DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Fbxl12

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001273458.1	Gene:	Fbxl12 / 30843	MGIID:	1354738	Length:	349	Species:	Mus musculus

Alignment Length:	272	Identity:	66/272 - (24%)
Similarity:	105/272 - (38%)	Gaps:	86/272 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 QVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQILSLRRS------------- 225
            :||..|:.....:.:|:.|:..|:..|  |.:...|::|.:.. ::.|||..
Mouse    52 RVCHRWKRLVDDRWLWRHVDLTLYTMR--PKVMWHLLRRYMAS-RLYSLRMGGYLFSGSQAPQLS 113

  Fly   226 ---LKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPN-LKTLDLSLC--------KQITDTS 278
               ::.|....|.|..|    |.:|||:::....|  ||: |:||:|..|        |:...|.
Mouse   114 PALMRALGQKCPNLKRL----CLHVADLSMVPITS--LPSTLRTLELHSCEISMIWLQKEQDPTV 172

  Fly   279 LGRIA------------QHL------RNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWH 325
            |..:.            :||      |.|.:|.|||...:|.|||   ...|::|.:|.
Mouse   173 LPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGL---DASLQELSYLQ------ 228

  Fly   326 ISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGL 390
                                 :||.||   |...:|..|..|::.|..::.|.|: ...::..||
Mouse   229 ---------------------RLEVLG---CTLSADSTLLAISRHLRDVRKIRLT-VGGLSAQGL 268

  Fly   391 KHLARMPKLEQL 402
            ..|..||.||.|
Mouse   269 VFLEGMPVLESL 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	3/15 (20%)
		AMN1	<226..>334	CDD:187754	34/134 (25%)
		leucine-rich repeat	236..256	CDD:275381	6/19 (32%)
		leucine-rich repeat	263..288	CDD:275381	10/50 (20%)
		leucine-rich repeat	289..314	CDD:275381	10/24 (42%)
		leucine-rich repeat	315..347	CDD:275381	2/31 (6%)
		AMN1	347..524	CDD:187754	19/56 (34%)
		leucine-rich repeat	348..373	CDD:275381	9/24 (38%)
		leucine-rich repeat	374..398	CDD:275381	6/23 (26%)
		leucine-rich repeat	399..424	CDD:275381	3/4 (75%)
		leucine-rich repeat	425..450	CDD:275381
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
Fbxl12	NP_001273458.1	F-box-like	<51..73	CDD:289689	5/20 (25%)
		leucine-rich repeat	127..148	CDD:275381	9/26 (35%)
		AMN1	144..>249	CDD:187754	34/139 (24%)
		leucine-rich repeat	149..175	CDD:275381	8/25 (32%)
		leucine-rich repeat	176..200	CDD:275381	2/23 (9%)
		leucine-rich repeat	201..226	CDD:275381	11/27 (41%)
		leucine-rich repeat	227..252	CDD:275381	10/54 (19%)
		leucine-rich repeat	253..276	CDD:275381	6/23 (26%)
		leucine-rich repeat	277..306	CDD:275381	3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810