DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Amn1

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001008334.2	Gene:	Amn1 / 302032	RGDID:	1308119	Length:	258	Species:	Rattus norvegicus

Alignment Length:	287	Identity:	61/287 - (21%)
Similarity:	132/287 - (45%)	Gaps:	39/287 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 LPNLKTLD--LSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRS 322
            :|:.:.:.  |.||.:....::.|....::.|..       ||.:          :.:|.:::|.
  Rat     1 MPSSRVVSQLLELCLRCLIINISRYISDIKYLPP-------NIKD----------RLIKIMSMRG 48

  Fly   323 CWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFC----V 383
              .|:|..|..:.         :.:::.|.|:.| .:||.||.|:.: ...||::||..|    .
  Rat    49 --RITDSNINEVL---------HPEVQRLDLRSC-NISDVALQHLCK-CRKLKALNLKSCREHRN 100

  Fly   384 SVTDSGLKHLA-RMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQG 447
            |:|..|:|.:| ....|.:::|:.|.:::|.|:..|......:..:|:..|..|:|::|..:.:.
  Rat   101 SITSEGIKAVASSCSDLHEISLKGCCSVTDEGVLALALNCQLLKIIDLGGCLSITDESLHALGKN 165

  Fly   448 LYRLRSLSLNQCQITDHGMLKIAK--ALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGC 510
            ...|:.:..:..|::|:|::.:..  ...:||.:|:|.|..:|||.::........:..:..:||
  Rat   166 CPFLQCVDFSTTQVSDNGVVALVSGPCAKQLEEINMGYCINLTDKAVEAALTACPQICILLFHGC 230

  Fly   511 TQLSSKGIDIIMKLPKLQKLNLGLWLV 537
            ..::....:::.:|...:||....|.|
  Rat   231 PLITDHSREVLEQLIGSRKLKQVTWSV 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689
		AMN1	<226..>334	CDD:187754	13/75 (17%)
		leucine-rich repeat	236..256	CDD:275381
		leucine-rich repeat	263..288	CDD:275381	4/26 (15%)
		leucine-rich repeat	289..314	CDD:275381	3/24 (13%)
		leucine-rich repeat	315..347	CDD:275381	5/31 (16%)
		AMN1	347..524	CDD:187754	43/183 (23%)
		leucine-rich repeat	348..373	CDD:275381	8/24 (33%)
		leucine-rich repeat	374..398	CDD:275381	10/28 (36%)
		leucine-rich repeat	399..424	CDD:275381	6/24 (25%)
		leucine-rich repeat	425..450	CDD:275381	5/24 (21%)
		leucine-rich repeat	451..475	CDD:275381	4/25 (16%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
Amn1	NP_001008334.2	leucine-rich repeat	10..35	CDD:275381	5/31 (16%)
		leucine-rich repeat	36..58	CDD:275381	6/33 (18%)
		AMN1	37..257	CDD:187754	52/242 (21%)
		leucine-rich repeat	63..86	CDD:275381	8/24 (33%)
		leucine-rich repeat	87..116	CDD:275381	10/28 (36%)
		leucine-rich repeat	117..142	CDD:275381	6/24 (25%)
		leucine-rich repeat	143..168	CDD:275381	5/24 (21%)
		leucine-rich repeat	169..195	CDD:275381	4/25 (16%)
		leucine-rich repeat	196..221	CDD:275381	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900