DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and CG14891

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_650560.1	Gene:	CG14891 / 42013	FlyBaseID:	FBgn0038445	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	355	Identity:	90/355 - (25%)
Similarity:	147/355 - (41%)	Gaps:	72/355 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 HHHHLPHRPASPESPPPVEGTHISNL-FPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWK 190
            |.|.:...|..|..|...|...:..: .|.|.|..|..:.|              ..|:...::.
  Fly   181 HIHCVTGGPLHPNWPYLTEFVQLLGVSCPNLTELSFFKISV--------------SLAHMTHLFD 231

  Fly   191 GVEAKLHLKRSSPSLFNCLVK-------RGIKKVQILSLRR-------SLKDLVLGVPALTSLNL 241
            |....:::  ::.||..|.:|       :.:.|::.|.:|.       |||.|.:   :|..||:
  Fly   232 GANGLINI--TNISLRRCNLKDAHIYCLQMLSKLKSLDIRENFSIKGDSLKSLPI---SLEILNV 291

  Fly   242 SGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQIT----DTSL-GRIAQHLRNLETLELGGCCNIT 301
            |||.:::...|     :.|..|..|....|..|.    |..| ||:|.:...||.|||....|:.
  Fly   292 SGCVDLSPKCL-----IQLAALSHLRELRCPGIVKFAKDNELYGRLAHYCPMLEVLELTDFMNVI 351

  Fly   302 NTGLLLIAWGLKKLKHLNLRSC----WHISDQGIGHLAGFSRETAEGNLQLEYLGLQDC-QRLSD 361
            ..|      ||.:|..|.:.|.    :|:::..:..:|        .:..|.:|.:.|. ..:||
  Fly   352 QLG------GLSRLHTLVIHSSAQLDYHVNNVLLTSIA--------ESYSLRHLEILDSFGPMSD 402

  Fly   362 EALG-HIAQGLTSLKSI---NLSFCVSVTDSGLKHLARMPKLEQLNLRSCDNISDIGMAYLTEGG 422
            .:.. .|...|..|:::   |.:|    |...|..|.::..||.|:|....|:|:..:|.||:..
  Fly   403 TSFDLSIFSQLKELRTLILHNQNF----TTLHLMGLQKLSTLEFLDLSGSPNLSNEVVAKLTKSL 463

  Fly   423 SGINSLDVSFCDKISDQALTHIAQGLYRLR 452
            ||:..|.|.||..|:.| ||.|.:|..:|:
  Fly   464 SGLRRLKVDFCPLITRQ-LTKILEGNPKLQ 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	6/41 (15%)
		AMN1	<226..>334	CDD:187754	33/116 (28%)
		leucine-rich repeat	236..256	CDD:275381	7/19 (37%)
		leucine-rich repeat	263..288	CDD:275381	9/29 (31%)
		leucine-rich repeat	289..314	CDD:275381	9/24 (38%)
		leucine-rich repeat	315..347	CDD:275381	5/35 (14%)
		AMN1	347..524	CDD:187754	35/111 (32%)
		leucine-rich repeat	348..373	CDD:275381	7/26 (27%)
		leucine-rich repeat	374..398	CDD:275381	6/26 (23%)
		leucine-rich repeat	399..424	CDD:275381	9/24 (38%)
		leucine-rich repeat	425..450	CDD:275381	10/24 (42%)
		leucine-rich repeat	451..475	CDD:275381	1/2 (50%)
		leucine-rich repeat	476..501	CDD:275381
CG14891	NP_650560.1	RRM_6	25..91	CDD:290958
		AMN1	<199..352	CDD:187754	42/176 (24%)
		leucine-rich repeat	211..237	CDD:275381	6/39 (15%)
		leucine-rich repeat	239..262	CDD:275381	4/24 (17%)
		leucine-rich repeat	263..285	CDD:275381	6/24 (25%)
		leucine-rich repeat	286..338	CDD:275381	17/56 (30%)
		leucine-rich repeat	339..387	CDD:275381	14/61 (23%)
		leucine-rich repeat	388..415	CDD:275381	7/26 (27%)
		leucine-rich repeat	416..439	CDD:275381	6/26 (23%)
		leucine-rich repeat	440..465	CDD:275381	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457938
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840