DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and AFB3

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_563915.1	Gene:	AFB3 / 837838	AraportID:	AT1G12820	Length:	577	Species:	Arabidopsis thaliana

Alignment Length:	427	Identity:	96/427 - (22%)
Similarity:	167/427 - (39%)	Gaps:	91/427 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 NLFP-ELLEQIFEHLPV-RDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRG 213
            |.|| |::|.:|:.:.. :|....:.||.:|..          :|   ...|....:.||..
plant     2 NYFPDEVIEHVFDFVASHKDRNSISLVCKSWHK----------IE---RFSRKEVFIGNCYA--- 50

  Fly   214 IKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNL-GHAFSVDL-PNLKTL--------DL 268
                  ::..|    |:...|.|.||.|.|..:.||.|| .|.:...: |.::.|        :|
plant    51 ------INPER----LIRRFPCLKSLTLKGKPHFADFNLVPHEWGGFVHPWIEALARSRVGLEEL 105

  Fly   269 SLCKQ-ITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIG 332
            .|.:. :||.||..:::...|.::|.|..|...|..||..||...:.|:.|:|:.  :..|...|
plant   106 RLKRMVVTDESLDLLSRSFANFKSLVLVSCEGFTTDGLASIAANCRHLRELDLQE--NEIDDHRG 168

  Fly   333 HLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARM- 396
            .......::....:.|.:..|:....::  ||..:.....:|||:.|:..|.     |..|||:
plant   169 QWLNCFPDSCTTLMSLNFACLKGETNVA--ALERLVARSPNLKSLKLNRAVP-----LDALARLM 226

  Fly   397 ---PKLEQLNLRSCDNISD-----------------------IGMAYLTEGG-----SGINSLDV 430
               |:|..|.:.|.:|..|                       :.:|.|....     ..:.||::
plant   227 SCAPQLVDLGVGSYENEPDPESFAKLMTAIKKYTSLRSLSGFLEVAPLCLPAFYPICQNLISLNL 291

  Fly   431 SFCDKISDQALTHIAQGLYRLRSLSLNQCQITDHGMLKIAKALHELENLNI---------GQCSR 486
            |:..:|....|..:.|...||:.|.:.. .|.|.|:..:|....||:.|.:         ...:.
plant   292 SYAAEIQGNHLIKLIQLCKRLQRLWILD-SIGDKGLAVVAATCKELQELRVFPSDVHGEEDNNAS 355

  Fly   487 ITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDIIMK 523
            :|:.||..::.....|.:| ||.|.|:::..:..:.|
plant   356 VTEVGLVAISAGCPKLHSI-LYFCKQMTNAALIAVAK 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	10/40 (25%)
		AMN1	<226..>334	CDD:187754	34/118 (29%)
		leucine-rich repeat	236..256	CDD:275381	10/20 (50%)
		leucine-rich repeat	263..288	CDD:275381	7/33 (21%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	5/31 (16%)
		AMN1	347..524	CDD:187754	47/218 (22%)
		leucine-rich repeat	348..373	CDD:275381	4/24 (17%)
		leucine-rich repeat	374..398	CDD:275381	9/27 (33%)
		leucine-rich repeat	399..424	CDD:275381	7/52 (13%)
		leucine-rich repeat	425..450	CDD:275381	6/24 (25%)
		leucine-rich repeat	451..475	CDD:275381	6/23 (26%)
		leucine-rich repeat	476..501	CDD:275381	5/33 (15%)
AFB3	NP_563915.1	F-box_5	1..42	CDD:408301	12/52 (23%)
		leucine-rich repeat	35..62	CDD:275381	6/42 (14%)
		Transp_inhibit	61..107	CDD:408562	14/45 (31%)
		leucine-rich repeat	102..126	CDD:275381	6/23 (26%)
		leucine-rich repeat	127..152	CDD:275381	8/24 (33%)
		leucine-rich repeat	153..207	CDD:275381	9/57 (16%)
		leucine-rich repeat	208..255	CDD:275381	15/51 (29%)
		AMN1	262..>393	CDD:187754	28/132 (21%)
		leucine-rich repeat	286..311	CDD:275381	6/24 (25%)
		leucine-rich repeat	312..335	CDD:275381	6/23 (26%)
		leucine-rich repeat	336..370	CDD:275381	5/33 (15%)
		leucine-rich repeat	371..395	CDD:275381	7/22 (32%)
		leucine-rich repeat	396..430	CDD:275381
		leucine-rich repeat	431..454	CDD:275381
		leucine-rich repeat	455..479	CDD:275381
		leucine-rich repeat	505..529	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820