DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and FBXL19

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001093254.2	Gene:	FBXL19 / 54620	HGNCID:	25300	Length:	694	Species:	Homo sapiens

Alignment Length:	339	Identity:	85/339 - (25%)
Similarity:	129/339 - (38%)	Gaps:	94/339 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PHRPASPESPPPVEGTHISNLFPELLE--------------------QIFEHLPVRDLGRAAQVC 176
            |..||.|..||.:| .|:....|...|                    ::|:||..|:|....:||
Human   385 PLGPAPPPRPPQLE-RHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCICMRVC 448

  Fly   177 TAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKR----------GIKKVQILSLRRSLKDLVL 231
            ..|....|.|.:|..::.. ..|..:|.:.:.:|:|          |:.|.|::.|...|:
Human   449 RTWSRWCYDKRLWPRMDLS-RRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQ---- 508

  Fly   232 GVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSL----------------- 279
               .|..|.||||..::...||   |..||.|:.|||...:.:.|:.|
Human   509 ---GLQELVLSGCSWLSVSALG---SAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTES 567

  Fly   280 -GRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAE 343
             ||    |:.:..|.|.| ..:|:..|.|:.....:|..|:|..|.|:.|..: ||  .:..|:.
Human   568 RGR----LQGVAELRLAG-LELTDASLRLLLRHAPQLSALDLSHCAHVGDPSV-HL--LTAPTSP 624

  Fly   344 GNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRSCD 408
            ....|.:|.|..|.||:|.                   |:.:       ..|.|:|.:|:||||.
Human   625 LRETLVHLNLAGCHRLTDH-------------------CLPL-------FRRCPRLRRLDLRSCR 663

  Fly   409 NISDIGMAYLTEGG 422
            .:|....|.|...|
Human   664 QLSPEACARLAAAG 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	12/60 (20%)
		AMN1	<226..>334	CDD:187754	33/125 (26%)
		leucine-rich repeat	236..256	CDD:275381	8/19 (42%)
		leucine-rich repeat	263..288	CDD:275381	9/42 (21%)
		leucine-rich repeat	289..314	CDD:275381	6/24 (25%)
		leucine-rich repeat	315..347	CDD:275381	9/31 (29%)
		AMN1	347..524	CDD:187754	20/76 (26%)
		leucine-rich repeat	348..373	CDD:275381	7/24 (29%)
		leucine-rich repeat	374..398	CDD:275381	2/23 (9%)
		leucine-rich repeat	399..424	CDD:275381	10/24 (42%)
		leucine-rich repeat	425..450	CDD:275381
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
FBXL19	NP_001093254.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		zf-CXXC	<50..77	CDD:251032
		PHD_FXL19	87..148	CDD:277115
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..420		10/35 (29%)
		F-box-like	424..465	CDD:315592	11/40 (28%)
		leucine-rich repeat	461..485	CDD:275381	5/24 (21%)
		AMN1	466..665	CDD:332986	60/243 (25%)
		leucine-rich repeat	486..508	CDD:275381	4/21 (19%)
		LRR 1	492..517		8/31 (26%)
		leucine-rich repeat	510..533	CDD:275381	10/25 (40%)
		LRR 2	518..541		10/25 (40%)
		leucine-rich repeat	534..573	CDD:275381	9/42 (21%)
		leucine-rich repeat	574..598	CDD:275381	6/24 (25%)
		LRR 3	581..606		7/25 (28%)
		leucine-rich repeat	599..623	CDD:275381	8/26 (31%)
		LRR 4	607..636		9/31 (29%)
		leucine-rich repeat	629..653	CDD:275381	9/49 (18%)
		LRR 5	637..661		10/49 (20%)
		leucine-rich repeat	654..686	CDD:275381	10/24 (42%)
		LRR 6	662..694		5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910