DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and fbxl8

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001032499.2	Gene:	fbxl8 / 641481	ZFINID:	ZDB-GENE-051120-81	Length:	367	Species:	Danio rerio

Alignment Length:	265	Identity:	66/265 - (24%)
Similarity:	96/265 - (36%)	Gaps:	82/265 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 ELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQI 219
            |:|..||..||::|...|..||.||.:.....|.||..|.:.....|.|..::.|    :..|:.
Zfish     6 EILAHIFSFLPLQDKCNAFIVCKAWSNIMTHPSSWKDTEVRCESGTSVPDRYSDL----LPLVRN 66

  Fly   220 LSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSLGRIAQ 284
            |.||.||.|     ||                          |.||. |.:.:|......||
Zfish    67 LKLRISLTD-----PA--------------------------NRKTA-LWVLQQAVAGGDGR--- 96

  Fly   285 HLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLE 349
                ||.|.:  || :.||.|......|:               ||:..:      ...|: .|.
Zfish    97 ----LEGLSI--CC-VANTPLFYAGQDLQ---------------QGLVDI------LTNGS-SLT 132

  Fly   350 YLGLQDCQ-RLSDEALGHIAQGLTSLKSI---NLSFCVSVTDSGLKHLARMPKLEQLNLRSCDNI 410
            ...|:... .|||..:..:|....:|||:   |.|....||...|:|:          |:||.::
Zfish   133 IFDLKGVPFTLSDSFVRSVAMLCPALKSLYINNQSLVCGVTSETLRHV----------LKSCPSL 187

  Fly   411 SDIGM 415
            :.:|:
Zfish   188 NVLGV 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	13/34 (38%)
		AMN1	<226..>334	CDD:187754	22/107 (21%)
		leucine-rich repeat	236..256	CDD:275381	0/19 (0%)
		leucine-rich repeat	263..288	CDD:275381	6/24 (25%)
		leucine-rich repeat	289..314	CDD:275381	9/24 (38%)
		leucine-rich repeat	315..347	CDD:275381	3/31 (10%)
		AMN1	347..524	CDD:187754	19/73 (26%)
		leucine-rich repeat	348..373	CDD:275381	6/25 (24%)
		leucine-rich repeat	374..398	CDD:275381	9/26 (35%)
		leucine-rich repeat	399..424	CDD:275381	4/17 (24%)
		leucine-rich repeat	425..450	CDD:275381
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
fbxl8	NP_001032499.2	F-box-like	2..41	CDD:289689	13/34 (38%)
		leucine-rich repeat	131..157	CDD:275381	6/25 (24%)
		leucine-rich repeat	158..186	CDD:275381	12/37 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910