DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Fbxl7

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001102015.1	Gene:	Fbxl7 / 361907	RGDID:	1305813	Length:	491	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	125/479 - (26%)
Similarity:	212/479 - (44%)	Gaps:	87/479 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 PPAL-YLQHAAAAAAAAAAAAAHAQHHHHHHHHLPHRPASPESPPPVEGTH-------------- 148
            |||| ..|:...::.::::.....             .|...||||...||
  Rat    61 PPALPGFQNGRGSSTSSSSITGET-------------VAMVHSPPPTRLTHPLIRLASRPQKEQA 112

  Fly   149 -ISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKR 212
             |..|....:.|||..||...|.|.|:||..|.:.|:...:|:.:       |.:....|  |.|
  Rat   113 SIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI-------RLTGETIN--VDR 168

  Fly   213 GIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPN----LKTLDLSLCKQ 273
            .:|   :|:.|                                ...|.||    |:|:.:|.|::
  Rat   169 ALK---VLTRR--------------------------------LCQDTPNVCLMLETVIVSGCRR 198

  Fly   274 ITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFS 338
            :||..|..|||....|..||:.||.||:|..:..:......|:||::..|..::...:...|...
  Rat   199 LTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIK 263

  Fly   339 RETAEG-NLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLA-RMPKLEQ 401
            .....| .:.:.||.:.||..|.||.|..||...|.|..:.|..||.:||.||::|. ....:::
  Rat   264 LSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCTSIKE 328

  Fly   402 LNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQ-ITDHG 465
            |::..|..:||.|:..:.:..|.:..|.::.|.:|:|..:.::|:...:||.|:...|: |||||
  Rat   329 LSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRITDVGIRYVAKYCSKLRYLNARGCEGITDHG 393

  Fly   466 MLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDII------MKL 524
            :..:||...:|::|:||:|..::|.||::||.:..|||.:.|..|..::.:|:.|:      :::
  Rat   394 VEYLAKNCTKLKSLDIGKCPLVSDTGLESLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQM 458

  Fly   525 PKLQKLNLGLWLVRXCVHHDCNAC 548
            ..:|...:.:..:|....| |..|
  Rat   459 LNVQDCEVSVEALRFVKRH-CKRC 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	14/40 (35%)
		AMN1	<226..>334	CDD:187754	25/111 (23%)
		leucine-rich repeat	236..256	CDD:275381	0/19 (0%)
		leucine-rich repeat	263..288	CDD:275381	10/24 (42%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	6/32 (19%)
		AMN1	347..524	CDD:187754	59/184 (32%)
		leucine-rich repeat	348..373	CDD:275381	10/24 (42%)
		leucine-rich repeat	374..398	CDD:275381	9/24 (38%)
		leucine-rich repeat	399..424	CDD:275381	5/24 (21%)
		leucine-rich repeat	425..450	CDD:275381	5/24 (21%)
		leucine-rich repeat	451..475	CDD:275381	11/24 (46%)
		leucine-rich repeat	476..501	CDD:275381	10/24 (42%)
Fbxl7	NP_001102015.1	F-box-like	114..160	CDD:289689	16/52 (31%)
		leucine-rich repeat	129..151	CDD:275381	9/21 (43%)
		leucine-rich repeat	154..187	CDD:275381	11/76 (14%)
		AMN1	<185..366	CDD:187754	53/180 (29%)
		leucine-rich repeat	188..213	CDD:275381	10/24 (42%)
		leucine-rich repeat	214..234	CDD:275381	8/19 (42%)
		leucine-rich repeat	240..273	CDD:275381	6/32 (19%)
		leucine-rich repeat	274..299	CDD:275381	10/24 (42%)
		AMN1	297..464	CDD:187754	50/166 (30%)
		leucine-rich repeat	300..325	CDD:275381	9/24 (38%)
		leucine-rich repeat	326..351	CDD:275381	5/24 (21%)
		leucine-rich repeat	352..377	CDD:275381	5/24 (21%)
		leucine-rich repeat	378..403	CDD:275381	11/24 (46%)
		leucine-rich repeat	404..429	CDD:275381	10/24 (42%)
		leucine-rich repeat	430..453	CDD:275381	6/22 (27%)
		leucine-rich repeat	456..480	CDD:275381	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910