DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ppa and Fbxl7

DIOPT Version :9

Sequence 1:NP_001261138.1 Gene:Ppa / 37602 FlyBaseID:FBgn0020257 Length:562 Species:Drosophila melanogaster
Sequence 2:NP_795933.2 Gene:Fbxl7 / 448987 MGIID:3052506 Length:491 Species:Mus musculus


Alignment Length:555 Identity:137/555 - (24%)
Similarity:230/555 - (41%) Gaps:110/555 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 GSNGAATSGGAAIGGAGAGGAPSWAMDELYQQTELPGLTRTGATTTHHHLLRFTPYALHHRPPHH 93
            |:|.....|....|.:......|.:.|....:.:     |..||:....|...|           
Mouse     2 GANNGKQYGSEGKGSSSVSSDVSSSTDHTPTKAQ-----RNVATSEDSDLSMRT----------- 50

  Fly    94 QLQTLPPALY-------LQHAAAAAAAAAAAAAHAQHHHHHHHHLPHRPASPESPPPVEGTH--- 148
             |.|..|||.       .|:...::.::::.....             .|...||||...||   
Mouse    51 -LSTPSPALICPPTLPGFQNGRGSSTSSSSITGET-------------VAMVHSPPPTRLTHPLI 101

  Fly   149 ------------ISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRS 201
                        |..|....:.|||..||...|.|.|:||..|.:.|:...:|:.:       |.
Mouse   102 RLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI-------RL 159

  Fly   202 SPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPN---- 262
            :....|  |.|.:|   :|:.|                                ...|.||    
Mouse   160 TGETIN--VDRALK---VLTRR--------------------------------LCQDTPNVCLM 187

  Fly   263 LKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHIS 327
            |:|:.:|.|:::||..|..|||....|..||:.||.||:|..:..:......|:||::..|..::
Mouse   188 LETVIVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVT 252

  Fly   328 DQGIGHLAGFSRETAEG-NLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLK 391
            ...:...|........| .:.:.||.:.||..|.||.|..||...|.|..:.|..||.:||.||:
Mouse   253 CISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLR 317

  Fly   392 HLA-RMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLS 455
            :|. ....:::|::..|..:||.|:..:.:..|.:..|.::.|.:|:|..:.::|:...:||.|:
Mouse   318 YLVIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRITDVGIRYVAKYCSKLRYLN 382

  Fly   456 LNQCQ-ITDHGMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGID 519
            ...|: |||||:..:||...:|::|:||:|..::|.||::||.:..|||.:.|..|..::.:|:.
Mouse   383 ARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLESLALNCFNLKRLSLKSCESITGQGLQ 447

  Fly   520 II------MKLPKLQKLNLGLWLVRXCVHHDCNAC 548
            |:      :::..:|...:.:..:|....| |..|
Mouse   448 IVAANCFDLQMLNVQDCEVSVEALRFVKRH-CKRC 481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpaNP_001261138.1 F-box-like 149..190 CDD:289689 14/40 (35%)
AMN1 <226..>334 CDD:187754 25/111 (23%)
leucine-rich repeat 236..256 CDD:275381 0/19 (0%)
leucine-rich repeat 263..288 CDD:275381 10/24 (42%)
leucine-rich repeat 289..314 CDD:275381 8/24 (33%)
leucine-rich repeat 315..347 CDD:275381 6/32 (19%)
AMN1 347..524 CDD:187754 59/184 (32%)
leucine-rich repeat 348..373 CDD:275381 10/24 (42%)
leucine-rich repeat 374..398 CDD:275381 9/24 (38%)
leucine-rich repeat 399..424 CDD:275381 5/24 (21%)
leucine-rich repeat 425..450 CDD:275381 5/24 (21%)
leucine-rich repeat 451..475 CDD:275381 11/24 (46%)
leucine-rich repeat 476..501 CDD:275381 10/24 (42%)
Fbxl7NP_795933.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79 17/93 (18%)
F-box-like 114..160 CDD:289689 16/52 (31%)
leucine-rich repeat 129..151 CDD:275381 9/21 (43%)
leucine-rich repeat 154..187 CDD:275381 11/76 (14%)
AMN1 <185..366 CDD:187754 53/180 (29%)
LRR 1 185..210 9/24 (38%)
leucine-rich repeat 188..213 CDD:275381 10/24 (42%)
LRR 2 211..236 8/24 (33%)
leucine-rich repeat 214..234 CDD:275381 8/19 (42%)
LRR 3 237..262 5/24 (21%)
leucine-rich repeat 240..273 CDD:275381 6/32 (19%)
LRR 4 271..296 10/24 (42%)
leucine-rich repeat 274..299 CDD:275381 10/24 (42%)
AMN1 297..464 CDD:187754 50/166 (30%)
LRR 5 297..322 10/24 (42%)
leucine-rich repeat 300..325 CDD:275381 9/24 (38%)
LRR 6 323..348 5/24 (21%)
leucine-rich repeat 326..351 CDD:275381 5/24 (21%)
LRR 7 349..374 6/24 (25%)
leucine-rich repeat 352..377 CDD:275381 5/24 (21%)
LRR 8 375..400 10/24 (42%)
leucine-rich repeat 378..403 CDD:275381 11/24 (46%)
LRR 9 401..426 10/24 (42%)
leucine-rich repeat 404..429 CDD:275381 10/24 (42%)
LRR 10 427..452 7/24 (29%)
leucine-rich repeat 430..453 CDD:275381 6/22 (27%)
leucine-rich repeat 456..480 CDD:275381 4/24 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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