DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and Fbxl20

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_006534361.1	Gene:	Fbxl20 / 72194	MGIID:	1919444	Length:	438	Species:	Mus musculus

Alignment Length:	393	Identity:	122/393 - (31%)
Similarity:	187/393 - (47%)	Gaps:	55/393 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 ELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGI--KKV 217
            |||.:||..|.|..|.|.|||..||...|...|.|:.::           ||:  .:|.|  :.|
Mouse    33 ELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRID-----------LFD--FQRDIEGRVV 84

  Fly   218 QILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITD---TSL 279
            :.:|.|..        ..|..|:|.||..|.| |....|:.:..|::.|.|:.|.:.||   |||
Mouse    85 ENISKRCG--------GFLRKLSLRGCLGVGD-NALRTFAQNCRNIEVLSLNGCTKTTDATCTSL 140

  Fly   280 GRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHL----AGFSRE 340
            .:....||:   |:|..|.:|||..|..::.|...|:.||:..|..::..||..|    .|....
Mouse   141 SKFCSKLRH---LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKAL 202

  Fly   341 TAEGNLQLE-----YLG----------LQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGL 390
            ..:|..|||     |:|          ||.|.:::||.|..|.:|...|:|:..|.|.::||:.|
Mouse   203 FLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAIL 267

  Fly   391 KHLAR-MPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSL 454
            ..|.: .|:|..|.:..|..::|:|...|......:..:|:..|.:|:|..|..::....||:.|
Mouse   268 NALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVL 332

  Fly   455 SLNQCQ-ITDHGMLKI---AKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSS 515
            ||:.|: |||.|:..:   |.|..:||.:.:..|..|||..|:.| :...:|:.|:||.|.|::.
Mouse   333 SLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSLERIELYDCQQITR 396

  Fly   516 KGI 518
            .||
Mouse   397 AGI 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	16/34 (47%)
		AMN1	<226..>334	CDD:187754	34/110 (31%)
		leucine-rich repeat	236..256	CDD:275381	8/19 (42%)
		leucine-rich repeat	263..288	CDD:275381	9/27 (33%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	9/35 (26%)
		AMN1	347..524	CDD:187754	61/192 (32%)
		leucine-rich repeat	348..373	CDD:275381	12/39 (31%)
		leucine-rich repeat	374..398	CDD:275381	8/24 (33%)
		leucine-rich repeat	399..424	CDD:275381	6/24 (25%)
		leucine-rich repeat	425..450	CDD:275381	5/24 (21%)
		leucine-rich repeat	451..475	CDD:275381	11/27 (41%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
Fbxl20	XP_006534361.1	F-box-like	30..71	CDD:403981	17/37 (46%)
		leucine-rich repeat	67..94	CDD:275381	8/47 (17%)
		AMN1	95..291	CDD:187754	62/199 (31%)
		leucine-rich repeat	95..114	CDD:275381	8/19 (42%)
		leucine-rich repeat	121..146	CDD:275381	8/24 (33%)
		leucine-rich repeat	147..172	CDD:275381	10/27 (37%)
		leucine-rich repeat	173..198	CDD:275381	7/24 (29%)
		leucine-rich repeat	199..224	CDD:275381	6/24 (25%)
		AMN1	222..396	CDD:187754	54/174 (31%)
		leucine-rich repeat	225..250	CDD:275381	8/24 (33%)
		leucine-rich repeat	251..276	CDD:275381	8/24 (33%)
		leucine-rich repeat	277..302	CDD:275381	6/24 (25%)
		leucine-rich repeat	303..328	CDD:275381	5/24 (21%)
		leucine-rich repeat	329..357	CDD:275381	11/27 (41%)
		leucine-rich repeat	358..382	CDD:275381	8/24 (33%)
		leucine-rich repeat	383..408	CDD:275381	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910