DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and CG11044

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_611456.1	Gene:	CG11044 / 37281	FlyBaseID:	FBgn0034484	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	102/460 - (22%)
Similarity:	158/460 - (34%)	Gaps:	137/460 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 PEL-LEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKG--VEAKLHLKRSSPSLFN-------- 207
            |:| |||||.:|..::...|..||..|..|.|..:||..  |:.:...|..    ||
  Fly    55 PDLVLEQIFTYLTPKERYYAGLVCRQWYRAFYLPTVWNNFLVDDRTLTKPK----FNYYSGWQFC 115

  Fly   208 --------CLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFS--VDLPN 262
                    ||.:.|              ..|.|:               :....|:|:  .....
  Fly   116 LDHMRTQFCLSRIG--------------RYVRGI---------------EFRPWHSFNNIFQFMT 151

  Fly   263 LKTLDLSLCKQIT-DTSLGRIAQHLRNLETLELGGCCNITN----TGLLLIAWG---LKKLKHLN 319
            :.|.::...:::. ||....|...:|   ||.....||::.    .|:.|...|   |:.||.|.
  Fly   152 MLTWNIDKGREVNPDTQFIGIGSRIR---TLVYHFPCNMSQPNDPEGIKLFGTGGQLLRVLKELL 213

  Fly   320 LRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVS 384
            ||    ::|.....|..|..|..|.|            .|.||.   :....|.::.:||   |:
  Fly   214 LR----LTDLHTLKLVDFVLERYEAN------------HLLDEV---VCSCCTKMRVLNL---VN 256

  Fly   385 VT--DSGLKHLARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQAL--THIA 445
            ||  ...:.|:.....|:.|.: |..||.|..::.|                  :|..|  .|:.
  Fly   257 VTTMHCPIMHVGLFLNLQVLTI-SPQNIDDDVLSLL------------------ADTKLRHLHLL 302

  Fly   446 QGLYRLRSLSLNQCQITDHGMLKIAK---ALH-ELENLNIGQ--------------CSRITDKGL 492
            |..|....|:::.|.:.....:|...   .:| .||||..|:              |:..|....
  Fly   303 QNCYTPSHLTISACGVKAWRNVKKTNPRLRVHLRLENLTDGEVVLQPEAPVHSITYCAPQTRIRA 367

  Fly   493 QTLAEDLTNLK-TIDLYG---CTQLSS-----KGIDIIMKLPKLQKLNLGLWLVRXCVHHDCNAC 548
            :.|...:.:.| |:.:||   ..:.||     ..||.:|.|...|..|:...::|..|.......
  Fly   368 ELLVRMVDHYKSTLAVYGHELLPRFSSPKPFHSRIDSLMLLMCRQCFNVDTLIIREKVSTSTLLL 432

  Fly   549 AAKEA 553
            .||.|
  Fly   433 IAKTA 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	15/36 (42%)
		AMN1	<226..>334	CDD:187754	23/117 (20%)
		leucine-rich repeat	236..256	CDD:275381	1/19 (5%)
		leucine-rich repeat	263..288	CDD:275381	4/25 (16%)
		leucine-rich repeat	289..314	CDD:275381	8/31 (26%)
		leucine-rich repeat	315..347	CDD:275381	11/31 (35%)
		AMN1	347..524	CDD:187754	43/207 (21%)
		leucine-rich repeat	348..373	CDD:275381	3/24 (13%)
		leucine-rich repeat	374..398	CDD:275381	6/25 (24%)
		leucine-rich repeat	399..424	CDD:275381	7/24 (29%)
		leucine-rich repeat	425..450	CDD:275381	4/26 (15%)
		leucine-rich repeat	451..475	CDD:275381	4/27 (15%)
		leucine-rich repeat	476..501	CDD:275381	8/38 (21%)
CG11044	NP_611456.1	F-box-like	51..94	CDD:289689	16/38 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900