DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and FipoQ

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	109/471 - (23%)
Similarity:	178/471 - (37%)	Gaps:	117/471 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 PVEGTHISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFN 207
            |...|.|..|..::|..||.:|..|::.|.|::|..||..||...:||.|..:       |.:..
  Fly    28 PFADTTIEKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWKNVSLR-------PEVSG 85

  Fly   208 CLVKRGIKKVQILSLR--RSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNL--KTLDL 268
            ..|......:|::|:|  .:|:.:.|.:..:|...|            |..|...|||  ..||.
  Fly    86 LHVGSLEMLLQLISVRFGPTLRYIELPIELITHTVL------------HELSAKCPNLTHMLLDF 138

  Fly   269 SLCKQITDTS-------------------------LGRIAQHLRNLETLELGGC---C------- 298
            |...|:.|.|                         :.:|...:..||.|.|.|.   |
  Fly   139 STAMQLHDFSEMQAFPTKLRYMCVCLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEI 203

  Fly   299 -NITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDE 362
             .:.|...|..|  ...|:.:||.....|.|   .|:..||...    :|||.|.:..|.:::..
  Fly   204 YEVINVHKLKSA--TPNLRVINLYGINFIDD---SHIDAFSSNC----IQLECLAVNFCNKVTGS 259

  Fly   363 ALGHIAQ----------GLTSLKS---------------INLSFCVSVTDSGLKHLARMPKLEQL 402
            .|..:.|          ..|||||               ::::.....|:..:..|:|:|.|:.|
  Fly   260 TLKTLIQRSKRLTCLLMNGTSLKSEFVMQAEWDKCALQELDITATDLSTECLVDMLSRIPSLKFL 324

  Fly   403 NLRSCDNISDIGMAYLTEGGS--GINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQC------ 459
            :....:..:|..:....|.|:  .:.|||:...|.|||:.|....|    .:...|:.|
  Fly   325 SAGQINGFNDSVLKQWMESGTTRSLISLDLDSSDNISDEGLLKFIQ----RQGHQLSACCLSGMP 385

  Fly   460 QITDHGMLKIAKALHELENLNIGQCSRI-----TDKGLQTLAEDLTNLKTIDL------YGCTQL 513
            .|||...:.|...|...:.:.:|...::     .|:.:.|:|.:..||:.::|      ...:..
  Fly   386 HITDQLWMSILPLLGNCKIIVMGTAEKLGVNIHVDQLMDTIASNCGNLERLELRWDPDNLRFSDK 450

  Fly   514 SSKGIDII-MKLPKLQ 528
            |.|.|||: :|..||:
  Fly   451 SQKAIDILRVKCLKLR 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	14/40 (35%)
		AMN1	<226..>334	CDD:187754	30/145 (21%)
		leucine-rich repeat	236..256	CDD:275381	3/19 (16%)
		leucine-rich repeat	263..288	CDD:275381	8/51 (16%)
		leucine-rich repeat	289..314	CDD:275381	9/35 (26%)
		leucine-rich repeat	315..347	CDD:275381	8/31 (26%)
		AMN1	347..524	CDD:187754	49/221 (22%)
		leucine-rich repeat	348..373	CDD:275381	6/34 (18%)
		leucine-rich repeat	374..398	CDD:275381	6/38 (16%)
		leucine-rich repeat	399..424	CDD:275381	5/26 (19%)
		leucine-rich repeat	425..450	CDD:275381	9/24 (38%)
		leucine-rich repeat	451..475	CDD:275381	7/29 (24%)
		leucine-rich repeat	476..501	CDD:275381	4/29 (14%)
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	17/45 (38%)
		leucine-rich repeat	131..156	CDD:275381	7/24 (29%)
		leucine-rich repeat	157..175	CDD:275381	0/17 (0%)
		leucine-rich repeat	219..244	CDD:275381	8/31 (26%)
		leucine-rich repeat	245..270	CDD:275381	6/24 (25%)
		leucine-rich repeat	271..295	CDD:275381	5/23 (22%)
		leucine-rich repeat	296..320	CDD:275381	3/23 (13%)
		leucine-rich repeat	321..348	CDD:275381	5/26 (19%)
		leucine-rich repeat	349..375	CDD:275381	9/29 (31%)
		leucine-rich repeat	376..403	CDD:275381	7/26 (27%)
		leucine-rich repeat	405..432	CDD:275381	4/26 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457935
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740