DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and rxfp2b

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001315011.1	Gene:	rxfp2b / 566888	ZFINID:	ZDB-GENE-110408-27	Length:	750	Species:	Danio rerio

Alignment Length:	465	Identity:	95/465 - (20%)
Similarity:	165/465 - (35%)	Gaps:	144/465 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LQHAAAAAA----------AAAAAAAHAQHHHHHHHHLPHRPASPESPPPVEGTHISNLFPELLE 158
            ||.||.|:|          :...|.|..:|.......|.|.|..          ::|...|::|.
Zfish     4 LQSAATASALELCLILFTTSITTAKAGQEHRPSEDCPLGHFPCG----------NVSICLPQVLH 58

  Fly   159 QIFEHLPVRDLGRAAQVCTAWRDAAYA--------KSVWKGVEAKLHLKRSSPSLFNCLVKRGIK 215
                             |...:|....        .|.|             ..||:...|||.
Zfish    59 -----------------CNNQKDCPNGADEDNCGDNSGW-------------ADLFDRTFKRGY- 92

  Fly   216 KVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLP----NLKTLDL--SLCKQI 274
                      |::|..........::..|.| .:::..||....:|    |:.:|.|  :..:.:
Zfish    93 ----------LQELATDCQVEQYPDVCRCIN-TEIHCVHASLRSIPQVSANVTSLSLKSNKIRTL 146

  Fly   275 TDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLA-GFS 338
            .|.:..:..:    |:.|.|...|  .||..:....||.||:.|:|      |...|..|: |..
Zfish   147 PDEAFIKYIK----LQRLFLQDNC--INTVSIQAFSGLYKLQKLSL------SQNSISLLSPGVF 199

  Fly   339 RETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHL------ARMP 397
            |:..    :|::|.|.| ..::..|....| ||:||      |.:|:.::.|:.|      |.||
Zfish   200 RDLR----KLKWLILDD-NPITTIAANTFA-GLSSL------FFLSMVNTSLEALPSARLCAHMP 252

  Fly   398 KLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQAL---------THIAQGLYRLRS 453
            .|..|:... ::|:.:|::.|.:            |:.::..:|         .:..|.|..:..
Zfish   253 FLSWLDFEG-NSITTLGLSTLLD------------CEHLTVLSLRANLIKSLPENTFQSLRMMGD 304

  Fly   454 LSLNQCQITDHGMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGI 518
            |.|:...|.:. .:.|.|.|..|::||:.|             ..|.::.........||.|.|:
Zfish   305 LDLSNNSIKEL-PVGIFKDLRSLQSLNLSQ-------------NPLDHIHPGQFNHLIQLQSLGL 355

  Fly   519 DIIMKLPKLQ 528
            :.: ::|.:|
Zfish   356 EGV-EIPNIQ 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	6/48 (13%)
		AMN1	<226..>334	CDD:187754	25/113 (22%)
		leucine-rich repeat	236..256	CDD:275381	3/19 (16%)
		leucine-rich repeat	263..288	CDD:275381	3/26 (12%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	8/32 (25%)
		AMN1	347..524	CDD:187754	41/191 (21%)
		leucine-rich repeat	348..373	CDD:275381	8/24 (33%)
		leucine-rich repeat	374..398	CDD:275381	7/29 (24%)
		leucine-rich repeat	399..424	CDD:275381	5/24 (21%)
		leucine-rich repeat	425..450	CDD:275381	4/33 (12%)
		leucine-rich repeat	451..475	CDD:275381	6/23 (26%)
		leucine-rich repeat	476..501	CDD:275381	5/24 (21%)
rxfp2b	NP_001315011.1	LDLa	39..74	CDD:238060	8/61 (13%)
		leucine-rich repeat	114..132	CDD:275380	3/17 (18%)
		LRR_RI	130..360	CDD:238064	62/281 (22%)
		leucine-rich repeat	133..156	CDD:275380	3/22 (14%)
		LRR_8	156..215	CDD:290566	21/75 (28%)
		leucine-rich repeat	157..180	CDD:275380	8/24 (33%)
		leucine-rich repeat	181..204	CDD:275380	8/32 (25%)
		LRR_8	203..288	CDD:290566	24/109 (22%)
		leucine-rich repeat	205..228	CDD:275380	8/24 (33%)
		leucine-rich repeat	229..253	CDD:275380	7/29 (24%)
		leucine-rich repeat	254..277	CDD:275380	6/35 (17%)
		LRR_8	277..336	CDD:290566	13/72 (18%)
		leucine-rich repeat	278..301	CDD:275380	3/22 (14%)
		leucine-rich repeat	302..325	CDD:275380	6/23 (26%)
		LRR_8	324..378	CDD:290566	11/55 (20%)
		leucine-rich repeat	326..349	CDD:275380	5/35 (14%)
		leucine-rich repeat	350..369	CDD:275380	5/16 (31%)
		7tm_4	419..>556	CDD:304433
		7tm_1	<487..686	CDD:278431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910