DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and fbxl17

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_001335097.5	Gene:	fbxl17 / 795023	ZFINID:	ZDB-GENE-111013-3	Length:	409	Species:	Danio rerio

Alignment Length:	295	Identity:	71/295 - (24%)
Similarity:	128/295 - (43%)	Gaps:	58/295 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 PPHHQLQTLPPALYLQHAAAAAAAAAAAAAHAQHHHHHHHHLP-------------HRPASPE-- 139
            |..|.|  ||....|..::::::::|:....|....|..   |             ...||.|
Zfish   152 PDSHCL--LPSICPLPSSSSSSSSSASEEDGATAGRHSD---PGGATTCSSSSCCCQTEASEEIK 211

  Fly   140 SPPPVEGTHISNLFPELLEQIFEHLPVRDLGRAAQ-VCTAWRDAAYAKSVWKGVEAKLHLKRSSP 203
            |....:.:||:.|...:|.::|.||.|::...||. ||..|||.......||.::..
Zfish   212 STENTDTSHINQLPSSILLKVFSHLSVKERCLAASLVCKYWRDLCLDFQFWKQIDLS-------- 268

  Fly   204 SLFNCLVKRGIKKVQILSLRRSLKDLVLGVPA----LTSLNLSGCFNVADMNLGHAFSVDLPNLK 264
                     |:::|:        .||::.:.:    :|.:|:|.|.||.|..: .|.:.:...|.
Zfish   269 ---------GLQQVK--------DDLLVKIASRRQNVTEINISDCRNVQDHGV-CALASNCAGLI 315

  Fly   265 TLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQ 329
            ......|||::|.||..:|.|...|:.:.:|....:|:..|.|:....|:||.::...|:.|||:
Zfish   316 KYTAYRCKQLSDVSLSTVAIHCPLLQKVHVGNQDKLTDHALKLLGDHCKELKDVHFGQCYSISDE 380

  Fly   330 GIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEAL 364
            |:..|       |:|..:|:.:.:|:.:.:|...:
Zfish   381 GLMSL-------AQGCNKLQRIYMQENKLVSQAGI 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	14/41 (34%)
		AMN1	<226..>334	CDD:187754	32/111 (29%)
		leucine-rich repeat	236..256	CDD:275381	7/19 (37%)
		leucine-rich repeat	263..288	CDD:275381	9/24 (38%)
		leucine-rich repeat	289..314	CDD:275381	5/24 (21%)
		leucine-rich repeat	315..347	CDD:275381	10/31 (32%)
		AMN1	347..524	CDD:187754	3/18 (17%)
		leucine-rich repeat	348..373	CDD:275381	3/17 (18%)
		leucine-rich repeat	374..398	CDD:275381
		leucine-rich repeat	399..424	CDD:275381
		leucine-rich repeat	425..450	CDD:275381
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
fbxl17	XP_001335097.5	F-box-like	221..268	CDD:289689	16/46 (35%)
		AMN1	257..>397	CDD:187754	40/172 (23%)
		leucine-rich repeat	262..287	CDD:275381	6/49 (12%)
		leucine-rich repeat	288..313	CDD:275381	8/25 (32%)
		leucine-rich repeat	314..339	CDD:275381	9/24 (38%)
		leucine-rich repeat	340..365	CDD:275381	5/24 (21%)
		leucine-rich repeat	366..391	CDD:275381	10/31 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810