DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and Lrrc29

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_006255593.1	Gene:	Lrrc29 / 502201	RGDID:	1593150	Length:	673	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	119/566 - (21%)
Similarity:	199/566 - (35%)	Gaps:	199/566 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 PELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQ 218
            |::|..|...||:.|...|:.|..||..||........|...:.:..:|.|....|.:|||..:.
  Rat    59 PQMLTYILSFLPLSDQKEASLVSRAWYYAAQNALRETNVRYNIPVSSASLSAIKSLGRRGISCIS 123

  Fly   219 ILSL--------------------------------RRSLKDLVLGVPALTSLNLSGC------- 244
            :.:|                                ..|...|:||.|.|.:|:||||
  Rat   124 LTNLDGSPASHQVLQSVAYHLGPHLQSLCLGGGSPTEASFLALILGCPVLRTLDLSGCNSLFTSG 188

  Fly   245 ---------------------FNVA------DMNLGHAFS------------------------- 257
                                 .|:|      |::..|..|
  Rat   189 TLLAQPETAQCVRKALSGLRDLNLAGLRDLTDLSFNHLSSCFPSLERLSLAYCHLTFELGSTWGS 253

  Fly   258 ----------------------------------VDLP-------------NLKTLDLSLCKQIT 275
                                              ..||             .|:.|:|:.||.::
  Rat   254 TSPQASSPSQLSFHNLLQFIKERAGTLRALDLSGTGLPPEALQALGQVTGLKLEELNLNSCKDLS 318

  Fly   276 DTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGF--- 337
            ..::..:.:....|.:|:|.||..:|:..||.::.||..|:||:|:....::|.|...|...
  Rat   319 SEAVATLCRQQPGLTSLDLSGCSELTDRALLAVSRGLHHLRHLSLKKLQRLTDAGCIALGALHEL 383

  Fly   338 ------------SRETAE--GNLQ-----LEYLGLQDCQRLSDEALGHIAQGL-TSLKSINLSFC 382
                        .||.|:  |:::     |..|.|..|..|.|.::..:...| .|||.::||.|
  Rat   384 QSLDMAECCLVSGRELAQVLGSVRRAPPALTSLRLAYCSSLKDASVLSMIPALGPSLKVLDLSSC 448

  Fly   383 VSVTDSGLKHLAR-MPKLEQLNLRSCDNISDIGMAYLTE-------------------------- 420
            |::|:..::.:.. :..|..|.|..|..:.|.|:..|.|
  Rat   449 VALTNQTMQAICTYLIHLSVLRLAWCKELQDWGLLGLKEPSDEPVLNPQLHQEVENQAPDHQEPS 513

  Fly   421 ----GGS-----GINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQC-QITDHGMLKIAKALHE 475
                |.|     .:..||::.|.|::|.:|..:.| ..:||.|||:.. ..||.|::.:|:....
  Rat   514 SEPQGSSLLMLQALQELDLTACSKLTDASLAKVLQ-FPQLRQLSLSLLPAFTDMGLVAVARGCPS 577

  Fly   476 LENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDII 521
            ||.|.:..||.::|:|....|.....|:.::|..|:|::.:.:|.|
  Rat   578 LERLTLSHCSHLSDEGWVQAARLWPRLQHLNLSSCSQVTEQTLDTI 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	12/35 (34%)
		AMN1	<226..>334	CDD:187754	38/213 (18%)
		leucine-rich repeat	236..256	CDD:275381	10/53 (19%)
		leucine-rich repeat	263..288	CDD:275381	5/24 (21%)
		leucine-rich repeat	289..314	CDD:275381	10/24 (42%)
		leucine-rich repeat	315..347	CDD:275381	11/48 (23%)
		AMN1	347..524	CDD:187754	55/218 (25%)
		leucine-rich repeat	348..373	CDD:275381	7/25 (28%)
		leucine-rich repeat	374..398	CDD:275381	7/24 (29%)
		leucine-rich repeat	399..424	CDD:275381	10/59 (17%)
		leucine-rich repeat	425..450	CDD:275381	7/24 (29%)
		leucine-rich repeat	451..475	CDD:275381	9/24 (38%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
Lrrc29	XP_006255593.1	leucine-rich repeat	124..142	CDD:275381	1/17 (6%)
		LRR_RI	<170..410	CDD:238064	40/239 (17%)
		leucine-rich repeat	173..206	CDD:275381	6/32 (19%)
		leucine-rich repeat	207..232	CDD:275381	5/24 (21%)
		leucine-rich repeat	233..279	CDD:275381	0/45 (0%)
		leucine-rich repeat	280..300	CDD:275381	2/19 (11%)
		AMN1	292..480	CDD:187754	45/187 (24%)
		leucine-rich repeat	306..331	CDD:275381	5/24 (21%)
		leucine-rich repeat	332..357	CDD:275381	10/24 (42%)
		leucine-rich repeat	358..439	CDD:275381	18/80 (23%)
		leucine-rich repeat	383..408	CDD:275381	4/24 (17%)
		leucine-rich repeat	413..437	CDD:275381	6/23 (26%)
		leucine-rich repeat	440..465	CDD:275381	7/24 (29%)
		leucine-rich repeat	466..526	CDD:275381	10/59 (17%)
		leucine-rich repeat	527..577	CDD:275381	16/50 (32%)
		AMN1	<564..>638	CDD:187754	18/60 (30%)
		leucine-rich repeat	578..603	CDD:275381	8/24 (33%)
		leucine-rich repeat	604..629	CDD:275381	6/20 (30%)
		leucine-rich repeat	630..655	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810