DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and amn1

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001038919.1	Gene:	amn1 / 751744	ZFINID:	ZDB-GENE-060825-13	Length:	249	Species:	Danio rerio

Alignment Length:	336	Identity:	77/336 - (22%)
Similarity:	131/336 - (38%)	Gaps:	109/336 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 LVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLG---HAFSVDLPNLKTLDLSL 270
            :.:|..|...|..|..|:||.:|.:  :||..     .|.|.|:.   |:      ...||||..
Zfish    15 VAQRAEKYEDIRMLPASVKDRLLRI--MTSYG-----TVTDSNISQLVHS------GTHTLDLQN 66

  Fly   271 CKQITDTSLGRI-AQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHL 334
            || |:|::|.:| :.|||   |:.|.||..||:.||.::|           ..|.:
Zfish    67 CK-ISDSALKQINSLHLR---TILLRGCAEITSEGLEVLA-----------PRCPY--------- 107

  Fly   335 AGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPK- 398
                                                   |:.::|:.|.:|||||::.|||..|
Zfish   108 ---------------------------------------LQVVDLTGCTAVTDSGIQALARHCKC 133

  Fly   399 LEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQITD 463
            ||.::||.                          |..:||:||..:......|.|:..:..::||
Zfish   134 LEVISLRG--------------------------CSALSDKALLELGGNCKMLHSIYFSGTEVTD 172

  Fly   464 HGMLKIAKAL--HELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDIIMKLPK 526
            .|::.:|..:  ..|:.|.:.:|..:||..:..:..:..|::..:.:||..::.|..:.:..|..
Zfish   173 QGVIGLATGVCSCSLKELQMVRCRNLTDLAVTAVLTNCANIRIFNFHGCPLITDKSREALQNLIG 237

  Fly   527 LQKLNLGLWLV 537
            ..|:....|.|
Zfish   238 PNKIQQVSWTV 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689
		AMN1	<226..>334	CDD:187754	32/111 (29%)
		leucine-rich repeat	236..256	CDD:275381	6/22 (27%)
		leucine-rich repeat	263..288	CDD:275381	12/25 (48%)
		leucine-rich repeat	289..314	CDD:275381	9/24 (38%)
		leucine-rich repeat	315..347	CDD:275381	1/31 (3%)
		AMN1	347..524	CDD:187754	36/179 (20%)
		leucine-rich repeat	348..373	CDD:275381	0/24 (0%)
		leucine-rich repeat	374..398	CDD:275381	11/23 (48%)
		leucine-rich repeat	399..424	CDD:275381	4/24 (17%)
		leucine-rich repeat	425..450	CDD:275381	5/24 (21%)
		leucine-rich repeat	451..475	CDD:275381	6/25 (24%)
		leucine-rich repeat	476..501	CDD:275381	5/24 (21%)
amn1	NP_001038919.1	AMN1	33..248	CDD:187754	71/316 (22%)
		leucine-rich repeat	59..72	CDD:275381	7/13 (54%)
		leucine-rich repeat	82..107	CDD:275381	12/38 (32%)
		leucine-rich repeat	108..133	CDD:275381	11/24 (46%)
		leucine-rich repeat	134..159	CDD:275381	9/50 (18%)
		leucine-rich repeat	160..186	CDD:275381	6/25 (24%)
		leucine-rich repeat	187..212	CDD:275381	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900