DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and VFB3

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_567316.1	Gene:	VFB3 / 826171	AraportID:	AT4G07400	Length:	554	Species:	Arabidopsis thaliana

Alignment Length:	448	Identity:	102/448 - (22%)
Similarity:	172/448 - (38%)	Gaps:	105/448 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 HISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSS------PSLF 206
            :||||..|.|..||:.|...||.|.:.||..|      .::......:|.||..|      ||||
plant    73 YISNLPDECLSLIFQSLTCADLKRCSLVCRRW------LTIEGQCRHRLSLKAQSDLISVIPSLF 131

  Fly   207 NCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLC 271
            ...  ..:.|:.:.|.|||     ||:          |.|...|     .||...||..|.|..|
plant   132 TRF--DSVTKLVLRSDRRS-----LGI----------CDNAFVM-----ISVRCRNLTRLKLRGC 174

  Fly   272 KQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAG 336
            .:|:|..:....::.|:|:.:..|.|           .:|:|.:..| |.:|..:.:..:..|.|
plant   175 PEISDLGIIGFTENCRSLKKVSFGSC-----------GFGVKGMNAL-LNTCLGLEELSVKRLRG 227

  Fly   337 FSRET-------AEGNLQ----------------------LEYLGLQDCQRLSDEALGHIAQGLT 372
            .....       |.|:|:                      |..|.:..|....|.....:...:.
plant   228 IGAGAELIGPGGAAGSLKVICLKELHNGQCFAPLLSGAKGLRILKIFRCSGDWDRVFEAVRDKVN 292

  Fly   373 SLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVS--FCDK 435
            ::..|:|. .:.::|.||..|::...:|.|:|....:.:::|:|.:.|....:..|.:.  ..::
plant   293 AIVEIHLE-RIQMSDLGLTALSKCSGVEVLHLVKTPDCTNVGLALVAERCKLLRKLHIDGWKTNR 356

  Fly   436 ISDQALTHIAQGLYRLRSLSL--------------NQC------------QITDHGMLKIAKALH 474
            |.|:.|..:|:..:.|:.|.|              :.|            .:.|..:..||:...
plant   357 IGDEGLIVVAKYCWNLQELVLIGVNPTKLSLEAIVSNCLNLERLALCGSDTVGDTELCCIAEKCL 421

  Fly   475 ELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDIIMKLPKLQKLNL 532
            .|..|.|..|. |||.|::.|.....||..:.:..|..::::|.|::.|...|..:||
plant   422 ALRKLCIKNCP-ITDDGIKALGNGCPNLLKVKVKKCRGVTTQGADLLRKRRALLVVNL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	15/40 (38%)
		AMN1	<226..>334	CDD:187754	23/107 (21%)
		leucine-rich repeat	236..256	CDD:275381	3/19 (16%)
		leucine-rich repeat	263..288	CDD:275381	6/24 (25%)
		leucine-rich repeat	289..314	CDD:275381	4/24 (17%)
		leucine-rich repeat	315..347	CDD:275381	7/38 (18%)
		AMN1	347..524	CDD:187754	42/226 (19%)
		leucine-rich repeat	348..373	CDD:275381	4/24 (17%)
		leucine-rich repeat	374..398	CDD:275381	6/23 (26%)
		leucine-rich repeat	399..424	CDD:275381	6/24 (25%)
		leucine-rich repeat	425..450	CDD:275381	5/26 (19%)
		leucine-rich repeat	451..475	CDD:275381	7/49 (14%)
		leucine-rich repeat	476..501	CDD:275381	9/24 (38%)
VFB3	NP_567316.1	F-box-like	74..>104	CDD:289689	14/29 (48%)
		leucine-rich repeat	89..114	CDD:275381	7/30 (23%)
		leucine-rich repeat	115..165	CDD:275381	20/71 (28%)
		AMN1	<146..>226	CDD:187754	26/111 (23%)
		leucine-rich repeat	166..191	CDD:275381	6/24 (25%)
		leucine-rich repeat	192..216	CDD:275381	8/35 (23%)
		leucine-rich repeat	268..293	CDD:275381	4/24 (17%)
		leucine-rich repeat	294..317	CDD:275381	6/23 (26%)
		leucine-rich repeat	318..343	CDD:275381	6/24 (25%)
		AMN1	<340..>463	CDD:187754	24/123 (20%)
		leucine-rich repeat	344..371	CDD:275381	5/26 (19%)
		leucine-rich repeat	372..396	CDD:275381	4/23 (17%)
		leucine-rich repeat	397..422	CDD:275381	3/24 (13%)
		leucine-rich repeat	423..447	CDD:275381	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810