DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Fbxl8

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001102598.1	Gene:	Fbxl8 / 498941	RGDID:	1566420	Length:	374	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	99/394 - (25%)
Similarity:	138/394 - (35%)	Gaps:	118/394 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 ISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSS---PSLFNCLV 210
            |..|..|:|..||..||:||...||:||.||..||...:||.........:..:   |.|..||
  Rat     5 IEKLPEEVLGLIFRDLPLRDRAVAARVCRAWAAAATNSAVWYDTSISCDCELENLLPPGLSACL- 68

  Fly   211 KRGIKKVQILSL---------RRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTL 266
                ..:..|||         ||:..:|      ||:|                 :...|.|:.|
  Rat    69 ----DHIHNLSLEYEPSKKPSRRTATEL------LTAL-----------------ASRAPRLRGL 106

  Fly   267 DLSLC---KQITDTS---LGRI------AQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHL- 318
            .|. |   |.:.|..   ||.:      |..||:|:...|.  ..:.:|.:|.:|.|..:|:.|
  Rat   107 RLE-CRGEKPLFDAGRDILGALHTVCGAAHQLRHLDLRHLP--YTVDDTLVLKVAGGCPELRSLF 168

  Fly   319 -----------------NLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGH 366
                             .|.:|.|:...|: |||..||..      ||.|           |..|
  Rat   169 LDNHALVNSVQPASVLRLLEACPHLRALGL-HLASMSRAA------LELL-----------AAPH 215

  Fly   367 IAQ-GLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDV 430
            .|. .|.:||      |....|      ||...|           .|...|.||....|: .:::
  Rat   216 RAPFTLLALK------CACPED------ARASPL-----------PDEAWATLTCYHPGL-KVEL 256

  Fly   431 SFCDKISDQALTHIAQGLYRLRSLSLNQCQITDHGMLKIAKALHELENLNIGQCSRITDKGLQTL 495
            .....:.|:|::.|.|....:..|.||....| .|.::.| |.|..|.|...:........|.|.
  Rat   257 ELEPVLPDEAVSRILQPAVPVAVLRLNLSGDT-VGPVRFA-ARHYAETLRALEVRASASTELHTA 319

  Fly   496 AEDL 499
            .|:|
  Rat   320 LEEL 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	19/40 (48%)
		AMN1	<226..>334	CDD:187754	28/137 (20%)
		leucine-rich repeat	236..256	CDD:275381	3/19 (16%)
		leucine-rich repeat	263..288	CDD:275381	10/36 (28%)
		leucine-rich repeat	289..314	CDD:275381	6/24 (25%)
		leucine-rich repeat	315..347	CDD:275381	11/49 (22%)
		AMN1	347..524	CDD:187754	37/154 (24%)
		leucine-rich repeat	348..373	CDD:275381	7/25 (28%)
		leucine-rich repeat	374..398	CDD:275381	6/23 (26%)
		leucine-rich repeat	399..424	CDD:275381	5/24 (21%)
		leucine-rich repeat	425..450	CDD:275381	4/24 (17%)
		leucine-rich repeat	451..475	CDD:275381	7/23 (30%)
		leucine-rich repeat	476..501	CDD:275381	6/24 (25%)
Fbxl8	NP_001102598.1	F-box-like	5..>34	CDD:403981	14/28 (50%)
		leucine-rich repeat	103..136	CDD:275381	9/33 (27%)
		leucine-rich repeat	137..163	CDD:275381	8/27 (30%)
		leucine-rich repeat	164..192	CDD:275381	4/27 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910