DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Fbxo39

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001034107.1	Gene:	Fbxo39 / 303287	RGDID:	1311464	Length:	443	Species:	Rattus norvegicus

Alignment Length:	343	Identity:	72/343 - (20%)
Similarity:	134/343 - (39%)	Gaps:	98/343 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 LEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWK-------GVEAKLHLKRSSPSLFNCLVKRGI 214
            |.::|..|..||..|||.||..|....|:..:|:       |..:::|......:|:  .||:..
  Rat    24 LRRVFWWLGDRDRSRAALVCRKWNQIMYSADLWRYRTITFSGRPSRVHASEFESALW--YVKKFG 86

  Fly   215 KKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSL 279
            :.::.|.::                    ..|..:..|...|.|.:..|.:     |       |
  Rat    87 RYLEHLEIK--------------------FLNPYNAVLTKKFQVTMRGLLS-----C-------L 119

  Fly   280 GRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNL-RSCWHISDQG--IGHLAGFSRET 341
            |:....||:|                        .::||.| |..|..|.:|  |..|:.|.::.
  Rat   120 GKSNNRLRSL------------------------SIQHLELDRLVWRNSIRGSLIKSLSFFLKKM 160

  Fly   342 AEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLN--L 404
            .:   .|::|.|:.. ||:.|...||...|:.:::.|::..:::.|....||| :....|.|  :
  Rat   161 GK---HLDHLSLKGA-RLTVEQGCHILNSLSYMRNENVASELNIEDFFSHHLA-VYGSSQFNKAM 220

  Fly   405 RSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQ-GLYRLRSLSLNQCQITD-HGM- 466
            .:..|::.:.:.|                :.|||:.|..::: ....||:::: :|.:.| ||.
  Rat   221 ATFHNLTFLTLNY----------------NCISDELLETLSENNAGTLRTMNI-KCHVHDPHGQV 268

  Fly   467 ---LKIAKALHELENLNI 481
               :..||...:..||.:
  Rat   269 VWGMSWAKLARQASNLKV 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	12/32 (38%)
		AMN1	<226..>334	CDD:187754	19/110 (17%)
		leucine-rich repeat	236..256	CDD:275381	2/19 (11%)
		leucine-rich repeat	263..288	CDD:275381	5/24 (21%)
		leucine-rich repeat	289..314	CDD:275381	1/24 (4%)
		leucine-rich repeat	315..347	CDD:275381	10/34 (29%)
		AMN1	347..524	CDD:187754	32/143 (22%)
		leucine-rich repeat	348..373	CDD:275381	9/24 (38%)
		leucine-rich repeat	374..398	CDD:275381	5/23 (22%)
		leucine-rich repeat	399..424	CDD:275381	4/26 (15%)
		leucine-rich repeat	425..450	CDD:275381	4/25 (16%)
		leucine-rich repeat	451..475	CDD:275381	8/28 (29%)
		leucine-rich repeat	476..501	CDD:275381	2/6 (33%)
Fbxo39	NP_001034107.1	F-box-like	16..57	CDD:403981	12/32 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810