DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Fbxl12

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_006242701.1	Gene:	Fbxl12 / 313782	RGDID:	1305528	Length:	326	Species:	Rattus norvegicus

Alignment Length:	300	Identity:	79/300 - (26%)
Similarity:	122/300 - (40%)	Gaps:	89/300 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 ISNLF--PEL-LEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLV 210
            ::.||  |:| |.:||.:|||||..|.::||..|:.....:.:|:.|:..|:..|  |.:...|:
  Rat     1 MATLFDLPDLVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMR--PKVMWHLL 63

  Fly   211 KRGIKKVQILSLRRS----------------LKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVD 259
            :|.:.. ::.|||..                ::.|....|.|..|    |.:|||:::....|
  Rat    64 RRYMAS-RLHSLRMGGYLFSGSQAPQLSPALMRALGQKCPNLKRL----CLHVADLSMVPITS-- 121

  Fly   260 LPN-LKTLDLSLC--------KQITDTSLGRIA------------QHL------RNLETLELGGC 297
            ||: |:||:|..|        |:...|.|..:.            :||      |.|.:|.|||.
  Rat   122 LPSTLRTLELHSCEISMIWLQKEQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGT 186

  Fly   298 CNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDE 362
            ..:|.|||                      |..:..|:...|        ||.||   |...:|.
  Rat   187 YRVTETGL----------------------DSSLQELSYLQR--------LEVLG---CTLSADS 218

  Fly   363 ALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQL 402
            .|..|::.|..::.|.|: ...::..||..|..||.||.|
  Rat   219 TLLAISRHLRDVRKIRLT-VGGLSAQGLVFLEGMPVLESL 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	16/43 (37%)
		AMN1	<226..>334	CDD:187754	32/134 (24%)
		leucine-rich repeat	236..256	CDD:275381	6/19 (32%)
		leucine-rich repeat	263..288	CDD:275381	10/50 (20%)
		leucine-rich repeat	289..314	CDD:275381	9/24 (38%)
		leucine-rich repeat	315..347	CDD:275381	3/31 (10%)
		AMN1	347..524	CDD:187754	18/55 (33%)
		leucine-rich repeat	348..373	CDD:275381	9/24 (38%)
		leucine-rich repeat	374..398	CDD:275381	6/23 (26%)
		leucine-rich repeat	399..424	CDD:275381	2/3 (67%)
		leucine-rich repeat	425..450	CDD:275381
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
Fbxl12	XP_006242701.1	F-box-like	4..48	CDD:403981	17/43 (40%)
		leucine-rich repeat	104..125	CDD:275381	9/26 (35%)
		AMN1	121..>226	CDD:187754	34/139 (24%)
		leucine-rich repeat	126..152	CDD:275381	8/25 (32%)
		leucine-rich repeat	153..177	CDD:275381	2/23 (9%)
		leucine-rich repeat	178..203	CDD:275381	11/46 (24%)
		leucine-rich repeat	204..229	CDD:275381	10/35 (29%)
		leucine-rich repeat	230..253	CDD:275381	6/23 (26%)
		leucine-rich repeat	254..283	CDD:275381	2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810