DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Fbxl2

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_038938600.1	Gene:	Fbxl2 / 363156	RGDID:	1562243	Length:	439	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	121/394 - (30%)
Similarity:	191/394 - (48%)	Gaps:	44/394 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 QIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNC------LVKRGIKK- 216
            :||..|.:..|.|.||:..||...|...|.|:.|:           |||.      .|...|.|
  Rat    38 RIFSFLDIVTLCRCAQISKAWNILALDGSNWQRVD-----------LFNFQTDVEGRVVENISKR 91

  Fly   217 ----VQILSLR-------RSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSL 270
                ::.||||       .|||........:..|||:||..:.|... ::.|.....||.|||:.
  Rat    92 CGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTC-YSLSRFCSKLKHLDLTS 155

  Fly   271 CKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLA 335
            |..:|::||..|::..||||.|.|..|..||..|:..:..|.:.||.|.||.|..:.|:.:.|:.
  Rat   156 CVSVTNSSLKGISEGCRNLEYLNLSWCDQITKEGIEALVRGCRGLKALLLRGCTQLEDEALKHIQ 220

  Fly   336 GFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLA-RMPKL 399
            ....|       |..|.||.|.|::|:.:..|.:|...|:::.||.|.::||:.|..|. ..|:|
  Rat   221 NHCHE-------LVSLNLQSCSRITDDGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRL 278

  Fly   400 EQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQ-ITD 463
            :.|....|.:::|.|...|......:..:|:..|..|:|..|..::....:|::|||:.|: |||
  Rat   279 QVLEAARCSHLTDAGFTLLARNCHDLEKMDLEECVLITDSTLIQLSIHCPKLQALSLSHCELITD 343

  Fly   464 HGMLKIAKAL--HE-LENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGID-IIMKL 524
            .|:|.::.:.  || |..|.:..|..:||..|:.| |:...|:.::||.|.|::..||. :..:|
  Rat   344 EGILHLSSSTCGHERLRVLELDNCLLVTDASLEHL-ENCRGLERLELYDCQQVTRAGIKRMRAQL 407

  Fly   525 PKLQ 528
            |:::
  Rat   408 PRVK 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	11/30 (37%)
		AMN1	<226..>334	CDD:187754	37/107 (35%)
		leucine-rich repeat	236..256	CDD:275381	6/19 (32%)
		leucine-rich repeat	263..288	CDD:275381	10/24 (42%)
		leucine-rich repeat	289..314	CDD:275381	9/24 (38%)
		leucine-rich repeat	315..347	CDD:275381	9/31 (29%)
		AMN1	347..524	CDD:187754	56/182 (31%)
		leucine-rich repeat	348..373	CDD:275381	9/24 (38%)
		leucine-rich repeat	374..398	CDD:275381	8/24 (33%)
		leucine-rich repeat	399..424	CDD:275381	6/24 (25%)
		leucine-rich repeat	425..450	CDD:275381	5/24 (21%)
		leucine-rich repeat	451..475	CDD:275381	10/26 (38%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
Fbxl2	XP_038938600.1	F-box-like	<38..72	CDD:403981	12/33 (36%)
		leucine-rich repeat	68..95	CDD:275381	8/37 (22%)
		AMN1	<92..239	CDD:187754	50/154 (32%)
		leucine-rich repeat	96..115	CDD:275381	7/18 (39%)
		leucine-rich repeat	122..147	CDD:275381	7/25 (28%)
		leucine-rich repeat	148..173	CDD:275381	10/24 (42%)
		leucine-rich repeat	174..199	CDD:275381	9/24 (38%)
		AMN1	184..383	CDD:187754	62/206 (30%)
		leucine-rich repeat	200..225	CDD:275381	8/24 (33%)
		leucine-rich repeat	226..251	CDD:275381	9/24 (38%)
		leucine-rich repeat	252..277	CDD:275381	8/24 (33%)
		leucine-rich repeat	278..303	CDD:275381	6/24 (25%)
		leucine-rich repeat	304..329	CDD:275381	5/24 (21%)
		leucine-rich repeat	330..352	CDD:275381	10/21 (48%)
		leucine-rich repeat	359..378	CDD:275381	6/18 (33%)
		leucine-rich repeat	384..409	CDD:275381	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910