DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and kdm2a

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001011176.1	Gene:	kdm2a / 496596	XenbaseID:	XB-GENE-5900838	Length:	1146	Species:	Xenopus tropicalis

Alignment Length:	434	Identity:	98/434 - (22%)
Similarity:	145/434 - (33%)	Gaps:	109/434 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 QTELPGLTR-----------------TGATTTHHHLLRFT-PY--ALHHRPPHH--------QLQ 96
            ||::|..:|                 ||...:....||.. ||  ....|||..        :||
Frog   765 QTQVPLASREERAKRRQLAREKENHPTGCDQSEGDRLRLRGPYLTVTLQRPPKELSSTSIVPKLQ 829

  Fly    97 TLPPALYLQHAAAAAAAAAAAAAHAQHHHHHHHHLPHRPASPESPPPVEGTHISNLFPELLEQIF 161
            .:.|        .......||..|..................|:....:....:::..::...:|
Frog   830 AITP--------NPRQPIRAAPLHQDEEREEEEEEEEEEEETENVMLGQRKDSTSMQKDVWLSVF 886

  Fly   162 EHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKR----------GIKK 216
            .:|...:|....:||.||......|.:|..::.. ..|...|...:.::||          .:.|
Frog   887 HYLTHEELCICMRVCKAWYKWGCDKRLWSRIDVS-RCKSLVPQALSGIIKRQPIYLDLSWTNVSK 950

  Fly   217 VQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSLGR 281
            .|::.|...|       |.|..|.|:||...|...|.   |...|.|:||||.....|.||.:..
Frog   951 KQLIWLINRL-------PGLKDLILAGCTWSAVSALA---SCSCPLLRTLDLRWTVGIKDTQIRD 1005

  Fly   282 I------------AQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHL 334
            :            ...||.|..|.|.| .:|::..|.||......|..|:|..|..:|||.:..|
Frog  1006 LLTPASDKSGHDSRSKLRLLTDLRLSG-LDISDVTLRLIIRHCPLLSKLDLSHCPLLSDQSVNLL 1069

  Fly   335 AGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKL 399
            .                           |:|...:|  :|..|:|:.|..|||..|.:|.|...|
Frog  1070 T---------------------------AVGSSTRG--TLTHIHLAGCKGVTDESLLYLRRATNL 1105

  Fly   400 EQLNLRSCDNISDIGMAYLTEGG--SGINSLDVSFCDKISDQAL 441
            ..::|..|..:        |.|.  ..|:.|.||....:||..|
Frog  1106 SLIDLHGCKQV--------TRGACEEFISDLSVSTLYCLSDDKL 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	8/40 (20%)
		AMN1	<226..>334	CDD:187754	36/119 (30%)
		leucine-rich repeat	236..256	CDD:275381	7/19 (37%)
		leucine-rich repeat	263..288	CDD:275381	9/36 (25%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	8/31 (26%)
		AMN1	347..524	CDD:187754	25/97 (26%)
		leucine-rich repeat	348..373	CDD:275381	3/24 (13%)
		leucine-rich repeat	374..398	CDD:275381	10/23 (43%)
		leucine-rich repeat	399..424	CDD:275381	5/26 (19%)
		leucine-rich repeat	425..450	CDD:275381	7/17 (41%)
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
kdm2a	NP_001011176.1	JmjC	150..225	CDD:214721
		cupin_like	197..297	CDD:304367
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..467
		DUF1777	396..>440	CDD:285811
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	554..585
		zf-CXXC	<594..630	CDD:251032
		PHD_KDM2A	640..696	CDD:277113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	733..800		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	832..867		5/42 (12%)
		F-box-like	880..920	CDD:289689	9/39 (23%)
		leucine-rich repeat	889..911	CDD:275381	6/21 (29%)
		leucine-rich repeat	914..938	CDD:275381	5/24 (21%)
		leucine-rich repeat	939..962	CDD:275381	4/29 (14%)
		LRR 1	945..966		6/27 (22%)
		AMN1	<953..1118	CDD:187754	54/212 (25%)
		leucine-rich repeat	963..986	CDD:275381	8/25 (32%)
		LRR 2	968..994		12/28 (43%)
		leucine-rich repeat	987..1024	CDD:275381	9/36 (25%)
		leucine-rich repeat	1025..1049	CDD:275381	8/24 (33%)
		LRR 3	1032..1057		8/25 (32%)
		leucine-rich repeat	1050..1078	CDD:275381	10/54 (19%)
		LRR 4	1058..1087		11/57 (19%)
		leucine-rich repeat	1080..1102	CDD:275381	9/21 (43%)
		LRR 5	1088..1112		9/23 (39%)
		LRR 6	1113..1138		7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910