DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and fbxl14a

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_958890.1	Gene:	fbxl14a / 333988	ZFINID:	ZDB-GENE-030131-5920	Length:	411	Species:	Danio rerio

Alignment Length:	388	Identity:	246/388 - (63%)
Similarity:	311/388 - (80%)	Gaps:	0/388 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 HISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKR 212
            |||:||||:|..||.:|.|:..||.||||||||||:|.||||:||||||||:|::||||..|..|
Zfish     4 HISSLFPEILAMIFNYLDVKGKGRVAQVCTAWRDASYHKSVWRGVEAKLHLRRANPSLFPSLQTR 68

  Fly   213 GIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDT 277
            ||||||||||||||..::.|:|.:.|||||||:|:.|..|||||..|:|:|:.|:|||||||||:
Zfish    69 GIKKVQILSLRRSLSYVIQGMPNIESLNLSGCYNLTDNGLGHAFVQDIPSLRILNLSLCKQITDS 133

  Fly   278 SLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETA 342
            |||||||:|:|||.|:||||.||||||||||||||..||.||||||.|:||.|||||||.:|..|
Zfish   134 SLGRIAQYLKNLELLDLGGCSNITNTGLLLIAWGLHNLKSLNLRSCRHVSDVGIGHLAGMTRSAA 198

  Fly   343 EGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRSC 407
            ||.|.||:|.|||||:|:|.:|.||::||..||.:|||||..::|:|:.||:.|.:|..||||||
Zfish   199 EGCLTLEHLTLQDCQKLTDLSLKHISKGLNKLKVLNLSFCGGISDAGMIHLSHMTQLWTLNLRSC 263

  Fly   408 DNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQITDHGMLKIAKA 472
            |||||.|:.:|:.|...:..||||||||:.||:|.:||||||:|:||||..|.|:|.|:.::.:.
Zfish   264 DNISDTGIMHLSMGALRLYGLDVSFCDKVGDQSLAYIAQGLYQLKSLSLCSCHISDDGINRMVRQ 328

  Fly   473 LHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDIIMKLPKLQKLNLGLW 535
            :|||:.||||||.|||||||:.:|:.||.|..|||||||:::.:|::.|.:||.|:.||||||
Zfish   329 MHELKTLNIGQCVRITDKGLELIADHLTQLTGIDLYGCTKITKRGLERITQLPCLKVLNLGLW 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	27/40 (68%)
		AMN1	<226..>334	CDD:187754	74/107 (69%)
		leucine-rich repeat	236..256	CDD:275381	12/19 (63%)
		leucine-rich repeat	263..288	CDD:275381	19/24 (79%)
		leucine-rich repeat	289..314	CDD:275381	21/24 (88%)
		leucine-rich repeat	315..347	CDD:275381	22/31 (71%)
		AMN1	347..524	CDD:187754	97/176 (55%)
		leucine-rich repeat	348..373	CDD:275381	15/24 (63%)
		leucine-rich repeat	374..398	CDD:275381	12/23 (52%)
		leucine-rich repeat	399..424	CDD:275381	15/24 (63%)
		leucine-rich repeat	425..450	CDD:275381	16/24 (67%)
		leucine-rich repeat	451..475	CDD:275381	9/23 (39%)
		leucine-rich repeat	476..501	CDD:275381	16/24 (67%)
fbxl14a	NP_958890.1	F-box-like	5..46	CDD:289689	27/40 (68%)
		AMN1	90..243	CDD:187754	103/152 (68%)
		leucine-rich repeat	92..118	CDD:275381	15/25 (60%)
		leucine-rich repeat	119..144	CDD:275381	19/24 (79%)
		leucine-rich repeat	145..170	CDD:275381	21/24 (88%)
		leucine-rich repeat	171..203	CDD:275381	22/31 (71%)
		leucine-rich repeat	204..229	CDD:275381	15/24 (63%)
		AMN1	230..397	CDD:187754	91/162 (56%)
		leucine-rich repeat	230..254	CDD:275381	12/23 (52%)
		leucine-rich repeat	255..280	CDD:275381	15/24 (63%)
		leucine-rich repeat	281..304	CDD:275381	14/22 (64%)
		leucine-rich repeat	307..331	CDD:275381	9/23 (39%)
		leucine-rich repeat	332..357	CDD:275381	16/24 (67%)
		leucine-rich repeat	358..377	CDD:275381	9/18 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577670
Domainoid	1	1.000	94	1.000	Domainoid score	I7428
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15271
Inparanoid	1	1.050	512	1.000	Inparanoid score	I1276
OMA	1	1.010	-	-		QHG59093
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	1	1.000	-	-		FOG0008216
OrthoInspector	1	1.000	-	-		otm25389
orthoMCL	1	0.900	-	-		OOG6_101394
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.270