Protein Alignment Ppa and FBXL17

DIOPT Version :9

• Sequence 1: NP_001261138.1
• Gene: Ppa / 37602
• FlyBaseID: FBgn0020257
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: XP_005272105.1
• Gene: FBXL17 / 64839
• HGNCID: 13615
• Length: 712
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 125/501 - (24%)
• Similarity: 214/501 - (42%)
• Gaps: 71/501 - (14%)

  Fly    25 CGGSGSNGAATSGGAAIGGAGAGGAPSWAMDE-LYQQTELPGLTRTGATTTHHHLLRFTPYALHH 88
            |||.|..|....||.. |.||.|.:|....|. ..|..|.|                  |..|..
Human   215 CGGGGCGGGGGGGGGG-GPAGGGASPPRPPDAGCCQAPEQP------------------PQPLCP 260

  Fly    89 RPPHHQLQTLPPALYLQHAAAAAAAAAAAAAHAQHHHH----HHHHLPHRPASPESPPPVEGTHI 149
            .|.....:..|    .:....|..|...|...||..|.    .....|..|......||.|...|
Human   261 PPSSPTSEGAP----TEAGGDAVRAGGTAPLSAQQQHECGDADCRESPENPCDCHREPPPETPDI 321

  Fly   150 SNLFPELLEQIFEHLPV--RDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKR 212
            :.|.|.:|.:||.:|.:  |.|. |:.||..|||.......||.::
Human   322 NQLPPSILLKIFSNLSLDERCLS-ASLVCKYWRDLCLDFQFWKQLD------------------- 366

  Fly   213 GIKKVQILSLRRSLKDLVLGVPA-----LTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCK 272
                   ||.|:.:.|.:|...|     :..:|:|.|.:::| |.....:...|.|.......||
Human   367 -------LSSRQQVTDELLEKIASRSQNIIEINISDCRSMSD-NGVCVLAFKCPGLLRYTAYRCK 423

  Fly   273 QITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGF 337
            |::|||:..:|.|...|:.:.:|....:|:.||..:....::||.::...|:.|||:|:..:
Human   424 QLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVI--- 485

  Fly   338 SRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQL 402
                |:|.|:|:.:.:|:.:.::|:::...|:....|:.:....| |||..|:.||.::..|..|
Human   486 ----AKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGC-SVTSKGVIHLTKLRNLSSL 545

  Fly   403 NLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQITDHGML 467
            :||....:.:..:..:.:....::||::.....|:|:.:..||:....|:.|.|..|:|||:.::
Human   546 DLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITDYALI 610

  Fly   468 KIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQL 513
            .|.:....:|.:::|.|..|||:|...:|:...:|:.:.|..|.::
Human   611 AIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKV 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	15/42 (36%)
		AMN1	<226..>334	CDD:187754	30/112 (27%)
		leucine-rich repeat	236..256	CDD:275381	5/19 (26%)
		leucine-rich repeat	263..288	CDD:275381	9/24 (38%)
		leucine-rich repeat	289..314	CDD:275381	5/24 (21%)
		leucine-rich repeat	315..347	CDD:275381	9/31 (29%)
		AMN1	347..524	CDD:187754	41/167 (25%)
		leucine-rich repeat	348..373	CDD:275381	4/24 (17%)
		leucine-rich repeat	374..398	CDD:275381	8/23 (35%)
		leucine-rich repeat	399..424	CDD:275381	4/24 (17%)
		leucine-rich repeat	425..450	CDD:275381	6/24 (25%)
		leucine-rich repeat	451..475	CDD:275381	8/23 (35%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
FBXL17	XP_005272105.1	F-box-like	321..368	CDD:289689	17/73 (23%)
		leucine-rich repeat	362..387	CDD:275381	8/50 (16%)
		leucine-rich repeat	388..413	CDD:275381	5/25 (20%)
		AMN1	411..573	CDD:187754	43/169 (25%)
		leucine-rich repeat	414..439	CDD:275381	9/24 (38%)
		leucine-rich repeat	440..465	CDD:275381	5/24 (21%)
		leucine-rich repeat	466..491	CDD:275381	9/31 (29%)
		leucine-rich repeat	492..517	CDD:275381	4/24 (17%)
		leucine-rich repeat	518..541	CDD:275381	8/23 (35%)
		leucine-rich repeat	542..567	CDD:275381	4/24 (17%)
		AMN1	547..>652	CDD:187754	26/104 (25%)
		leucine-rich repeat	568..593	CDD:275381	6/24 (25%)
		leucine-rich repeat	594..615	CDD:275381	8/20 (40%)
		leucine-rich repeat	619..641	CDD:275381	8/21 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810