DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and fbxl22

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001013297.1	Gene:	fbxl22 / 503591	ZFINID:	ZDB-GENE-050227-1	Length:	227	Species:	Danio rerio

Alignment Length:	277	Identity:	64/277 - (23%)
Similarity:	106/277 - (38%)	Gaps:	83/277 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 HISNLFPELLEQIFEHLPVRDLGRAAQV-CTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVK 211
            |:..|..|.|..:|.:|. :|..|:..: |...|.......:|    ..||.  .||    |
Zfish     2 HLIELDQECLLHLFSYLD-KDSRRSLSLTCVRLRQVFLDPQLW----TLLHF--WSP----C--- 52

  Fly   212 RGIKKVQILSLRRSLKDLVLGVPALTSLN-LSGCFNVADMNLGHAFSVDLPNLK-----TLDLSL 270
                     .|||.  :.|:|    :||. |:.|:        |:..|.:.|::     |....|
Zfish    53 ---------ELRRD--NFVVG----SSLRYLAVCW--------HSSRVKVCNIEHWMKTTFQKDL 94

  Fly   271 CKQ----ITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGI 331
            |.:    ::| .|..:.....||.:|.|.||.:|.:..::.:           |:||
Zfish    95 CSKHESFVSD-FLEHVCNMCPNLISLTLSGCGHIMDNNVIKV-----------LQSC-------- 139

  Fly   332 GHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLA-R 395
                          .:|..|.|::|.|::|..|....:...:|..:.:.||.:||.:||:.|. :
Zfish   140 --------------RRLRSLSLENCARITDSVLKAAVEHGHNLTEVRVDFCRNVTQAGLQELKNK 190

  Fly   396 MPKLEQLNLRSCDNISD 412
            .|::....|.|.|.|.|
Zfish   191 KPEVLLSALHSADMIPD 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	9/41 (22%)
		AMN1	<226..>334	CDD:187754	24/117 (21%)
		leucine-rich repeat	236..256	CDD:275381	5/20 (25%)
		leucine-rich repeat	263..288	CDD:275381	5/33 (15%)
		leucine-rich repeat	289..314	CDD:275381	6/24 (25%)
		leucine-rich repeat	315..347	CDD:275381	3/31 (10%)
		AMN1	347..524	CDD:187754	21/67 (31%)
		leucine-rich repeat	348..373	CDD:275381	7/24 (29%)
		leucine-rich repeat	374..398	CDD:275381	8/24 (33%)
		leucine-rich repeat	399..424	CDD:275381	5/14 (36%)
		leucine-rich repeat	425..450	CDD:275381
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
fbxl22	NP_001013297.1	F-box-like	9..48	CDD:289689	10/43 (23%)
		AMN1	<103..>191	CDD:187754	27/121 (22%)
		leucine-rich repeat	116..141	CDD:275381	9/57 (16%)
		leucine-rich repeat	142..167	CDD:275381	7/24 (29%)
		leucine-rich repeat	168..187	CDD:275381	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910