DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and CG9003

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster

Alignment Length:	653	Identity:	143/653 - (21%)
Similarity:	268/653 - (41%)	Gaps:	169/653 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GSGSNGAATSGGAAIGGAGAGGA------PSWAMDELYQQTELPG----LTRTGA----TTTHHH 77
            |:||:.:...||::....||||:      ||.:       :.:.|    .:.:||    :.||..
  Fly    20 GTGSSSSNNGGGSSSNSGGAGGSIELLCPPSGS-------SSISGSASFSSNSGASGSSSQTHST 77

  Fly    78 LLRFTPYALHHRPPHHQLQTLPPALYL------------------QHAAAAAAA---------AA 115
            .:.......::...:|.     |:|.|                  ||:::::.:         ::
  Fly    78 AVSSATDRSNNNGNNHN-----PSLQLNGNGGSNTRQHSSGSNSRQHSSSSSNSNSSNISPPPSS 137

  Fly   116 AAAAHAQHHHHHH-------------------------HHLPHRPASPE-------------SPP 142
            ::::.:.:::::|                         :.||....:|:             |..
  Fly   138 SSSSRSNNNNNNHSSNIISGFCSTIWRSATFGSATPVINPLPAVSINPKIMESSSDSCSLSSSTT 202

  Fly   143 P-------------------------------VEGTHISNLFPELLEQIFEHLPVRDLGRAAQVC 176
            |                               ::...|..|..|:|.::|.:|.|..|.|.||||
  Fly   203 PDVGLADQQRNMAGSAQDQSEDQSQTFLGATELDDELIKQLPKEVLLRVFSYLDVVSLCRCAQVC 267

  Fly   177 TAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNL 241
            ..|...|...|.|:.:           :||:  .:|.|:...|.::.:..:..      |.||:|
  Fly   268 KYWNVLALDGSSWQKI-----------NLFD--FQRDIEGPVIENISQRCRGF------LKSLSL 313

  Fly   242 SGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLL 306
            .||.:|.|.:: ...:....|::.||||.||:|||.|...|:::...|..:.|..|.|||:..|.
  Fly   314 RGCQSVGDQSV-RTLANHCHNIEHLDLSDCKKITDISTQSISRYCSKLTAINLHSCSNITDNSLK 377

  Fly   307 LIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGL 371
            .::.|...|..:|:..|..||:.|:..|       |.|.::|.....:.|::::|.|:..:|:..
  Fly   378 YLSDGCPNLMEINVSWCHLISENGVEAL-------ARGCVKLRKFSSKGCKQINDNAIMCLAKYC 435

  Fly   372 TSLKSINLSFCVSVTDSGLKHL-ARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDK 435
            ..|..:||..|.::|||.::.| |...||::|.:..|.:::|:.:..|::....:|:|:||.|..
  Fly   436 PDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHNHLLNTLEVSGCRN 500

  Fly   436 ISDQALTHIAQGLYRLRSLSLNQC-QITDHGMLKIAKALHELENLNIGQCSRITDKGLQTL---- 495
            .:|.....:.:....|..:.|.:| ||||..:..:|.....||.|.:..|..|||.|::.|
  Fly   501 FTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGIRHLTTGS 565

  Fly   496 -AEDLTNLKTIDLYGCTQLSSKGIDIIMKLPKLQKLNLGLWLVRXCVHHDCNACAAKEAARGSYN 559
             |.::  |..::|..|..::.:.::.::....||::.|          .||. ...:.|.|...|
  Fly   566 CAAEI--LSVLELDNCPLITDRTLEHLVSCHNLQRIEL----------FDCQ-LITRTAIRKLKN 617

  Fly   560 SQP 562
            ..|
  Fly   618 HLP 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	16/40 (40%)
		AMN1	<226..>334	CDD:187754	34/107 (32%)
		leucine-rich repeat	236..256	CDD:275381	8/19 (42%)
		leucine-rich repeat	263..288	CDD:275381	11/24 (46%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	9/31 (29%)
		AMN1	347..524	CDD:187754	47/183 (26%)
		leucine-rich repeat	348..373	CDD:275381	5/24 (21%)
		leucine-rich repeat	374..398	CDD:275381	9/24 (38%)
		leucine-rich repeat	399..424	CDD:275381	5/24 (21%)
		leucine-rich repeat	425..450	CDD:275381	6/24 (25%)
		leucine-rich repeat	451..475	CDD:275381	8/24 (33%)
		leucine-rich repeat	476..501	CDD:275381	10/29 (34%)
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	17/55 (31%)
		leucine-rich repeat	280..307	CDD:275381	6/39 (15%)
		AMN1	<308..453	CDD:187754	48/152 (32%)
		leucine-rich repeat	308..327	CDD:275381	8/19 (42%)
		leucine-rich repeat	334..359	CDD:275381	11/24 (46%)
		leucine-rich repeat	360..385	CDD:275381	8/24 (33%)
		leucine-rich repeat	386..411	CDD:275381	9/31 (29%)
		AMN1	<409..586	CDD:187754	47/178 (26%)
		leucine-rich repeat	412..437	CDD:275381	5/24 (21%)
		leucine-rich repeat	438..463	CDD:275381	9/24 (38%)
		leucine-rich repeat	464..515	CDD:275381	11/50 (22%)
		leucine-rich repeat	516..541	CDD:275381	8/24 (33%)
		leucine-rich repeat	542..561	CDD:275381	8/18 (44%)
		leucine-rich repeat	571..595	CDD:275381	3/23 (13%)
		leucine-rich repeat	596..621	CDD:275381	9/36 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I1756
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46756
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.890