DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppa and Fbxl6

DIOPT Version :9

Sequence 1:NP_001261138.1 Gene:Ppa / 37602 FlyBaseID:FBgn0020257 Length:562 Species:Drosophila melanogaster
Sequence 2:NP_038937.2 Gene:Fbxl6 / 30840 MGIID:1354705 Length:535 Species:Mus musculus


Alignment Length:482 Identity:130/482 - (26%)
Similarity:182/482 - (37%) Gaps:119/482 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 AAAHAQHHHHHHHHLPHRP---ASPESPPPVEGTHISNL-------FP-ELLEQIF-----EHLP 165
            |.||.:........|...|   |.|.:.|..|.:....|       .| |:|..||     .|.|
Mouse    61 ARAHRRARRRAPRSLARGPTAVAKPRTKPRPEPSLDQGLDSGWGDRIPLEVLVHIFGLLVAAHGP 125

  Fly   166 VRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVK---RGIKKV---------- 217
            :..|||||:||..|.:|....|:|       |....||||.....|   :|.||:          
Mouse   126 MPFLGRAARVCRHWHEATSHPSLW-------HTVTLSPSLVGRAGKGNLKGEKKLLACLEWLVPN 183

  Fly   218 ---QILSLR--------RSLKDLVLG-VPALTSLNLSGCFNVADMNL-------GHAFSVDL--- 260
               |:.||.        .|:.:||.. .|.||.|.||.|..|....|       ....|:||   
Mouse   184 RFSQLQSLTLIHWKSQVHSVLELVSKFCPRLTFLKLSDCHTVTAETLVMLARACCQLHSLDLHHS 248

  Fly   261 ---------------PNLKTLDLSLCKQITDTSLGRIAQH-LRNLETLELGGCCNITNTGLLLIA 309
                           ..::.|.|:...| |...||.:..: ...|:.|::....|..||.|.|..
Mouse   249 MVESTAVVSFLEEAGSRMRKLWLTYSSQ-TTAILGALLDNCCPQLQVLQVSTGMNCNNTPLQLPV 312

  Fly   310 WGLKK-------LKHLNL----RSCWHISDQGIGHLAGFSRETAEGNLQLEYLGL--QDCQRLSD 361
            ..|:|       |:.|||    :.|    .:|:....||.        .||.|.|  ..|..:|:
Mouse   313 EALQKGCPQLQVLRLLNLIWLPKPC----GRGVPQGPGFP--------SLEELCLAGSTCNFVSN 365

  Fly   362 EALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRSCDNISDIGMAYLTEGG---- 422
            |.||.:......|:.::|..|..||.|||.||. ..:||||.| ....||| |:....:|.    
Mouse   366 EVLGRLLHRSPKLRMLDLRGCARVTPSGLCHLP-CQELEQLYL-GLYGISD-GLTLAKDGSPLLT 427

  Fly   423 ----SGINSLDVS---FCDKISDQALTHIA---QGLY-RLRSLSLNQCQITDHGMLKIAKALHEL 476
                ..:..||.|   |.:|..:|||...:   .||: .|.||:|...::|...:..:......|
Mouse   428 RKWYHTLRELDFSGQGFSEKDLEQALAVFSGTPGGLHPALCSLNLRGTRVTPSTVSSVISGCPGL 492

  Fly   477 ENLNIGQCSRITDKGLQTLAEDLTNLK 503
            ..||:..| |...:||:.:...|..::
Mouse   493 LYLNLESC-RCLPRGLKRVYRGLEEVQ 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpaNP_001261138.1 F-box-like 149..190 CDD:289689 18/53 (34%)
AMN1 <226..>334 CDD:187754 35/145 (24%)
leucine-rich repeat 236..256 CDD:275381 8/26 (31%)
leucine-rich repeat 263..288 CDD:275381 6/25 (24%)
leucine-rich repeat 289..314 CDD:275381 8/24 (33%)
leucine-rich repeat 315..347 CDD:275381 8/35 (23%)
AMN1 347..524 CDD:187754 52/174 (30%)
leucine-rich repeat 348..373 CDD:275381 9/26 (35%)
leucine-rich repeat 374..398 CDD:275381 10/23 (43%)
leucine-rich repeat 399..424 CDD:275381 10/32 (31%)
leucine-rich repeat 425..450 CDD:275381 10/31 (32%)
leucine-rich repeat 451..475 CDD:275381 5/23 (22%)
leucine-rich repeat 476..501 CDD:275381 8/24 (33%)
Fbxl6NP_038937.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 61..99 9/37 (24%)
F-box-like 105..155 CDD:289689 19/56 (34%)
LRR 1 169..195 6/25 (24%)
AMN1 171..390 CDD:187754 55/231 (24%)
leucine-rich repeat 188..213 CDD:275381 5/24 (21%)
LRR 2 196..221 8/24 (33%)
leucine-rich repeat 214..239 CDD:275381 8/24 (33%)
LRR 3 222..247 6/24 (25%)
leucine-rich repeat 240..291 CDD:275381 9/51 (18%)
LRR 4 273..299 6/26 (23%)
leucine-rich repeat 292..321 CDD:275381 9/28 (32%)
LRR 5 304..329 7/24 (29%)
leucine-rich repeat 322..349 CDD:275381 8/38 (21%)
LRR 6 330..357 9/38 (24%)
AMN1 <349..500 CDD:187754 47/153 (31%)
leucine-rich repeat 350..377 CDD:275381 9/26 (35%)
LRR 7 360..385 7/24 (29%)
leucine-rich repeat 378..401 CDD:275381 10/23 (43%)
LRR 8 386..411 13/26 (50%)
LRR 9 415..441 4/25 (16%)
leucine-rich repeat 434..466 CDD:275381 10/31 (32%)
leucine-rich repeat 467..491 CDD:275381 5/23 (22%)
LRR 10 474..499 4/24 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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