DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and fbxl7

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001073511.1	Gene:	fbxl7 / 569430	ZFINID:	ZDB-GENE-061215-122	Length:	489	Species:	Danio rerio

Alignment Length:	543	Identity:	132/543 - (24%)
Similarity:	231/543 - (42%)	Gaps:	88/543 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GSNGAATSGGAAIGGAGAGGAPSWAMDELYQQTELPGLTRTGATTTHHHLLRFTPYALHHRPPHH 93
            |:|....||....|.:......|.:.|:  ..|:.|   :..||:....|...|
Zfish     2 GANNGKQSGSEGKGSSSISSDLSSSTDQ--TSTKAP---KNAATSEDSDLSMRT----------- 50

  Fly    94 QLQTLPPALYLQHAAAAAAAAAAAAAHAQHH-------HHHHHHLPHRPASPESPPPVEGTHISN 151
             :.|..|||.|...:::|....::.:.:...       |.....|.|.......|...:|..:..
Zfish    51 -VSTPSPALILPPRSSSAVLNGSSTSSSTFGTETIAMVHMPPTSLTHPQRCLRQPRDQQGAPVDI 114

  Fly   152 LFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAK---LHLKRSSPSLFNCLVKRG 213
            |......|||.|||...|.|.|:||..|.:.|:...:|:.:...   ||:.|:
Zfish   115 LPDHAFLQIFTHLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGDVLHVDRA------------ 167

  Fly   214 IKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPN----LKTLDLSLCKQI 274
               :::|:.|                                ...|.||    ::|:.:|.|:::
Zfish   168 ---LRVLTRR--------------------------------LCQDTPNVCLTVETVMVSGCRRL 197

  Fly   275 TDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSR 339
            ||..|..:||....|..||:.||.|::|..:..:......|:||::..|..::...:........
Zfish   198 TDRGLYTVAQSCPELRRLEVAGCYNVSNEAVFEVVSRCPNLEHLDVSGCSKVTCISLTRDVSVKL 262

  Fly   340 ETAEG-NLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLA-RMPKLEQL 402
            ....| .:.:.:|.:.||..|.||.|..||...|.|..:.|..||.:||.||:.|. ..|.:.:|
Zfish   263 SPLHGQQISIRFLDMTDCFALEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRFLVIYCPGVREL 327

  Fly   403 NLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQ-ITDHGM 466
            ::..|..|||.|:..:.:....:..|.::.|.:|:|..:.::|:...|||.|:...|: :||||:
Zfish   328 SVSDCRFISDFGLREIAKLEGRLRYLSIAHCSRITDVGVRYVAKYCSRLRYLNARGCEGLTDHGI 392

  Fly   467 LKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDII------MKLP 525
            ..:||:..:|::|:||:|..::|.||:.||.:..|||.:.|..|..::.:|:.::      ::|.
Zfish   393 EHLAKSCLKLKSLDIGKCPLVSDAGLEQLALNSFNLKRLSLKSCESITGRGLQVVAANCFDLQLL 457

  Fly   526 KLQKLNLGLWLVRXCVHHDCNAC 548
            .:|..::.|..:| ...| |..|
Zfish   458 NVQDCDVSLEALRFVKRH-CKRC 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	14/40 (35%)
		AMN1	<226..>334	CDD:187754	22/111 (20%)
		leucine-rich repeat	236..256	CDD:275381	0/19 (0%)
		leucine-rich repeat	263..288	CDD:275381	8/24 (33%)
		leucine-rich repeat	289..314	CDD:275381	7/24 (29%)
		leucine-rich repeat	315..347	CDD:275381	5/32 (16%)
		AMN1	347..524	CDD:187754	58/184 (32%)
		leucine-rich repeat	348..373	CDD:275381	9/24 (38%)
		leucine-rich repeat	374..398	CDD:275381	9/24 (38%)
		leucine-rich repeat	399..424	CDD:275381	6/24 (25%)
		leucine-rich repeat	425..450	CDD:275381	5/24 (21%)
		leucine-rich repeat	451..475	CDD:275381	10/24 (42%)
		leucine-rich repeat	476..501	CDD:275381	10/24 (42%)
fbxl7	NP_001073511.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76		19/90 (21%)
		F-box-like	112..158	CDD:289689	15/45 (33%)
		leucine-rich repeat	127..151	CDD:275381	9/23 (39%)
		leucine-rich repeat	152..185	CDD:275381	9/79 (11%)
		LRR 1	168..193		6/56 (11%)
		AMN1	<183..364	CDD:187754	49/180 (27%)
		leucine-rich repeat	186..211	CDD:275381	8/24 (33%)
		LRR 2	194..219		9/24 (38%)
		leucine-rich repeat	212..233	CDD:275381	7/20 (35%)
		LRR 3	220..245		6/24 (25%)
		leucine-rich repeat	238..271	CDD:275381	5/32 (16%)
		LRR 4	251..279		2/27 (7%)
		leucine-rich repeat	272..297	CDD:275381	9/24 (38%)
		LRR 5	280..305		10/24 (42%)
		AMN1	295..463	CDD:187754	51/167 (31%)
		leucine-rich repeat	298..323	CDD:275381	9/24 (38%)
		LRR 6	306..331		9/24 (38%)
		leucine-rich repeat	324..349	CDD:275381	6/24 (25%)
		LRR 7	332..357		6/24 (25%)
		leucine-rich repeat	350..375	CDD:275381	5/24 (21%)
		LRR 8	358..383		8/24 (33%)
		leucine-rich repeat	376..401	CDD:275381	10/24 (42%)
		LRR 9	384..409		10/24 (42%)
		leucine-rich repeat	402..427	CDD:275381	10/24 (42%)
		LRR 10	410..435		10/24 (42%)
		leucine-rich repeat	428..451	CDD:275381	5/22 (23%)
		LRR 11	436..461		3/24 (13%)
		leucine-rich repeat	454..478	CDD:275381	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810