly   471 -----------KALHE---LENLNIGQCSRITDKGLQTLAEDLTNLKT------IDLYGCTQLSS 515
                       |..::   |.:|||.||:.:|...:|.:.:....|.|      :.:.||..|::
plant   275 KNKPGSWKSVKKGKYDEEGLRSLNISQCTALTPSAVQAVCDSFPALHTCSGRHSLVMSGCLNLTT 339

  Fly   516 KGIDIIMKLPKLQKLNLGLWLVRXCVHHDCNACAAKEAARGSYNSQP 562
                                     ||     ||....|..::|:.|
plant   340 -------------------------VH-----CACILQAHRAHNAVP 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	13/34 (38%)
		AMN1	<226..>334	CDD:187754	31/109 (28%)
		leucine-rich repeat	236..256	CDD:275381	0/19 (0%)
		leucine-rich repeat	263..288	CDD:275381	10/25 (40%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	11/31 (35%)
		AMN1	347..524	CDD:187754	52/203 (26%)
		leucine-rich repeat	348..373	CDD:275381	0/24 (0%)
		leucine-rich repeat	374..398	CDD:275381	10/25 (40%)
		leucine-rich repeat	399..424	CDD:275381	11/24 (46%)
		leucine-rich repeat	425..450	CDD:275381	6/24 (25%)
		leucine-rich repeat	451..475	CDD:275381	12/39 (31%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
SKP2A	NP_001321134.1	F-box-like	28..>63	CDD:403981	13/55 (24%)
		leucine-rich repeat	66..91	CDD:275381	5/48 (10%)
		leucine-rich repeat	92..118	CDD:275381	10/25 (40%)
		AMN1	<115..264	CDD:187754	55/181 (30%)
		leucine-rich repeat	119..144	CDD:275381	8/24 (33%)
		leucine-rich repeat	145..170	CDD:275381	10/24 (42%)
		leucine-rich repeat	171..197	CDD:275381	10/25 (40%)
		leucine-rich repeat	198..223	CDD:275381	11/24 (46%)
		leucine-rich repeat	224..249	CDD:275381	6/24 (25%)
		leucine-rich repeat	250..272	CDD:275381	11/21 (52%)
		leucine-rich repeat	294..313	CDD:275381	8/18 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810