DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Fbxl17

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_056609.1	Gene:	Fbxl17 / 50758	MGIID:	1354704	Length:	701	Species:	Mus musculus

Alignment Length:	529	Identity:	126/529 - (23%)
Similarity:	225/529 - (42%)	Gaps:	101/529 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CGGSGSNGAATSGGAAIGGAGAGGAPSWAMDE-LYQQTELPGLTRTGATTTHHHLLRFTPYALHH 88
            |||.|..|    ||.. |.||.|.:|....|. ..|..|.|
Mouse   218 CGGCGGGG----GGGG-GPAGGGASPPRPPDAGCCQAPEQP------------------------ 253

  Fly    89 RPPHHQLQTLPPALYLQHAAAAAA----AAAAAAAHAQHHHHHHHHLPHRPAS--------PESP 141
             ||........||.......|||.    |...|.:.||          .:|.|        ||:|
Mouse   254 -PPPLCPAPASPASECAPIVAAAGDTVRAGGTAPSSAQ----------QQPESGDADCQEPPENP 307

  Fly   142 ------PPVEGTHISNLFPELLEQIFEHLPVRDLGRAAQ-VCTAWRDAAYAKSVWKGVEAKLHLK 199
                  ||.|...|:.|.|.:|.:||.:|.:.:...:|. ||..|||.......||.::
Mouse   308 CDCHREPPPEIPDINQLPPSILLKIFSNLSLNERCLSASLVCKYWRDLCLDFQFWKQLD------ 366

  Fly   200 RSSPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPA-----LTSLNLSGCFNVADMNLGHAFSVD 259
                                ||.|:.:.|.:|...|     :..:|:|.|.:::|..: ...:..
Mouse   367 --------------------LSSRQQVTDELLEKIASRSQNIIEINISDCRSLSDSGV-CVLAFK 410

  Fly   260 LPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCW 324
            .|.|.......|||::|||:..:|.|...|:.:.:|....:|:.||..:....::||.::...|:
Mouse   411 CPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSRCRELKDIHFGQCY 475

  Fly   325 HISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSG 389
            .|||:|:..:       |:..|:|:.:.:|:.:.::|:::...|:....|:.:....| |||..|
Mouse   476 KISDEGMIVI-------AKSCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGC-SVTSKG 532

  Fly   390 LKHLARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSL 454
            :.||.::..|..|:||....:.:..:..:.:....::||::.....|:|:.:..||:....|:.|
Mouse   533 VIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKEL 597

  Fly   455 SLNQCQITDHGMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGID 519
            .|..|:|||:.::.|.:....:|.:::|.|..|||:|...:|:...:|:.:.|..|.:::...::
Mouse   598 YLVSCKITDYALIAIGRYSVTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNELTVE 662

  Fly   520 -IIMKLPKL 527
             ::.:.|.:
Mouse   663 QLVQQYPHI 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	13/41 (32%)
		AMN1	<226..>334	CDD:187754	29/112 (26%)
		leucine-rich repeat	236..256	CDD:275381	4/19 (21%)
		leucine-rich repeat	263..288	CDD:275381	9/24 (38%)
		leucine-rich repeat	289..314	CDD:275381	5/24 (21%)
		leucine-rich repeat	315..347	CDD:275381	8/31 (26%)
		AMN1	347..524	CDD:187754	41/177 (23%)
		leucine-rich repeat	348..373	CDD:275381	4/24 (17%)
		leucine-rich repeat	374..398	CDD:275381	8/23 (35%)
		leucine-rich repeat	399..424	CDD:275381	4/24 (17%)
		leucine-rich repeat	425..450	CDD:275381	6/24 (25%)
		leucine-rich repeat	451..475	CDD:275381	8/23 (35%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
Fbxl17	NP_056609.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..93
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..250		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..321		12/51 (24%)
		F-box-like	321..368	CDD:289689	15/72 (21%)
		leucine-rich repeat	362..387	CDD:275381	8/50 (16%)
		leucine-rich repeat	388..413	CDD:275381	4/25 (16%)
		AMN1	411..573	CDD:187754	42/169 (25%)
		leucine-rich repeat	414..439	CDD:275381	9/24 (38%)
		leucine-rich repeat	440..465	CDD:275381	5/24 (21%)
		leucine-rich repeat	466..491	CDD:275381	8/31 (26%)
		leucine-rich repeat	492..517	CDD:275381	4/24 (17%)
		leucine-rich repeat	545..567	CDD:275381	3/21 (14%)
		leucine-rich repeat	568..593	CDD:275381	6/24 (25%)
		leucine-rich repeat	594..618	CDD:275381	8/23 (35%)
		leucine-rich repeat	619..644	CDD:275381	8/24 (33%)
		leucine-rich repeat	645..670	CDD:275381	3/24 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810