DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ppa and lrrc29

DIOPT Version :9

Sequence 1:NP_001261138.1 Gene:Ppa / 37602 FlyBaseID:FBgn0020257 Length:562 Species:Drosophila melanogaster
Sequence 2:XP_001339819.4 Gene:lrrc29 / 799466 ZFINID:ZDB-GENE-030131-7165 Length:644 Species:Danio rerio


Alignment Length:635 Identity:136/635 - (21%)
Similarity:227/635 - (35%) Gaps:253/635 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   144 VEGTHISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAY------------------------ 184
            :|..|:.:   |::..||..|.|.|...|:.||.:|.:|:.                        
Zfish     1 MESLHLPS---EIITYIFSFLHVMDRKEASLVCKSWYNASQDYPFKRNLTFKFPASSSSLGFIRG 62

  Fly   185 ---------------AKSVWKGV--EAKLHLKRSSPSLF--------NCLVK-----RGIKKVQI 219
                           ..||.:.|  |..|||.....||.        :||::     ..::|:.:
Zfish    63 LARHPRCGLVISHLDGSSVSRQVLLEVGLHLGPRLDSLALPGSSITESCLLELLPRLTSLRKLDL 127

  Fly   220 ---------------------------------LSLRRSLKD-----LVLGVPALTSLNLSGC-- 244
                                             ||..|.|.|     |.:..|.|..|:||||  
Zfish   128 QGLDSLFMSGAFLSREEHRRKVYRALLNLEELNLSNLRYLSDLSFNRLTICTPGLRRLSLSGCHI 192

  Fly   245 ------FNVADMNLGHAFSVDLPN-----------LKTLDLSL---------------------- 270
                  :....:..|.:..|.|.|           |::||||.                      
Zfish   193 SFEFDPYRGCPVGSGSSALVSLRNLLNLLQKQTSTLRSLDLSRTGITPKSLRSISKLRGLRLEEL 257

  Fly   271 ----CKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGI 331
                ||::||.|:..:.::...|..|:|.||..::...:|.:...||:|:.|:....|.|:|:|:
Zfish   258 NLHGCKELTDYSIEILCKYQSGLRMLDLSGCMELSCRAVLAVGAELKELRVLSFSQDWKITDKGL 322

  Fly   332 G-----------------HLAGFSRETAEG------NLQLEYLGLQDCQRLSDEALGHIAQGL-T 372
            .                 |::|  .|..:|      ..|:|.|.|::|..:.|..:..:||.| .
Zfish   323 AELMMLPHLRSLDLSECLHVSG--TELVKGLSGPEPRAQVETLSLRNCTYIRDSVVFSLAQLLGV 385

  Fly   373 SLKSINLSFCVSVTDSGLKHLAR-MPKLEQLNLRSCDNISDIGMAYLTE---------------- 420
            .|:.::||.||.:||..::.:|. :|.|..|.|..|..|||.|:..:||                
Zfish   386 HLRELDLSSCVYLTDLSVRAIATFLPALLVLRLGWCKEISDWGLLGMTEPTKHCQPSDREEDKGP 450

  Fly   421 ------GGSG-------------------------------------INSLDVSFCDKISDQALT 442
                  |..|                                     :..|:::.|.|::|.::|
Zfish   451 SFTRTFGNMGFFQPPSLPFQDKPRLVTDEDLEEFRDQQGASLLALRELQVLELTACSKLTDTSIT 515

  Fly   443 HIAQ--GLYR-----------------------LRSLSLNQC-QITDHGMLKIAKALHELENLNI 481
            .:.:  .|.|                       |.||||:.| ||:|.||.:....||.|::|.:
Zfish   516 QVLRFPELQRLSLSMLPEITDDSLVSVALHCCSLTSLSLSHCPQISDKGMARALPLLHRLQHLYL 580

  Fly   482 GQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDIIM-KLPKLQKL 530
            ..|:.||::.|..:|.....|:|:|:..|..::...:|::. :||.|:|:
Zfish   581 ACCNAITNETLSIIALHCDRLRTLDVSMCKDITVHQVDLLQSRLPFLEKV 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpaNP_001261138.1 F-box-like 149..190 CDD:289689 13/79 (16%)
AMN1 <226..>334 CDD:187754 38/174 (22%)
leucine-rich repeat 236..256 CDD:275381 7/27 (26%)
leucine-rich repeat 263..288 CDD:275381 10/50 (20%)
leucine-rich repeat 289..314 CDD:275381 7/24 (29%)
leucine-rich repeat 315..347 CDD:275381 10/54 (19%)
AMN1 347..524 CDD:187754 62/264 (23%)
leucine-rich repeat 348..373 CDD:275381 8/25 (32%)
leucine-rich repeat 374..398 CDD:275381 8/24 (33%)
leucine-rich repeat 399..424 CDD:275381 11/46 (24%)
leucine-rich repeat 425..450 CDD:275381 6/26 (23%)
leucine-rich repeat 451..475 CDD:275381 12/24 (50%)
leucine-rich repeat 476..501 CDD:275381 7/24 (29%)
lrrc29XP_001339819.4 F-box-like 4..49 CDD:289689 12/47 (26%)
leucine-rich repeat 71..96 CDD:275381 7/24 (29%)
leucine-rich repeat 97..121 CDD:275381 4/23 (17%)
leucine-rich repeat 122..179 CDD:275381 7/56 (13%)
leucine-rich repeat 182..227 CDD:275381 10/44 (23%)
AMN1 215..427 CDD:187754 53/213 (25%)
leucine-rich repeat 228..253 CDD:275381 5/24 (21%)
leucine-rich repeat 254..277 CDD:275381 5/22 (23%)
leucine-rich repeat 280..305 CDD:275381 7/24 (29%)
leucine-rich repeat 306..325 CDD:275381 6/18 (33%)
leucine-rich repeat 331..359 CDD:275381 4/29 (14%)
leucine-rich repeat 360..386 CDD:275381 8/25 (32%)
leucine-rich repeat 387..412 CDD:275381 8/24 (33%)
leucine-rich repeat 413..497 CDD:275381 12/83 (14%)
AMN1 <498..613 CDD:187754 31/114 (27%)
leucine-rich repeat 498..522 CDD:275381 5/23 (22%)
leucine-rich repeat 523..548 CDD:275381 2/24 (8%)
leucine-rich repeat 549..574 CDD:275381 12/24 (50%)
leucine-rich repeat 575..598 CDD:275381 7/22 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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