DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Fbxl13

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_011248071.1	Gene:	Fbxl13 / 320118	MGIID:	2443416	Length:	889	Species:	Mus musculus

Alignment Length:	444	Identity:	105/444 - (23%)
Similarity:	183/444 - (41%)	Gaps:	93/444 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 RPASPE---SPPPVEGTHIS---NLFPE-LLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKG 191
            :|.|.|   |...||...|:   ::.|| .:.|||.:|..:|:...::|..:|.......|:|..
Mouse   218 KPISLEGSLSDIAVENRRIAFDISVLPEQAILQIFLYLTFKDMMACSRVNRSWMAMIQRGSLWNS 282

  Fly   192 VEAKLHLKRSSPSLFNCLVKRGIKKVQILSLR--------RSLKDLVLGVPALTSLNLSGCFNVA 248
            ::.......:...:...|.|   .::.:|.|.        ::|| .|.....|..||:|.|.:..
Mouse   283 IDFSTVKNIADKCVVTTLQK---WRLNVLRLNFRGCDFRTKTLK-AVSHCKNLQELNVSDCQSFT 343

  Fly   249 DMNLGHAFSVDLPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGL--LLIAWG 311
            |.::.| .|...|.:..|:|| ...||:.::..:.::..||:.|.|..|...|:.||  |.:..|
Mouse   344 DESMRH-ISEGCPGVLYLNLS-NTTITNRTMRLLPRYFHNLQNLSLAYCRKFTDKGLQYLNLGNG 406

  Fly   312 LKKLKHLNLRSCWHISDQGIGHLAGF--------------------------------------- 337
            ..||.:|:|..|..||.||..::|..
Mouse   407 CHKLIYLDLSGCTQISVQGFRNIASSCTGIVHLTINDMPTLTDNCVKVLVEKCPRISSVVLIGSP 471

  Fly   338 ----SRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPK 398
                |...|..:..|:.:..:..:|:||.....|.:....:..|.:..|..:|||.||.|:.:.:
Mouse   472 HISDSAFKALSSCDLKKIRFEGNKRISDACFKSIDRNYPGINHIYMVDCKGLTDSSLKSLSLLKQ 536

  Fly   399 LEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQIT- 462
            |..|||.:|..|.|||:.:..:|.:.|                        |||.|:|..|.:.
Mouse   537 LTVLNLTNCIRIGDIGLKHFFDGPASI------------------------RLRELNLTNCSLLG 577

  Fly   463 DHGMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSK 516
            |..::::::....|..||:..|..:||..::.:| .:.:|.::||.| |.:|::
Mouse   578 DSSVIRLSERCPNLHYLNLRNCEHLTDLAIEYIA-SMLSLISVDLSG-TLISNE 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	11/44 (25%)
		AMN1	<226..>334	CDD:187754	36/109 (33%)
		leucine-rich repeat	236..256	CDD:275381	7/19 (37%)
		leucine-rich repeat	263..288	CDD:275381	5/24 (21%)
		leucine-rich repeat	289..314	CDD:275381	9/26 (35%)
		leucine-rich repeat	315..347	CDD:275381	11/74 (15%)
		AMN1	347..524	CDD:187754	44/171 (26%)
		leucine-rich repeat	348..373	CDD:275381	5/24 (21%)
		leucine-rich repeat	374..398	CDD:275381	8/23 (35%)
		leucine-rich repeat	399..424	CDD:275381	10/24 (42%)
		leucine-rich repeat	425..450	CDD:275381	1/24 (4%)
		leucine-rich repeat	451..475	CDD:275381	6/24 (25%)
		leucine-rich repeat	476..501	CDD:275381	7/24 (29%)
Fbxl13	XP_011248071.1	F-box-like	240..284	CDD:372399	11/43 (26%)
		leucine-rich repeat	255..268	CDD:275381	3/12 (25%)
		leucine-rich repeat	280..306	CDD:275381	3/28 (11%)
		AMN1	306..475	CDD:187754	39/171 (23%)
		leucine-rich repeat	307..330	CDD:275381	5/23 (22%)
		leucine-rich repeat	331..356	CDD:275381	8/25 (32%)
		leucine-rich repeat	357..381	CDD:275381	5/24 (21%)
		leucine-rich repeat	382..409	CDD:275381	9/26 (35%)
		leucine-rich repeat	410..435	CDD:275381	9/24 (38%)
		leucine-rich repeat	436..461	CDD:275381	0/24 (0%)
		leucine-rich repeat	462..484	CDD:275381	2/21 (10%)
		AMN1	473..605	CDD:187754	38/155 (25%)
		leucine-rich repeat	486..511	CDD:275381	5/24 (21%)
		leucine-rich repeat	512..536	CDD:275381	8/23 (35%)
		leucine-rich repeat	537..564	CDD:275381	11/50 (22%)
		leucine-rich repeat	565..590	CDD:275381	6/24 (25%)
		leucine-rich repeat	591..610	CDD:275381	6/18 (33%)
		leucine-rich repeat	617..645	CDD:275381	5/14 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810