DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and CG8272

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster

Alignment Length:	650	Identity:	138/650 - (21%)
Similarity:	215/650 - (33%)	Gaps:	275/650 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 GTHISNLFP-ELLEQIFEHLPVRDLGRAAQVCTAWRDA------------AYAKSVWK------- 190
            |.|..:..| |::.:||.:|...||..|...|..|..|            .::|.|..
  Fly     7 GLHRYDDLPLEIVLKIFSYLGYSDLQAAGSTCQRWHAALDQAEFNQRTRVCFSKVVLSDQLSPGV 71

  Fly   191 ----------------------------------------------------GVEAKLH---LKR 200
                                                                ||...||   |||
  Fly    72 DLMRCERRFQHFLFEDVTLGQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPHLHSLSLKR 136

  Fly   201 ----------------SSPSLFNCLVKR--GIKKVQILSLRRSLKDLVL-----GVPALTSLNLS 242
                            |.|.| |.|...  |||::.:.. .:.|.|.:|     .:|:|.::|:|
  Fly   137 CLPLFMSGSFLDSYNNSCPDL-NDLASNLAGIKELTLCE-NQYLTDAILMRLTSFMPSLEAINMS 199

  Fly   243 GC--------------------------------FNVADMNL---------------GHA----- 255
            ||                                |.:..:||               |.|
  Fly   200 GCHIAFHNAIHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHTLIGQALLALC 264

  Fly   256 ------------------------FSVDLPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGG 296
                                    |....|.|..||||....:.|.:|..:.|....||.|::.|
  Fly   265 DLNLQLQRLYLAGCRQLNCTTILNFLATQPQLCALDLSATMCVNDENLAALVQTNPQLEHLKVNG 329

  Fly   297 CCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSD 361
            |.:|||.|.:.:| .||.||.|::.:|.:::..||  :.|.:.|......:|....||.|    :
  Fly   330 CLSITNAGAIHLA-KLKCLKSLDISNCDNLTSSGI--IEGIASEENPVIQELNVSYLQIC----E 387

  Fly   362 EALGHIAQGLTSLKSINLSFCVS-VTDSGLKH-LARMPKLEQLNLRSCDNISDIGMAYLT----- 419
            |.:..||..|..|:|::|:.||: .||..::. :.::..|.:|:|..|..::|..:..:.
  Fly   388 ECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVIGQLRWLRELSLEHCSGLTDAALTGINISKLE 452

  Fly   420 ----EGGS--------------------------------------------------------- 423
                :.||
  Fly   453 MSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSIKISLRSKAEDEIVRDARRKQAMLAAYEM 517

  Fly   424 -----------------GINSLDVSFCDKISDQALTHIAQGL--YRLRSLSLNQC-QITDHGMLK 468
                             |:.||::..|:||||.:|.:   ||  ..||.|.|:.| ||:..||..
  Fly   518 NLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVSLKY---GLKHIELRRLMLSNCQQISLLGMEA 579

  Fly   469 IAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGID-IIMKLPKLQKLNL 532
            :|.:...:|.|::..|..||||.:|.:...|..||.:.:.||:||:...:| ||.....||.|::
  Fly   580 MASSCPSIEELDLSDCYNITDKTIQVVTSKLPRLKALHISGCSQLTEHTLDAIITNCSCLQTLSI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	13/53 (25%)
		AMN1	<226..>334	CDD:187754	42/188 (22%)
		leucine-rich repeat	236..256	CDD:275381	10/95 (11%)
		leucine-rich repeat	263..288	CDD:275381	8/24 (33%)
		leucine-rich repeat	289..314	CDD:275381	11/24 (46%)
		leucine-rich repeat	315..347	CDD:275381	8/31 (26%)
		AMN1	347..524	CDD:187754	61/265 (23%)
		leucine-rich repeat	348..373	CDD:275381	8/24 (33%)
		leucine-rich repeat	374..398	CDD:275381	7/25 (28%)
		leucine-rich repeat	399..424	CDD:275381	7/107 (7%)
		leucine-rich repeat	425..450	CDD:275381	10/26 (38%)
		leucine-rich repeat	451..475	CDD:275381	10/24 (42%)
		leucine-rich repeat	476..501	CDD:275381	9/24 (38%)
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	49/177 (28%)
		leucine-rich repeat	270..295	CDD:275381	1/24 (4%)
		leucine-rich repeat	296..319	CDD:275381	8/22 (36%)
		leucine-rich repeat	322..346	CDD:275381	11/24 (46%)
		leucine-rich repeat	347..399	CDD:275381	16/57 (28%)
		leucine-rich repeat	400..426	CDD:275381	7/25 (28%)
		leucine-rich repeat	427..535	CDD:275381	7/107 (7%)
		AMN1	515..>642	CDD:187754	41/129 (32%)
		leucine-rich repeat	536..560	CDD:275381	10/26 (38%)
		leucine-rich repeat	561..586	CDD:275381	10/24 (42%)
		leucine-rich repeat	587..612	CDD:275381	9/24 (38%)
		leucine-rich repeat	613..638	CDD:275381	9/24 (38%)
		leucine-rich repeat	639..663	CDD:275381	3/5 (60%)
		F-box-like	12..>44	CDD:289689	10/31 (32%)
		leucine-rich repeat	129..166	CDD:275381	10/37 (27%)
		leucine-rich repeat	167..192	CDD:275381	5/25 (20%)
		leucine-rich repeat	193..244	CDD:275381	8/50 (16%)
		C2	<231..274	CDD:301316	5/42 (12%)
		leucine-rich repeat	246..269	CDD:275381	2/22 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840